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Clinical Neuroradiology

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01-06-2017 | Original Article

Langerhans Cell Histiocytosis of the Temporal Bone with Otic Capsule Involvement

Authors: J. M. Blumberg, A. Malhotra, X. Wu, R. K. Virk, J. F. Kveton, E. M. Michaelides

Published in: Clinical Neuroradiology | Issue 2/2017

Abstract

Introduction

This study is conducted to demonstrate that destructive lesions of the otic capsule by Langerhans cell histiocytosis (LCH) causing both radiographic and audiologic findings can be completely reversed with adequate treatment. Retrospective case review and analysis of clinical and imaging data were obtained as part of the diagnosis and treatment of patients with LCH of the temporal bone.

Methods

With Institutional Review Board (IRB) approval, cases of LCH involving the temporal bone were searched for within the institutional databases. Criteria for inclusion was histologic diagnosis of LCH and pretreatment computed tomography (CT) demonstrating temporal bone and/or otic capsule involvement and posttreatment follow-up CT/magnetic resonance imaging (MRI) scans obtained at least 6 months after starting treatment.

Results

We report eight cases of LCH of the temporal bone with three demonstrating otic capsule involvement radiographically and/or clinically. Review of posttreatment imaging revealed all three patients had complete restoration of the bony labyrinthine architecture and near or complete restoration of their hearing.

Conclusions

Though LCH of the temporal bone is a common site within the spectrum of the disease, involvement of the otic capsule remains rare. Here, we report the largest series of otic capsule involvement by LCH and investigate whether both architecture and hearing are recovered with appropriate treatment. Lastly, restoration of the bony architecture of the labyrinth suggests the mechanism of LCH is demineralization and not ablative.

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Title: Langerhans Cell Histiocytosis of the Temporal Bone with Otic Capsule Involvement
Authors: J. M. Blumberg
A. Malhotra
X. Wu
R. K. Virk
J. F. Kveton
E. M. Michaelides
Publication date: 01-06-2017
Publisher: Springer Berlin Heidelberg
Published in: Clinical Neuroradiology / Issue 2/2017
Print ISSN: 1869-1439
Electronic ISSN: 1869-1447
DOI: https://doi.org/10.1007/s00062-015-0461-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Langerhans Cell Histiocytosis of the Temporal Bone with Otic Capsule Involvement

Abstract

Introduction

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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