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Published in: Strahlentherapie und Onkologie 7/2018

01-07-2018 | Literatur kommentiert

Kein Nachweis einer reduzierten Spättoxizität durch Dosisreduktion im elektiven Lymphknotenbereich in der primären Radiochemotherapie von Kopf-Hals-Tumoren

Authors: Mohammad Hreib, Prof. Dr. med. Mechthild Krause

Published in: Strahlentherapie und Onkologie | Issue 7/2018

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Ziel dieser schon einige Jahre zurückliegenden randomisierten Phase-III-Studie war es zu prüfen, ob eine Dosisreduktion der elektiven Lymphknotenregionen bei der primären Radio(chemo)therapie (RCT) von lokal fortgeschrittenen Plattenepithelkarzinomen der Kopf-Hals-Region das Ausmaß der Dysphagie reduzieren kann, ohne die lokale Tumorkontrolle zu kompromittieren. …
Literature
1.
go back to reference Bedi M, Firat S, Semenenko VA et al (2012) Elective lymph node irradiation with intensity-modulated radiotherapy: is conventional dose fractionation necessary? Int J Radiat Oncol Biol Phys 83:e87–e92CrossRefPubMed Bedi M, Firat S, Semenenko VA et al (2012) Elective lymph node irradiation with intensity-modulated radiotherapy: is conventional dose fractionation necessary? Int J Radiat Oncol Biol Phys 83:e87–e92CrossRefPubMed
2.
go back to reference Nuyts S, Lambrecht M, Duprez F et al (2013) Reduction of the dose to the elective neck in head and neck squamous cell carcinoma, a randomized clinical trial using intensity modulated radiotherapy (IMRT). Dosimetrical analysis and effect on acute toxicity. Radiother Oncol 109:323–329CrossRefPubMed Nuyts S, Lambrecht M, Duprez F et al (2013) Reduction of the dose to the elective neck in head and neck squamous cell carcinoma, a randomized clinical trial using intensity modulated radiotherapy (IMRT). Dosimetrical analysis and effect on acute toxicity. Radiother Oncol 109:323–329CrossRefPubMed
3.
go back to reference Garattini S, Bertelè V (2007) Non-inferiority trials are unethical because they disregard patients’ interests. Lancet 370:1875–1877CrossRefPubMed Garattini S, Bertelè V (2007) Non-inferiority trials are unethical because they disregard patients’ interests. Lancet 370:1875–1877CrossRefPubMed
4.
go back to reference Salama JK, Stenson KM, Kistner EO et al (2008) Induction chemotherapy and concurrent chemoradiotherapy for locoregionally advanced head and neck cancer: a multi-institutional phase II trial investigating three radiotherapy dose levels. Ann Oncol 19:1787–1794CrossRefPubMed Salama JK, Stenson KM, Kistner EO et al (2008) Induction chemotherapy and concurrent chemoradiotherapy for locoregionally advanced head and neck cancer: a multi-institutional phase II trial investigating three radiotherapy dose levels. Ann Oncol 19:1787–1794CrossRefPubMed
5.
go back to reference Langendijk JA, Doornaert P, Rietveld DH et al (2009) A predictive model for swallowing dysfunction after curative radiotherapy in head and neck cancer. Radiother Oncol 90:189–195CrossRefPubMed Langendijk JA, Doornaert P, Rietveld DH et al (2009) A predictive model for swallowing dysfunction after curative radiotherapy in head and neck cancer. Radiother Oncol 90:189–195CrossRefPubMed
6.
go back to reference Fu KK, Pajak TF, Trotti A, Jones CU, Spencer SA, Phillips TL et al (2000) A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003. Int J Radiat Oncol Biol Phys 48:7–16CrossRefPubMed Fu KK, Pajak TF, Trotti A, Jones CU, Spencer SA, Phillips TL et al (2000) A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003. Int J Radiat Oncol Biol Phys 48:7–16CrossRefPubMed
Metadata
Title
Kein Nachweis einer reduzierten Spättoxizität durch Dosisreduktion im elektiven Lymphknotenbereich in der primären Radiochemotherapie von Kopf-Hals-Tumoren
Authors
Mohammad Hreib
Prof. Dr. med. Mechthild Krause
Publication date
01-07-2018
Publisher
Springer Berlin Heidelberg
Published in
Strahlentherapie und Onkologie / Issue 7/2018
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI
https://doi.org/10.1007/s00066-018-1312-4

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