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European Journal of Trauma and Emergency Surgery
Published in: European Journal of Trauma and Emergency Surgery 5/2017

Open Access 01-10-2017 | Original Article

Extracorporeal membrane oxygenation improves coagulopathy in an experimental traumatic hemorrhagic model

Authors: M. Larsson, P. Forsman, P. Hedenqvist, A. Östlund, J. Hultman, A. Wikman, L. Riddez, B. Frenckner, M. Bottai, C.-M. Wahlgren

Published in: European Journal of Trauma and Emergency Surgery | Issue 5/2017

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Abstract

Purpose

Hemorrhage is the most common cause of preventable death after trauma. Coagulopathy plays a central role in uncontrolled bleeding and is caused by multiple factors. Extracorporeal Membrane Oxygenation (ECMO) is an established treatment for patients with respiratory failure and has in recent years also been used in severely injured trauma patients with cardiopulmonary failure and coexisting bleeding shock. The aim of this study was to evaluate the effect of ECMO on hypothermia, acidosis, and coagulopathy in a traumatic hemorrhagic rabbit model.

Methods

After anesthesia and tracheostomy, ten New Zealand White rabbits sustained laparotomy, bilateral femur fractures and were hemorrhaged 45% of their estimated blood volume. After 90 min of hemorrhagic shock they were resuscitated with a standard transfusion protocol together with venoarterial ECMO (n = 5) or with a standard transfusion protocol only (n = 5) for 60 min. No systemic heparin was administered.

Results

ECMO during 60 min of resuscitation significantly increased heart rate (p = 0.01), mean arterial pressure (p = 0.01), body temperature (p = 0.01) and improved the metabolic acidosis, pH (p = 0.01), and lactate (p = 0.01). ECMO also improved the coagulation capacity measured in vitro by Rotational Thromboelastometry with a significant decrease in clot formation time (p < 0.01). This finding was confirmed in vivo with a significant reduction in the animals’ ear bleeding time (p < 0.01) and cuticle bleeding time (p < 0.01); 5/5 animals survived in the ECMO group and 3/5 animals survived in the control group.

Conclusions

Heparin-free ECMO stabilizes circulation, improves coagulation, and may impact short-time survival, during the first 60 min, in an experimental traumatic model with severe hemorrhagic shock.
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Metadata
Title
Extracorporeal membrane oxygenation improves coagulopathy in an experimental traumatic hemorrhagic model
Authors
M. Larsson
P. Forsman
P. Hedenqvist
A. Östlund
J. Hultman
A. Wikman
L. Riddez
B. Frenckner
M. Bottai
C.-M. Wahlgren
Publication date
01-10-2017
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Trauma and Emergency Surgery / Issue 5/2017
Print ISSN: 1863-9933
Electronic ISSN: 1863-9941
DOI
https://doi.org/10.1007/s00068-016-0730-1

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