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Clinical Neuroradiology
Published in: Clinical Neuroradiology 4/2014

01-12-2014 | Original Article

Definition of Ktrans and FA Thresholds for Better Assessment of Experimental Glioma Using High-field MRI: A Feasibility Study

Authors: T. Engelhorn, MD, M. A. Schwarz, MSc, A. Hess, PhD, L. Budinsky, PhD, P. Pitann, I. Eyüpoglu, PhD, A. Doerfler, PhD

Published in: Clinical Neuroradiology | Issue 4/2014

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Abstract

Purpose

To define Ktrans and fractional anisotropy (FA) thresholds in correlation to histology for improved magnetic resonance imaging (MRI) tumor assessment in an animal model of brain glioma.

Methods

Twelve rats underwent 4.7 T MRI at day 10 after tumor implantation. Anatomical scans (T2, T1 at 8 min after double dose contrast application) as well as dynamic contrast-enhanced (DCE) imaging with calculation of Ktrans and diffusion tensor imaging (DTI) with calculation of FA were performed. T2- and T1-derived tumor volumes were calculated and thresholds for Ktrans and FA were defined for best MRI tumor assessment correlated to histology.

Results

Tumor volumes were 159 ± 14 mm3 (histology), 126 ± 26 mm3 (T1 with contrast, r = 0.76), and 153 ± 12 mm3 (T2, r = 0.84), respectively. Ktrans- and FA-derived tumor volumes were 160 ± 16 mm3 (for Ktrans ³ 0.04 min−1, r = 0.94), and 159 ± 14 mm3 (for FA £ 0.14, r = 0.96), respectively.

Conclusions

DCE-MRI and DTI with calculation of Ktrans and FA maps allow very precise brain glioma assessment comparable to histology if established thresholds for the given tumor model are used.
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Metadata
Title
Definition of Ktrans and FA Thresholds for Better Assessment of Experimental Glioma Using High-field MRI: A Feasibility Study
Authors
T. Engelhorn, MD
M. A. Schwarz, MSc
A. Hess, PhD
L. Budinsky, PhD
P. Pitann
I. Eyüpoglu, PhD
A. Doerfler, PhD
Publication date
01-12-2014
Publisher
Springer Berlin Heidelberg
Published in
Clinical Neuroradiology / Issue 4/2014
Print ISSN: 1869-1439
Electronic ISSN: 1869-1447
DOI
https://doi.org/10.1007/s00062-013-0257-3

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