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European Journal of Trauma and Emergency Surgery
Published in: European Journal of Trauma and Emergency Surgery 4/2018

01-08-2018 | Original Article

Interleukin-17 as a predictor of sepsis in polytrauma patients: a prospective cohort study

Authors: M. Ahmed Ali, E. S. Mikhael, A. Abdelkader, L. Mansour, R. El Essawy, R. El Sayed, A. Eladawy, A. Mukhtar

Published in: European Journal of Trauma and Emergency Surgery | Issue 4/2018

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Abstract

Sepsis is one of the most serious complications after major trauma, and may be associated with increased mortality. We sought to determine whether there is an association between serum levels of interleukin-17 (IL-17) at the time of admission to the intensive care unit (ICU) and the development of sepsis. We evaluated 100 adult patients with major trauma admitted to the surgical ICU over a 6-month period. Serum levels of IL-17, IL-6, and TNF-α were determined by enzyme-linked immunosorbent assays (ELISA). The IL-17 rs1974226 genotype was determined by real-time PCR. In both non-adjusted and adjusted analyses, IL-17 was the only biomarker significantly associated with sepsis [median serum IL-17 of 72 pg/mL in sepsis versus 37 pg/mL in those without sepsis, P = 0.0001; adjusted odds ratio (OR) 3.2, P = 0.02]. No significant association was found among IL-17 rs1974226 genotypes and related serum cytokine levels. These data suggest that elevated serum IL-17 may increase the susceptibility for septic complications in polytrauma patients and so could be a useful biomarker for trauma patient management.
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Metadata
Title
Interleukin-17 as a predictor of sepsis in polytrauma patients: a prospective cohort study
Authors
M. Ahmed Ali
E. S. Mikhael
A. Abdelkader
L. Mansour
R. El Essawy
R. El Sayed
A. Eladawy
A. Mukhtar
Publication date
01-08-2018
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Trauma and Emergency Surgery / Issue 4/2018
Print ISSN: 1863-9933
Electronic ISSN: 1863-9941
DOI
https://doi.org/10.1007/s00068-017-0841-3

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