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Strahlentherapie und Onkologie
Published in: Strahlentherapie und Onkologie 4/2024

05-02-2024 | Literatur kommentiert

Verbesserte Schluckfunktion nach definitiver Radiochemotherapie bei Oro- und Hypopharynxkarzinomen durch Schonung der Musculi constrictores pharyngis

Author: Alexander M. Ziebolz

Published in: Strahlentherapie und Onkologie | Issue 4/2024

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Auszug

Bei fortgeschrittenen Oropharynx- und Hypopharynxkarzinomen ist die definitive simultane Radiochemotherapie mit Cisplatin eine mindestens gleichwertige organerhaltende Alternative zur operativen Versorgung [1, 2]. Eine der häufigsten Nebenwirkungen ist eine Dysphagie, die zu Unterernährung und sogar aspirationsbedingten Todesfällen (bis zu 20 % der nichttumorassoziierten Todesfälle) führen kann [3]. In der Dysphagia/Aspiration-at-risk-structures(DARS)-Studie sollte geprüft werden, ob eine gezielte Schonung der Mm. constrictores pharyngis zu verbesserter langfristiger Schluckfunktion bei gleichbleibenden onkologischen Endpunkten führen wird [4]. …
Literature
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Kramer S, Gelber RD, Snow JB et al (1987) Combined radiation therapy and surgery in the management of advanced head and neck cancer: final report of study 73-03 of the Radiation Therapy Oncology Group. Head Neck Surg 10:19–30CrossRefPubMed
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Calais G, Alfonsi M, Bardet E, Sire C, Germain T, Bergerot P, Rhein B, Tortochaux J, Oudinot P, Bertrand P (1999) Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma. J Natl Cancer Inst 91:2081–2086CrossRefPubMed
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Szczesniak MM, Maclean J, Zhang T et al (2014) Persistent dysphagia after head and neck radiotherapy: a common and under-reported complication with significant effect on non-cancer-related mortality. Clin Oncol (R Coll Radiol) 26:697–703CrossRefPubMed
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Nutting C, Finneran L, Roe J et al (2023) Dysphagia-optimised intensity-modulated radiotherapy versus standard intensity-modulated radiotherapy in patients with head and neck cancer (DARS): a phase 3, multicentre, randomised, controlled trial. Lancet Oncol 24:868–880CrossRefPubMed
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Hutcheson KA, Barrow MP, Lisec A et al (2016) What is a clinically relevant difference in MDADI scores between groups of head and neck cancer patients? Laryngoscope 126:1108–1113CrossRefPubMed
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Carlsson S, Rydén A, Rudberg I et al (2012) Validation of the Swedish M. D. Anderson Dysphagia Inventory (MDADI) in patients with head and neck cancer and neurologic swallowing disturbances. Dysphagia 27:361–369CrossRefPubMed
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Mogadas S, Busch CJ, Pflug C et al (2020) Influence of radiation dose to pharyngeal constrictor muscles on late dysphagia and quality of life in patients with locally advanced oropharyngeal carcinoma. Strahlenther Onkol 196:522–529CrossRefPubMed
Metadata
Title
Verbesserte Schluckfunktion nach definitiver Radiochemotherapie bei Oro- und Hypopharynxkarzinomen durch Schonung der Musculi constrictores pharyngis
Author
Alexander M. Ziebolz
Publication date
05-02-2024
Publisher
Springer Berlin Heidelberg
Published in
Strahlentherapie und Onkologie / Issue 4/2024
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI
https://doi.org/10.1007/s00066-024-02212-y

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