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Strahlentherapie und Onkologie

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01-06-2013 | Original article

Effect of concurrent chemotherapy and hyperthermia on outcome of preoperative radiotherapy of high-risk soft tissue sarcomas

Authors: F. Eckert, C. Gani, T. Kluba, F. Mayer, H.-G. Kopp, D. Zips, M. Bamberg, A.-C. Müller

Published in: Strahlentherapie und Onkologie | Issue 6/2013

Abstract

Background and purpose

As treatment results for high-risk soft tissue sarcoma are still disappointing, treatment intensification is warranted. We performed a retrospective analysis of multimodal preoperative treatment to evaluate the additional effect of concurrent chemotherapy and/or locoregional hyperthermia in comparison to radiotherapy alone.

Patients and methods

Between 1999 and 2011, 28 patients were treated with neoadjuvant radiotherapy to a median 45 Gy for high-risk soft tissue sarcoma. All tumors were deep-seated and grade 2 or 3, 86% (n = 24) larger than 5 cm. Multimodal treatment (n = 12) consisted of ifosfamide (n = 7), locoregional hyperthermia (n = 3), or both modalities (n = 2) concurrent to radiotherapy.

Results

Prognostic factors (grade, size, histology, location) were balanced in the groups with and without concurrent multimodal treatment. There was a significant improvement of disease-specific survival (100% vs. 70% at 3 years, p = 0.03) with multimodal treatment. Distant metastases-free survival was influenced, but was not statistically significant. Local control and disease-free survival did not differ in the two groups.

Conclusion

Our data suggest that multimodal treatment with ifosfamide and/or locoregional hyperthermia in combination with neoadjuvant radiotherapy might improve outcome in high-risk soft tissue sarcomas.

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Title: Effect of concurrent chemotherapy and hyperthermia on outcome of preoperative radiotherapy of high-risk soft tissue sarcomas
Authors: F. Eckert
C. Gani
T. Kluba
F. Mayer
H.-G. Kopp
D. Zips
M. Bamberg
A.-C. Müller
Publication date: 01-06-2013
Publisher: Springer-Verlag
Published in: Strahlentherapie und Onkologie / Issue 6/2013
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-013-0312-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Effect of concurrent chemotherapy and hyperthermia on outcome of preoperative radiotherapy of high-risk soft tissue sarcomas

Abstract

Background and purpose

Patients and methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background and purpose

Patients and methods

Results

Conclusion

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