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Strahlentherapie und Onkologie

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01-05-2013 | Original article

Radiotherapy for carcinoma of the vagina

Immunocytochemical and cytofluorometric analysis of prognostic factors

Authors: P. Blecharz, M. Reinfuss, J. Ryś, J. Jakubowicz, P. Skotnicki, W. Wysocki

Published in: Strahlentherapie und Onkologie | Issue 5/2013

Abstract

Background and purpose

The aim of this study was to assess the potential prognostic factors in patients with primary invasive vaginal carcinoma (PIVC) treated with radical irradiation.

Patients and methods

The analysis was performed on 77 patients with PIVC treated between 1985 and 2005 in the Maria Skłodowska-Curie Memorial Institute of Oncology, Cancer Center in Krakow. A total of 36 patients (46.8 %) survived 5 years with no evidence of disease (NED). The following groups of factors were assessed for potential prognostic value: population-based (age), clinical (Karnofsky Performance Score [KPS], hemoglobin level, primary location of the vaginal lesion, macroscopic type, length of the involved vaginal wall, FIGO stage), microscopic (microscopic type, grade, mitotic index, presence of atypical mitoses, lymphatic vessels invasion, lymphocytes/plasmocytes infiltration, focal necrosis, VAIN-3), immunohistochemical (protein p53 expression, MIB-1 index), cytofluorometric (ploidity, index DI, S-phase fraction, proliferation index SG2M) factors.

Results

Significantly better 5-year NED was observed in patients: < 60 years, KPS ≥ 80, FIGO stage I and II, grade G1–2, MIB-1 index < 70, S-phase fraction < 10, and proliferation index < 25. Independent factors for better prognosis in the multivariate Cox analysis were age < 60 years, FIGO stage I or II, and MIB-1 index < 70.

Conclusion

Independent prognostic factors in the radically irradiated PIVC patients were as follows: age, FIGO stage, MIB-1 index.

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Title: Radiotherapy for carcinoma of the vagina
Immunocytochemical and cytofluorometric analysis of prognostic factors
Authors: P. Blecharz
M. Reinfuss
J. Ryś
J. Jakubowicz
P. Skotnicki
W. Wysocki
Publication date: 01-05-2013
Publisher: Springer-Verlag
Published in: Strahlentherapie und Onkologie / Issue 5/2013
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-012-0291-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Radiotherapy for carcinoma of the vagina

Immunocytochemical and cytofluorometric analysis of prognostic factors

Abstract

Background and purpose

Patients and methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background and purpose

Patients and methods

Results

Conclusion

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