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Strahlentherapie und Onkologie
Published in: Strahlentherapie und Onkologie 8/2015

01-08-2015 | Literatur kommentiert

Hormonentzug allein ist nicht genug

Langzeitdaten bestätigen den Überlebensvorteil durch eine zusätzliche Bestrahlung bei Prostatakarzinom

Author: Prof. Dr. med. Stefan Höcht

Published in: Strahlentherapie und Onkologie | Issue 8/2015

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Auszug

Die Arbeit ist die abschließende Publikation der Studie NCIC PR.3/MRC PR07/Intergoup T94-0110, die bei der Erstpublikation im Jahr 2011 [1] in der geplanten Interimsanalyse nach zwei Drittel der erwarteten Ereignisse bereits einen Überlebensvorteil für die zusätzlich zur Hormontherapie bestrahlten Prostatakarzinompatienten gezeigt hatte. …
Literature
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Warde P, Mason M, Ding K, Kirkbride P, Brundage M, Cowan R, Gospodarowicz M, Sanders K, Kostashuk E, Swanson G, Barber J, Hiltz A, Parmar M, Sathya J, Anderson J, Hayter C, Hetherington J, Sydes M, Parulekar W (2011) Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised phase 3 trial. Lancet 378:2104–2111
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Mason M, Parulekar W, Sydes M, Brundage M, Kirkbride P, Gospodarowicz M, Cowan R, Kostashuk E, Anderson J, Swanson G, Parmar M, Hayter C, Jovic G, Hiltz A, Hetherington J, Sathya J, Barber J, McKenzie M, El-Sharkawi S, Souhami L, Hardman P, Chen B, Warde P (2015) Final report of the intergroup randomized study of combined androgen-deprivation therapy plus radiotherapy versus androgen-deprivation therapy alone in locally advanced prostate cancer. J Clin Oncol. (2015 Feb 17. pii: JCO.2014.57.7510)
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Widmark A, Klepp O, Solberg A, Damber J, Angelsen A, Fransson P, Lund J, Tasdemir I, Hoyer M, Wiklund F, Fosså S, Scandinavian Prostate Cancer Group Study 7, Swedish Association for Urological Oncology 3 (2009) Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial. Lancet 373:301–308
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Mottet N, Peneau M, Mazeron J, Molinie V, Richaud P (2012) Addition of radiotherapy to long-term androgen deprivation in locally advanced prostate cancer: an open randomised phase 3 trial. Eur Urol 62:213–219
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Zapatero A, Guerrero A, Maldonado X, Alvarez A, Segundo C, Rodríguez M, Macias V, Olive A, Casas F, Boladeras A, Martín de Vidales C, Vazquez de la Torre M, Villà S, Perez de la Haza A, Calvo F (2015) High-dose radiotherapy with short-term or long-term androgen deprivation in localised prostate cancer (DART01/05 GICOR): A randomised controlled phase 3 trial. Lancet Oncol. doi:10.1016/S1470-2045(15)70045-8
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Bekelman J, Mitra N, Handorf E, Uzzo R, Hahn S, Polsky D, Armstrong K (2015) Effectiveness of androgen-deprivation therapy and radiotherapy for older men with locally advanced prostate cancer. J Clin Oncol 33:716–722PubMedCrossRef
Metadata
Title
Hormonentzug allein ist nicht genug
Langzeitdaten bestätigen den Überlebensvorteil durch eine zusätzliche Bestrahlung bei Prostatakarzinom
Author
Prof. Dr. med. Stefan Höcht
Publication date
01-08-2015
Publisher
Springer Berlin Heidelberg
Published in
Strahlentherapie und Onkologie / Issue 8/2015
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI
https://doi.org/10.1007/s00066-015-0851-1

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