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Strahlentherapie und Onkologie

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01-10-2012 | Original article

Benign painful elbow syndrome

First results of a single center prospective randomized radiotherapy dose optimization trial

Authors: PD Dr. O.J. Ott, S. Hertel, U.S. Gaipl, B. Frey, M. Schmidt, R. Fietkau

Published in: Strahlentherapie und Onkologie | Issue 10/2012

Abstract

Background and purpose

The goal of the present study was to evaluate the efficacy of two different dose-fractionation schedules for radiotherapy (RT) of patients with painful elbow syndrome.

Patients and methods

Between February 2006 and February 2010, 199 consecutive evaluable patients were recruited for this prospective randomized trial. All patients received RT in orthovoltage technique. One RT course consisted of 6 single fractions/3 weeks. In case of insufficient remission of pain after 6 weeks a second radiation series was performed. Patients were randomly assigned to receive either single doses of 0.5 or 1.0 Gy. Endpoint was pain reduction. Pain was measured before, right after, and 6 weeks after RT by a visual analogue scale (VAS) and a comprehensive pain score (CPS).

Results

The overall response rate for all patients was 80% direct after and 91% 6 weeks after RT. The mean VAS values before, after and 6 weeks after treatment for the 0.5 and 1.0 Gy groups were 59.6 ± 20.2 and 55.7 ± 18.0 (p = 0.463), 32.1 ± 24.5 and 34.4 ± 22.5 (p = 0.256), and 27.0 ± 27.7 and 23.5 ± 21.6 (p = 0.818). The mean CPS before, after, and 6 weeks after treatment was 8.7 ± 2.9 and 8.1 ± 3.1 (p = 0.207), 4.5 ± 3.2 and 5.0 ± 3.4 (p = 0.507), 3.9 ± 3.6 and 2.8 ± 2.8 (p = 0.186), respectively. No statistically significant differences between the two single dose trial arms for early (p = 0.103) and delayed response (p = 0.246) were found.

Conclusion

RT is an effective treatment option for the management of benign painful elbow syndrome. For radiation protection reasons the dose for a RT series is recommended not to exceed 3.0 Gy.

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Title: Benign painful elbow syndrome
First results of a single center prospective randomized radiotherapy dose optimization trial
Authors: PD Dr. O.J. Ott
S. Hertel
U.S. Gaipl
B. Frey
M. Schmidt
R. Fietkau
Publication date: 01-10-2012
Publisher: Springer-Verlag
Published in: Strahlentherapie und Onkologie / Issue 10/2012
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-012-0179-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Benign painful elbow syndrome

First results of a single center prospective randomized radiotherapy dose optimization trial

Abstract

Background and purpose

Patients and methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background and purpose

Patients and methods

Results

Conclusion

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