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Published in: Clinical Neuroradiology 4/2017

01-12-2017 | Correspondence

Contribution of QSM Imaging to the Diagnosis of the Rare Syndrome of Leukoencephalopathy with Cysts and Calcification (LCC)

Authors: Peter Raab, Martin Stangel, Heinrich Lanfermann

Published in: Clinical Neuroradiology | Issue 4/2017

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Abstract

We describe the typical computed tomography (CT) and magnetic resonance imaging (MRI) characteristics in a rare case of adult leukoencephalopathy with calcifications and cysts (LCC). In addition, we describe the specific findings of quantified susceptibility mapping (QSM) in this case, relate it to known histopathological findings, and point out possible advantages of this method.
Literature
1.
go back to reference Labrune P, Lacroix C, Goutieres F, de Laveaucoupet J, Chevalier P, Zerah M, Husson B, Landrieu P. Extensive brain calcifications, leukodystrophy, and formation of parenchymal cysts: a new progressive disorder due to diffuse cerebral microangiopathy. Neurology. 1996;46(5):1297–301.CrossRefPubMed Labrune P, Lacroix C, Goutieres F, de Laveaucoupet J, Chevalier P, Zerah M, Husson B, Landrieu P. Extensive brain calcifications, leukodystrophy, and formation of parenchymal cysts: a new progressive disorder due to diffuse cerebral microangiopathy. Neurology. 1996;46(5):1297–301.CrossRefPubMed
2.
go back to reference Nagae-Poetscher LM, Bibat G, Philippart M, Rosemberg S, Fatemi A, Lacerda MT, Costa MO, Kok F, Costa Leite C, Horska A, Barker PB, Naidu S. Leukoencephalopathy, cerebral calcifications, and cysts: new observations. Neurology. 2004;62(7):1206–9.CrossRefPubMed Nagae-Poetscher LM, Bibat G, Philippart M, Rosemberg S, Fatemi A, Lacerda MT, Costa MO, Kok F, Costa Leite C, Horska A, Barker PB, Naidu S. Leukoencephalopathy, cerebral calcifications, and cysts: new observations. Neurology. 2004;62(7):1206–9.CrossRefPubMed
3.
go back to reference Brenner C, Del Negro MC, Borigato EM, Miranda RV. Leukoencephalopathy with cerebral calcifications and cysts. Neurology. 2006;66(9):E32.CrossRefPubMed Brenner C, Del Negro MC, Borigato EM, Miranda RV. Leukoencephalopathy with cerebral calcifications and cysts. Neurology. 2006;66(9):E32.CrossRefPubMed
4.
go back to reference Corboy JR, Gault J, Kleinschmidt-DeMasters BK. An adult case of leukoencephalopathy with intracranial calcifications and cysts. Neurology. 2006;67(10):1890–2.CrossRefPubMed Corboy JR, Gault J, Kleinschmidt-DeMasters BK. An adult case of leukoencephalopathy with intracranial calcifications and cysts. Neurology. 2006;67(10):1890–2.CrossRefPubMed
5.
go back to reference Marelli C, Savoiardo M, Fini N, Bartolomei I, Marliani AF, De Gonda F, Agostinis C, Albini-Riccioli L, Marucci G, Giaccone G, Chiapparini L, Salvi F, Pareyson D. Late presentation of leucoencephalopathy with calcifications and cysts: report of two cases. J Neurol Neurosurg Psychiatr. 2008;79(11):1303–4.CrossRef Marelli C, Savoiardo M, Fini N, Bartolomei I, Marliani AF, De Gonda F, Agostinis C, Albini-Riccioli L, Marucci G, Giaccone G, Chiapparini L, Salvi F, Pareyson D. Late presentation of leucoencephalopathy with calcifications and cysts: report of two cases. J Neurol Neurosurg Psychiatr. 2008;79(11):1303–4.CrossRef
6.
go back to reference Kleinschmidt-Demasters BK, Cummings TJ, Hulette CM, Morgenlander JC, Corboy JR. Adult cases of leukoencephalopathy, cerebral calcifications, and cysts: expanding the spectrum of the disorder. J Neuropathol Exp Neurol. 2009;68(4):432–9.CrossRefPubMed Kleinschmidt-Demasters BK, Cummings TJ, Hulette CM, Morgenlander JC, Corboy JR. Adult cases of leukoencephalopathy, cerebral calcifications, and cysts: expanding the spectrum of the disorder. J Neuropathol Exp Neurol. 2009;68(4):432–9.CrossRefPubMed
7.
go back to reference Bartolini E, Bianchi A, Bartolomei I, Vella A, Sali L, Ciccarone A, Salvi F, Mascalchi M. Diffuse brain hypoperfusion in advanced leukoencephalopathy with calcifications and cysts. J Stroke Cerebrovasc Dis. 2016;25(8):e111–e113.CrossRefPubMed Bartolini E, Bianchi A, Bartolomei I, Vella A, Sali L, Ciccarone A, Salvi F, Mascalchi M. Diffuse brain hypoperfusion in advanced leukoencephalopathy with calcifications and cysts. J Stroke Cerebrovasc Dis. 2016;25(8):e111–e113.CrossRefPubMed
8.
go back to reference Schweser F, Deistung A, Lehr BW, Reichenbach JR. Differentiation between diamagnetic and paramagnetic cerebral lesions based on magnetic susceptibility mapping. Med Phys. 2010;37(10):5165–78.CrossRefPubMed Schweser F, Deistung A, Lehr BW, Reichenbach JR. Differentiation between diamagnetic and paramagnetic cerebral lesions based on magnetic susceptibility mapping. Med Phys. 2010;37(10):5165–78.CrossRefPubMed
9.
go back to reference Liu J, Liu T, de Rochefort L, Ledoux J, Khalidov I, Chen W, Tsiouris AJ, Wisnieff C, Spincemaille P, Prince MR, Wang Y. Morphology enabled dipole inversion for quantitative susceptibility mapping using structural consistency between the magnitude image and the susceptibility map. Neuroimage. 2012;59(3):2560–8.CrossRefPubMed Liu J, Liu T, de Rochefort L, Ledoux J, Khalidov I, Chen W, Tsiouris AJ, Wisnieff C, Spincemaille P, Prince MR, Wang Y. Morphology enabled dipole inversion for quantitative susceptibility mapping using structural consistency between the magnitude image and the susceptibility map. Neuroimage. 2012;59(3):2560–8.CrossRefPubMed
10.
go back to reference Liu T, Wisnieff C, Lou M, Chen W, Spincemaille P, Wang Y. Nonlinear formulation of the magnetic field to source relationship for robust quantitative susceptibility mapping. Magn Reson Med. 2013;69(2):467–76.CrossRefPubMed Liu T, Wisnieff C, Lou M, Chen W, Spincemaille P, Wang Y. Nonlinear formulation of the magnetic field to source relationship for robust quantitative susceptibility mapping. Magn Reson Med. 2013;69(2):467–76.CrossRefPubMed
Metadata
Title
Contribution of QSM Imaging to the Diagnosis of the Rare Syndrome of Leukoencephalopathy with Cysts and Calcification (LCC)
Authors
Peter Raab
Martin Stangel
Heinrich Lanfermann
Publication date
01-12-2017
Publisher
Springer Berlin Heidelberg
Published in
Clinical Neuroradiology / Issue 4/2017
Print ISSN: 1869-1439
Electronic ISSN: 1869-1447
DOI
https://doi.org/10.1007/s00062-017-0586-8

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