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01-06-2014 | Original article

Stereotactic radiosurgery for treatment of brain metastases

A report of the DEGRO Working Group on Stereotactic Radiotherapy

Authors: Prof. Dr. Martin Kocher, M.D., Andrea Wittig, M.D., Marc Dieter Piroth, M.D., Harald Treuer, Ph.D., Heinrich Seegenschmiedt, M.D., Maximilian Ruge, M.D., Anca-Ligia Grosu, M.D., Matthias Guckenberger, M.D.

Published in: Strahlentherapie und Onkologie | Issue 6/2014

Abstract

Background

This report from the Working Group on Stereotaktische Radiotherapie of the German Society of Radiation Oncology (Deutsche Gesellschaft für Radioonkologie, DEGRO) provides recommendations for the use of stereotactic radiosurgery (SRS) on patients with brain metastases. It considers existing international guidelines and details them where appropriate.

Results and discussion

The main recommendations are: Patients with solid tumors except germ cell tumors and small-cell lung cancer with a life expectancy of more than 3 months suffering from a single brain metastasis of less than 3 cm in diameter should be considered for SRS. Especially when metastases are not amenable to surgery, are located in the brain stem, and have no mass effect, SRS should be offered to the patient. For multiple (two to four) metastases—all less than 2.5 cm in diameter—in patients with a life expectancy of more than 3 months, SRS should be used rather than whole-brain radiotherapy (WBRT). Adjuvant WBRT after SRS for both single and multiple (two to four) metastases increases local control and reduces the frequency of distant brain metastases, but does not prolong survival when compared with SRS and salvage treatment. As WBRT carries the risk of inducing neurocognitive damage, it seems reasonable to withhold WBRT for as long as possible.

Conclusion

A single (marginal) dose of 20 Gy is a reasonable choice that balances the effect on the treated lesion (local control, partial remission) against the risk of late side effects (radionecrosis). Higher doses (22–25 Gy) may be used for smaller (< 1 cm) lesions, while a dose reduction to 18 Gy may be necessary for lesions greater than 2.5–3 cm. As the infiltration zone of the brain metastases is usually small, the GTV–CTV (gross tumor volume–clinical target volume) margin should be in the range of 0–1 mm. The CTV–PTV (planning target volume) margin depends on the treatment technique and should lie in the range of 0–2 mm. Distant brain recurrences fulfilling the aforementioned criteria can be treated with SRS irrespective of previous WBRT.

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Title: Stereotactic radiosurgery for treatment of brain metastases
A report of the DEGRO Working Group on Stereotactic Radiotherapy
Authors: Prof. Dr. Martin Kocher, M.D.
Andrea Wittig, M.D.
Marc Dieter Piroth, M.D.
Harald Treuer, Ph.D.
Heinrich Seegenschmiedt, M.D.
Maximilian Ruge, M.D.
Anca-Ligia Grosu, M.D.
Matthias Guckenberger, M.D.
Publication date: 01-06-2014
Publisher: Springer Berlin Heidelberg
Published in: Strahlentherapie und Onkologie / Issue 6/2014
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-014-0648-7

ACC 2024 Congress

Springer Medicine

Stereotactic radiosurgery for treatment of brain metastases

A report of the DEGRO Working Group on Stereotactic Radiotherapy

Abstract

Background

Results and discussion

Conclusion

ACC 2024 Congress

Springer Medicine

Abstract

Background

Results and discussion

Conclusion

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