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Open Access 21-02-2024 | Literatur kommentiert

Mepitel-Film zur Prävention der Radiodermatitis bei Brustbestrahlung

Authors: Dr. Cas Stefaan Dejonckheere, Ulrike Höller, Leonard Christopher Schmeel

Published in: Strahlentherapie und Onkologie | Issue 4/2024

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Nach initial widersprüchlichen Ergebnissen über die Wirksamkeit von Mepitel-Film zur Radiodermatitisprophylaxe im Rahmen der Brustbestrahlung in zwei randomisierten Phase-II-Studien [1, 2] führten Behroozian et al. eine randomisierte Phase-III-Studie durch, um die präventive Effektivität abschließend zu beurteilen [3]. …

Herst PM, Bennett NC, Sutherland AE, Peszynski RI, Paterson DB, Jasperse ML (2014) Prophylactic use of mepitel film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patients. Radiother Oncol 110:137–143. https://doi.org/10.1016/j.radonc.2014.01.005CrossRefPubMed

Møller PK, Olling K, Berg M, Habæk I, Haislund B, Iversen A‑M et al (2018) Breast cancer patients report reduced sensitivity and pain using a barrier film during radiotherapy—A Danish intra-patient randomized multicentre study. Tech Innov Patient Support Radiat Oncol 7:20–25. https://doi.org/10.1016/j.tipsro.2018.05.004CrossRefPubMedPubMedCentral

Behroozian T, Milton L, Karam I, Zhang L, Ding K, Lou J et al (2022) Mepitel film for the prevention of acute radiation dermatitis in breast cancer: a randomized multicenter open-label phase III trial. J Clin Oncol 22:1873. https://doi.org/10.1200/JCO.22.01873CrossRef

Schmeel LC, Koch D, Stumpf S, Leitzen C, Simon B, Schüller H et al (2018) Prophylactically applied hydrofilm polyurethane film dressings reduce radiation dermatitis in adjuvant radiation therapy of breast cancer patients. Acta Oncol 57:908–915. https://doi.org/10.1080/0284186X.2018.1441542CrossRefPubMed

Schmeel LC, Koch D, Schmeel FC, Bücheler B, Leitzen C, Mahlmann B et al (2019) Hydrofilm polyurethane films reduce radiation dermatitis severity in hypofractionated whole-breast irradiation: an objective, intrapatient randomized dual-center assessment. Polymers. https://doi.org/10.3390/polym11122112CrossRefPubMedPubMedCentral

Böhner AMC, Koch D, Schmeel FC, Röhner F, Schoroth F, Sarria GR et al (2020) Objective evaluation of risk factors for radiation dermatitis in whole-breast irradiation using the spectrophotometric L*a*b* colour-space. Cancers. https://doi.org/10.3390/cancers12092444CrossRefPubMedPubMedCentral

Behroozian T, Milton L, Zhang L, Lou J, Karam I, Lam E et al (2021) How do patient-reported outcomes compare with clinician assessments? A prospective study of radiation dermatitis in breast cancer. Radiother Oncol 159:98–105. https://doi.org/10.1016/j.radonc.2021.03.020CrossRefPubMed

Rades D, Narvaez CA, Splettstößer L, Dömer C, Setter C, Idel C et al (2019) A randomized trial (RAREST-01) comparing Mepitel® film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN). Radiother Oncol 139:79–82. https://doi.org/10.1016/j.radonc.2019.07.023CrossRefPubMed

Title: Mepitel-Film zur Prävention der Radiodermatitis bei Brustbestrahlung
Authors: Dr. Cas Stefaan Dejonckheere
Ulrike Höller
Leonard Christopher Schmeel
Publication date: 21-02-2024
Publisher: Springer Berlin Heidelberg
Published in: Strahlentherapie und Onkologie / Issue 4/2024
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-024-02217-7

At a glance: The STEP trials

Springer Medicine

Mepitel-Film zur Prävention der Radiodermatitis bei Brustbestrahlung

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At a glance: The STEP trials

Springer Medicine

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