Skip to main content
Top
Published in: Strahlentherapie und Onkologie 8/2018

01-08-2018 | Literatur kommentiert

Keine Überlegenheit der Protonentherapie gegenüber der IMRT beim lokal fortgeschrittenen NSCLC

Authors: Almut Dutz, Prof. Dr. Esther G. C. Troost, PD Dr. Steffen Löck

Published in: Strahlentherapie und Onkologie | Issue 8/2018

Login to get access

Auszug

Inoperable und lokal fortgeschrittene nicht-kleinzellige Bronchialkarzinome (NSCLC) werden standardgemäß mit einer simultanen Radiochemotherapie behandelt. Die Bestrahlung erfolgt dabei als intensitätsmodulierte Photonentherapie (IMRT). Planungsstudien zu Protonentherapie mit passiver Feldformung (PSPT) zeigten eine deutlich geringere Strahlenbelastung des gesunden Lungengewebes im Vergleich zur IMRT [1]. In dieser Arbeit untersuchten die Autoren die Hypothese, dass die Lungentoxizität (Strahlenpneumonitis, RP) nach PSPT geringer ist, ohne die Tumorkontrolle zu gefährden. …
Literature
1.
go back to reference Roelofs E, Engelsman M, Rasch C et al (2012) Results of a Multicentric in Silico Clinical Trial (ROCOCO): comparing radiotherapy with photons and protons for non-small cell lung cancer. J Thorac Oncol 7:165–176CrossRefPubMed Roelofs E, Engelsman M, Rasch C et al (2012) Results of a Multicentric in Silico Clinical Trial (ROCOCO): comparing radiotherapy with photons and protons for non-small cell lung cancer. J Thorac Oncol 7:165–176CrossRefPubMed
2.
go back to reference Higgins KA, O’Connell K, Liu Y et al (2017) National Cancer Database analysis of proton versus photon radiation therapy in non-small cell lung cancer. Int J Radiat Oncol Biol Phys 97:128–137CrossRefPubMed Higgins KA, O’Connell K, Liu Y et al (2017) National Cancer Database analysis of proton versus photon radiation therapy in non-small cell lung cancer. Int J Radiat Oncol Biol Phys 97:128–137CrossRefPubMed
4.
go back to reference Bradley JD, Paulus R, Komaki R et al (2015) Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study. Lancet Oncol 16:187–199CrossRefPubMedPubMedCentral Bradley JD, Paulus R, Komaki R et al (2015) Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study. Lancet Oncol 16:187–199CrossRefPubMedPubMedCentral
5.
go back to reference Senan S, Brade A, Wang LH et al (2016) PROCLAIM: randomized phase III trial of pemetrexed-cisplatin or etoposide-cisplatin plus thoracic radiation therapy followed by consolidation chemotherapy in locally advanced nonsquamous non-small-cell lung cancer. J Clin Oncol 34:953–962CrossRefPubMed Senan S, Brade A, Wang LH et al (2016) PROCLAIM: randomized phase III trial of pemetrexed-cisplatin or etoposide-cisplatin plus thoracic radiation therapy followed by consolidation chemotherapy in locally advanced nonsquamous non-small-cell lung cancer. J Clin Oncol 34:953–962CrossRefPubMed
6.
go back to reference Kong F, Ten Haken RK, Schipper M et al (2017) Effect of midtreatment PET/CT-adapted radiation therapy with concurrent chemotherapy in patients with locally advanced non-small-cell lung cancer: a phase 2 clinical trial. JAMA Oncol 3:1358–1365CrossRefPubMedPubMedCentral Kong F, Ten Haken RK, Schipper M et al (2017) Effect of midtreatment PET/CT-adapted radiation therapy with concurrent chemotherapy in patients with locally advanced non-small-cell lung cancer: a phase 2 clinical trial. JAMA Oncol 3:1358–1365CrossRefPubMedPubMedCentral
7.
go back to reference Glimelius B, Montelius A (2007) Proton beam therapy – do we need the randomised trials and can we do them? Radiother Oncol 83:105–109CrossRefPubMed Glimelius B, Montelius A (2007) Proton beam therapy – do we need the randomised trials and can we do them? Radiother Oncol 83:105–109CrossRefPubMed
9.
go back to reference Goitein M, Cox JD (2008) Should randomized clinical trials be required for proton radiotherapy? J Clin Oncol 26:175–176CrossRefPubMed Goitein M, Cox JD (2008) Should randomized clinical trials be required for proton radiotherapy? J Clin Oncol 26:175–176CrossRefPubMed
10.
go back to reference Langendijk JA, Lambin P, De Ruysscher D, Widder J, Bos M, Verheij M (2013) Selection of patients for radiotherapy with protons aiming at reduction of side effects: the model-based approach. Radiother Oncol 107:267–273CrossRefPubMed Langendijk JA, Lambin P, De Ruysscher D, Widder J, Bos M, Verheij M (2013) Selection of patients for radiotherapy with protons aiming at reduction of side effects: the model-based approach. Radiother Oncol 107:267–273CrossRefPubMed
11.
go back to reference Lühr A, von Neubeck C, Krause M, Troost EGC (2018) Relative biological effectiveness in proton beam therapy – current knowledge and future challenges. Clin Transl Radiat Oncol 9:35–41CrossRefPubMedPubMedCentral Lühr A, von Neubeck C, Krause M, Troost EGC (2018) Relative biological effectiveness in proton beam therapy – current knowledge and future challenges. Clin Transl Radiat Oncol 9:35–41CrossRefPubMedPubMedCentral
12.
go back to reference Kadane JB, Seidenfeld T (1990) Randomization in a bayesian perspective. J Stat Plan Inference 25:329–345CrossRef Kadane JB, Seidenfeld T (1990) Randomization in a bayesian perspective. J Stat Plan Inference 25:329–345CrossRef
13.
go back to reference Cheng Y, Shen Y (2005) Bayesian adaptive designs for clinical trials. Biometrika 92:633–646CrossRef Cheng Y, Shen Y (2005) Bayesian adaptive designs for clinical trials. Biometrika 92:633–646CrossRef
14.
go back to reference Yin G, Lam CK, Shi H (2017) Bayesian randomized clinical trials: from fixed to adaptive design. Contemp Clin Trials 59:77–86CrossRefPubMed Yin G, Lam CK, Shi H (2017) Bayesian randomized clinical trials: from fixed to adaptive design. Contemp Clin Trials 59:77–86CrossRefPubMed
15.
go back to reference Hoffmann AL, Troost EGC, Huizenga H, Kaanders JHAM, Bussink J (2012) Individualized dose prescription for hypofractionation in advanced non-small-cell lung cancer radiotherapy: an in silico trial. Int J Radiat Oncol Biol Phys 83:1596–1602CrossRefPubMed Hoffmann AL, Troost EGC, Huizenga H, Kaanders JHAM, Bussink J (2012) Individualized dose prescription for hypofractionation in advanced non-small-cell lung cancer radiotherapy: an in silico trial. Int J Radiat Oncol Biol Phys 83:1596–1602CrossRefPubMed
16.
go back to reference Kesarwala AH, Ko CJ, Ning H et al (2015) Intensity-modulated proton therapy for elective nodal irradiation and involved-field radiation in the definitive treatment of locally advanced non-small-cell lung cancer: a dosimetric study. Clin Lung Cancer 16:237–244CrossRefPubMed Kesarwala AH, Ko CJ, Ning H et al (2015) Intensity-modulated proton therapy for elective nodal irradiation and involved-field radiation in the definitive treatment of locally advanced non-small-cell lung cancer: a dosimetric study. Clin Lung Cancer 16:237–244CrossRefPubMed
17.
go back to reference Register SP, Zhang X, Mohan R, Chang JY (2011) Proton stereotactic body radiation therapy for clinically challenging cases of centrally and superiorly located stage I non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 80:1015–1022CrossRefPubMed Register SP, Zhang X, Mohan R, Chang JY (2011) Proton stereotactic body radiation therapy for clinically challenging cases of centrally and superiorly located stage I non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 80:1015–1022CrossRefPubMed
18.
go back to reference Zhang X, Li Y, Pan X et al (2010) Intensity-modulated proton therapy reduces the dose to normal tissue compared with intensity-modulated radiation therapy or passive scattering proton therapy and enables individualized radical radiotherapy for extensive stage IIIB non-small-cell lung cancer: a virtual clinical study. Int J Radiat Oncol Biol Phys 77:357–366CrossRefPubMed Zhang X, Li Y, Pan X et al (2010) Intensity-modulated proton therapy reduces the dose to normal tissue compared with intensity-modulated radiation therapy or passive scattering proton therapy and enables individualized radical radiotherapy for extensive stage IIIB non-small-cell lung cancer: a virtual clinical study. Int J Radiat Oncol Biol Phys 77:357–366CrossRefPubMed
19.
go back to reference Chang JY, Zhang X, Knopf A et al (2017) Consensus guidelines for implementing pencil-beam scanning proton therapy for thoracic malignancies on behalf of the PTCOG Thoracic and Lymphoma Subcommittee. Int J Radiat Oncol Biol Phys 99:41–50CrossRefPubMed Chang JY, Zhang X, Knopf A et al (2017) Consensus guidelines for implementing pencil-beam scanning proton therapy for thoracic malignancies on behalf of the PTCOG Thoracic and Lymphoma Subcommittee. Int J Radiat Oncol Biol Phys 99:41–50CrossRefPubMed
20.
go back to reference Jakobi A, Perrin R, Knopf A, Richter C (2018) Feasibility of proton pencil beam scanning treatment of free-breathing lung cancer patients. Acta Oncol 57:203–210CrossRefPubMed Jakobi A, Perrin R, Knopf A, Richter C (2018) Feasibility of proton pencil beam scanning treatment of free-breathing lung cancer patients. Acta Oncol 57:203–210CrossRefPubMed
21.
go back to reference Grassberger C, Dowdell S, Sharp G, Paganetti H (2015) Motion mitigation for lung cancer patients treated with active scanning proton therapy. Med Phys 42:2462–2469CrossRefPubMedPubMedCentral Grassberger C, Dowdell S, Sharp G, Paganetti H (2015) Motion mitigation for lung cancer patients treated with active scanning proton therapy. Med Phys 42:2462–2469CrossRefPubMedPubMedCentral
22.
go back to reference Zschaeck S, Simon M, Löck S et al (2016) PRONTOX – proton therapy to reduce acute normal tissue toxicity in locally advanced non-small-cell lung carcinomas (NSCLC): study protocol for a randomised controlled trial. Trials 17:543CrossRefPubMedPubMedCentral Zschaeck S, Simon M, Löck S et al (2016) PRONTOX – proton therapy to reduce acute normal tissue toxicity in locally advanced non-small-cell lung carcinomas (NSCLC): study protocol for a randomised controlled trial. Trials 17:543CrossRefPubMedPubMedCentral
Metadata
Title
Keine Überlegenheit der Protonentherapie gegenüber der IMRT beim lokal fortgeschrittenen NSCLC
Authors
Almut Dutz
Prof. Dr. Esther G. C. Troost
PD Dr. Steffen Löck
Publication date
01-08-2018
Publisher
Springer Berlin Heidelberg
Published in
Strahlentherapie und Onkologie / Issue 8/2018
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI
https://doi.org/10.1007/s00066-018-1321-3

Other articles of this Issue 8/2018

Strahlentherapie und Onkologie 8/2018 Go to the issue