Skip to main content
Top
Published in: Strahlentherapie und Onkologie 2/2017

01-02-2017 | Literatur kommentiert

Bildgeführte intensitätsmodulierte Strahlentherapie vermindert die gastrointestinalen Spätfolgen nach Radiotherapie des Prostatakarzinoms

Authors: Dr. med. Tobias Finazzi, Prof. Dr. med. Matthias Guckenberger, MD

Published in: Strahlentherapie und Onkologie | Issue 2/2017

Login to get access

Auszug

Die perkutane Strahlentherapie ist eine etablierte Standardbehandlung des lokalisierten Prostatakarzinoms. Wortel et al. verglichen nun anhand von zwei Patientenkohorten aus zwei prospektiven Studien die Langzeitnebenwirkungen nach einer bildgeführten intensitätsmodulierten Radiotherapie (IG-IMRT) und einer dreidimensionalen (3-D) konformalen Strahlentherapie (3D-CRT), um die Hypothese einer Reduktion der Spätfolgen nach IG-IMRT zu überprüfen. …
Literature
1.
go back to reference Incrocci L, Wortel RC, Alemayehu WG et al (2016) Hypofractionated versus conventionally fractionated radiotherapy for patients with localised prostate cancer (HYPRO): Final efficacy results from a randomised, multicentre, open-label, phase 3 trial. Lancet Oncol 17:1061–1069CrossRefPubMed Incrocci L, Wortel RC, Alemayehu WG et al (2016) Hypofractionated versus conventionally fractionated radiotherapy for patients with localised prostate cancer (HYPRO): Final efficacy results from a randomised, multicentre, open-label, phase 3 trial. Lancet Oncol 17:1061–1069CrossRefPubMed
2.
go back to reference Peeters ST, Heemsbergen WD, Koper PC et al (2006) Dose-response in radiotherapy for localized prostate cancer: Results of the dutch multicenter randomized phase iii trial comparing 68 gy of radiotherapy with 78 gy. J Clin Oncol 24:1990–1996CrossRefPubMed Peeters ST, Heemsbergen WD, Koper PC et al (2006) Dose-response in radiotherapy for localized prostate cancer: Results of the dutch multicenter randomized phase iii trial comparing 68 gy of radiotherapy with 78 gy. J Clin Oncol 24:1990–1996CrossRefPubMed
3.
go back to reference Zelefsky MJ, Levin EJ, Hunt M et al (2008) Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys 70:1124–1129CrossRefPubMed Zelefsky MJ, Levin EJ, Hunt M et al (2008) Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys 70:1124–1129CrossRefPubMed
4.
go back to reference Michalski JM, Yan Y, Watkins-Bruner D et al (2013) Preliminary toxicity analysis of 3‑dimensional conformal radiation therapy versus intensity modulated radiation therapy on the high-dose arm of the radiation therapy oncology group 0126 prostate cancer trial. Int J Radiat Oncol Biol Phys 87:932–938CrossRefPubMed Michalski JM, Yan Y, Watkins-Bruner D et al (2013) Preliminary toxicity analysis of 3‑dimensional conformal radiation therapy versus intensity modulated radiation therapy on the high-dose arm of the radiation therapy oncology group 0126 prostate cancer trial. Int J Radiat Oncol Biol Phys 87:932–938CrossRefPubMed
5.
go back to reference Luxton G, Hancock SL, Boyer AL (2004) Dosimetry and radiobiologic model comparison of imrt and 3 d conformal radiotherapy in treatment of carcinoma of the prostate. Int J Radiat Oncol Biol Phys 59:267–284CrossRefPubMed Luxton G, Hancock SL, Boyer AL (2004) Dosimetry and radiobiologic model comparison of imrt and 3 d conformal radiotherapy in treatment of carcinoma of the prostate. Int J Radiat Oncol Biol Phys 59:267–284CrossRefPubMed
6.
go back to reference Bekelman JE, Mitra N, Efstathiou J et al (2011) Outcomes after intensity-modulated versus conformal radiotherapy in older men with nonmetastatic prostate cancer. Int J Radiat Oncol Biol Phys 81:e325–e334CrossRefPubMedPubMedCentral Bekelman JE, Mitra N, Efstathiou J et al (2011) Outcomes after intensity-modulated versus conformal radiotherapy in older men with nonmetastatic prostate cancer. Int J Radiat Oncol Biol Phys 81:e325–e334CrossRefPubMedPubMedCentral
7.
go back to reference Michalski JM, Gay H, Jackson A et al (2010) Radiation dose-volume effects in radiation-induced rectal injury. Int J Radiat Oncol Biol Phys 76:S123–S129CrossRefPubMedPubMedCentral Michalski JM, Gay H, Jackson A et al (2010) Radiation dose-volume effects in radiation-induced rectal injury. Int J Radiat Oncol Biol Phys 76:S123–S129CrossRefPubMedPubMedCentral
8.
go back to reference Sveistrup J, af Rosenschold PM, Deasy JO et al (2014) Improvement in toxicity in high risk prostate cancer patients treated with image-guided intensity-modulated radiotherapy compared to 3 d conformal radiotherapy without daily image guidance. Radiat Oncol 9:44CrossRefPubMedPubMedCentral Sveistrup J, af Rosenschold PM, Deasy JO et al (2014) Improvement in toxicity in high risk prostate cancer patients treated with image-guided intensity-modulated radiotherapy compared to 3 d conformal radiotherapy without daily image guidance. Radiat Oncol 9:44CrossRefPubMedPubMedCentral
9.
go back to reference Zelefsky MJ, Kollmeier M, Cox B et al (2012) Improved clinical outcomes with high-dose image guided radiotherapy compared with non-igrt for the treatment of clinically localized prostate cancer. Int J Radiat Oncol Biol Phys 84:125–129CrossRefPubMed Zelefsky MJ, Kollmeier M, Cox B et al (2012) Improved clinical outcomes with high-dose image guided radiotherapy compared with non-igrt for the treatment of clinically localized prostate cancer. Int J Radiat Oncol Biol Phys 84:125–129CrossRefPubMed
10.
go back to reference Fiorino C, Valdagni R, Rancati T et al (2009) Dose-volume effects for normal tissues in external radiotherapy: Pelvis. Radiother Oncol 93:153–167CrossRefPubMed Fiorino C, Valdagni R, Rancati T et al (2009) Dose-volume effects for normal tissues in external radiotherapy: Pelvis. Radiother Oncol 93:153–167CrossRefPubMed
11.
go back to reference McNair HA, Hansen VN, Parker CC et al (2008) A comparison of the use of bony anatomy and internal markers for offline verification and an evaluation of the potential benefit of online and offline verification protocols for prostate radiotherapy. Int J Radiat Oncol Biol Phys 71:41–50CrossRefPubMed McNair HA, Hansen VN, Parker CC et al (2008) A comparison of the use of bony anatomy and internal markers for offline verification and an evaluation of the potential benefit of online and offline verification protocols for prostate radiotherapy. Int J Radiat Oncol Biol Phys 71:41–50CrossRefPubMed
12.
go back to reference Nijkamp J, Pos FJ, Nuver TT et al (2008) Adaptive radiotherapy for prostate cancer using kilovoltage cone-beam computed tomography: First clinical results. Int J Radiat Oncol Biol Phys 70:75–82CrossRefPubMed Nijkamp J, Pos FJ, Nuver TT et al (2008) Adaptive radiotherapy for prostate cancer using kilovoltage cone-beam computed tomography: First clinical results. Int J Radiat Oncol Biol Phys 70:75–82CrossRefPubMed
13.
go back to reference de Boer HC, van Os MJ, Jansen PP et al (2005) Application of the no action level (nal) protocol to correct for prostate motion based on electronic portal imaging of implanted markers. Int J Radiat Oncol Biol Phys 61:969–983CrossRefPubMed de Boer HC, van Os MJ, Jansen PP et al (2005) Application of the no action level (nal) protocol to correct for prostate motion based on electronic portal imaging of implanted markers. Int J Radiat Oncol Biol Phys 61:969–983CrossRefPubMed
14.
go back to reference Wortel RC, Incrocci L, Pos FJ et al (2015) Acute toxicity after image-guided intensity modulated radiation therapy compared to 3 d conformal radiation therapy in prostate cancer patients. Int J Radiat Oncol Biol Phys 91:737–744CrossRefPubMed Wortel RC, Incrocci L, Pos FJ et al (2015) Acute toxicity after image-guided intensity modulated radiation therapy compared to 3 d conformal radiation therapy in prostate cancer patients. Int J Radiat Oncol Biol Phys 91:737–744CrossRefPubMed
15.
go back to reference Wortel RC, Witte MG, van der Heide UA et al (2015) Dose-surface maps identifying local dose-effects for acute gastrointestinal toxicity after radiotherapy for prostate cancer. Radiother Oncol 117:515–520CrossRefPubMed Wortel RC, Witte MG, van der Heide UA et al (2015) Dose-surface maps identifying local dose-effects for acute gastrointestinal toxicity after radiotherapy for prostate cancer. Radiother Oncol 117:515–520CrossRefPubMed
Metadata
Title
Bildgeführte intensitätsmodulierte Strahlentherapie vermindert die gastrointestinalen Spätfolgen nach Radiotherapie des Prostatakarzinoms
Authors
Dr. med. Tobias Finazzi
Prof. Dr. med. Matthias Guckenberger, MD
Publication date
01-02-2017
Publisher
Springer Berlin Heidelberg
Published in
Strahlentherapie und Onkologie / Issue 2/2017
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI
https://doi.org/10.1007/s00066-016-1088-3

Other articles of this Issue 2/2017

Strahlentherapie und Onkologie 2/2017 Go to the issue