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Published in: Current Sleep Medicine Reports 2/2016

01-06-2016 | Sleep Related Breathing Disorders (T Lee-Chiong, Section Editor)

Home- vs. Laboratory-Based Management Of OSA: An Economic Review

Authors: Ken He, Richard Kim, Vishesh K. Kapur

Published in: Current Sleep Medicine Reports | Issue 2/2016

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Abstract

Obstructive sleep apnea (OSA) is a common condition that impairs quality of life and health. Diagnosis and treatment of OSA is cost-effective; however, the economics of various management strategies remain to be defined. Home sleep apnea tests (HSAT) provide an alternative to laboratory based polysomnography (PSG) and are less expensive than PSG on a per test basis; however, when utilized within a framework that has been demonstrated to provide comparable clinical outcomes, home testing pathways incur additional costs to compensate for failed studies and lower diagnostic accuracy. A cost-minimization analysis from a randomized controlled trial showed that the cost advantage of a home management pathway narrowed significantly when these additional costs are considered. Further, when the actual costs of providing HSAT rather than what is reimbursed by insurance were considered, the cost advantage was further attenuated. A comprehensive cost-effectiveness analysis (CEA), favored a lab over a home approach based on modeling that projected that the costs of erroneous diagnosis over a long time span for the home approach outweighed lower test costs. Studies have identified the following factors that influence cost-effectiveness of home-based management: cost of untreated OSA, prevalence of OSA, performance characteristics of the selected test, time horizon, and whether backup PSG is used for failed HSAT. More clinical studies are needed to provide the inputs for more robust CEA regarding this issue.
Literature
1.
go back to reference Young T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med. 2002;165(9):1217–39.CrossRefPubMed Young T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med. 2002;165(9):1217–39.CrossRefPubMed
4.
go back to reference Epstein LJ, Kristo D, Strollo Jr PJ, et al. Clinical guideline for evaluation, management, and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med. 2009;5(3):263–76.PubMed Epstein LJ, Kristo D, Strollo Jr PJ, et al. Clinical guideline for evaluation, management, and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med. 2009;5(3):263–76.PubMed
5.
go back to reference Hossain JL, Shapiro CM. The prevalence, cost implications, and management of sleep disorders: an overview. Sleep Breath. 2002;6(2):85–102.CrossRefPubMed Hossain JL, Shapiro CM. The prevalence, cost implications, and management of sleep disorders: an overview. Sleep Breath. 2002;6(2):85–102.CrossRefPubMed
6.
go back to reference Flemons WW, Douglas NJ, Kuna ST, et al. Access to diagnosis and treatment of patients with suspected sleep apnea. Am J Respir Crit Care Med. 2004;169(6):668–72.CrossRefPubMed Flemons WW, Douglas NJ, Kuna ST, et al. Access to diagnosis and treatment of patients with suspected sleep apnea. Am J Respir Crit Care Med. 2004;169(6):668–72.CrossRefPubMed
7.
go back to reference BaHammam AS, ALAnbay E, Alrajhi N, Olaish AH. The success rate of split-night polysomnography and its impact on continuous positive airway pressure compliance. Ann Thorac Med. 2015;10(4):274–8.PubMedPubMedCentral BaHammam AS, ALAnbay E, Alrajhi N, Olaish AH. The success rate of split-night polysomnography and its impact on continuous positive airway pressure compliance. Ann Thorac Med. 2015;10(4):274–8.PubMedPubMedCentral
8.
go back to reference Khawaja IS, Olson EJ, van der Walt C, et al. Diagnostic accuracy of split-night polysomnograms. J Clin Sleep Med. 2010;6(4):357–62.PubMedPubMedCentral Khawaja IS, Olson EJ, van der Walt C, et al. Diagnostic accuracy of split-night polysomnograms. J Clin Sleep Med. 2010;6(4):357–62.PubMedPubMedCentral
9.
go back to reference Deutsch PA, Simmons MS, Wallace JM. Cost-effectiveness of split-night polysomnography and home studies in the evaluation of obstructive sleep apnea syndrome. J Clin Sleep Med. 2006;2(2):145–53.PubMed Deutsch PA, Simmons MS, Wallace JM. Cost-effectiveness of split-night polysomnography and home studies in the evaluation of obstructive sleep apnea syndrome. J Clin Sleep Med. 2006;2(2):145–53.PubMed
10.
go back to reference Collop N, Anderson WM, Boehlecke B, et al. Clinical guidelines for the use of unattended portable monitors in the diagnosis of obstructive sleep apnea in adult patients. J Clin Sleep Med. 2007;3(7):737–47.PubMed Collop N, Anderson WM, Boehlecke B, et al. Clinical guidelines for the use of unattended portable monitors in the diagnosis of obstructive sleep apnea in adult patients. J Clin Sleep Med. 2007;3(7):737–47.PubMed
11.
go back to reference Bierer GB, Ryden A, Aysola RS. Advanced positive airway pressure modalities. Curr Sleep Med Rep. 2015;1:257–64.CrossRef Bierer GB, Ryden A, Aysola RS. Advanced positive airway pressure modalities. Curr Sleep Med Rep. 2015;1:257–64.CrossRef
12.
go back to reference Kushida CA, Berry RB, Blau A, et al. Positive airway pressure initiation: a randomized controlled trial to assess the impact of therapy mode and titration process on efficacy, adherence, and outcomes. Sleep. 2011;34(8):1083–92.PubMedPubMedCentral Kushida CA, Berry RB, Blau A, et al. Positive airway pressure initiation: a randomized controlled trial to assess the impact of therapy mode and titration process on efficacy, adherence, and outcomes. Sleep. 2011;34(8):1083–92.PubMedPubMedCentral
13.
go back to reference Nolan GM, Doherty LS, Mc Nicholas WT. Auto-adjusting versus fixed positive pressure therapy in mild to moderate obstructive sleep apnea. Sleep. 2007;30(2):189–94.PubMed Nolan GM, Doherty LS, Mc Nicholas WT. Auto-adjusting versus fixed positive pressure therapy in mild to moderate obstructive sleep apnea. Sleep. 2007;30(2):189–94.PubMed
14.
go back to reference Mulgrew AT, Cheema R, Fleetham J, Ryan CF, Ayas NT. Efficacy and patient satisfaction with autoadjusting CPAP with variable expiratory pressure vs standard CPAP: a two-night randomized crossover trial. Sleep Breath. 2007;11(1):31–7.CrossRefPubMedPubMedCentral Mulgrew AT, Cheema R, Fleetham J, Ryan CF, Ayas NT. Efficacy and patient satisfaction with autoadjusting CPAP with variable expiratory pressure vs standard CPAP: a two-night randomized crossover trial. Sleep Breath. 2007;11(1):31–7.CrossRefPubMedPubMedCentral
15.
go back to reference Fietze I, Glos M, Moebus I, Witt C, Penzel T, Baumann G. Automatic pressure titration with APAP is as effective as manual titration with CPAP in patients with obstructive sleep apnea. Respiration. 2007;74(3):279–86.CrossRefPubMed Fietze I, Glos M, Moebus I, Witt C, Penzel T, Baumann G. Automatic pressure titration with APAP is as effective as manual titration with CPAP in patients with obstructive sleep apnea. Respiration. 2007;74(3):279–86.CrossRefPubMed
16.
go back to reference Morgenthaler TI, Aurora RN, Brown T, Standards of Practice Committee of the AASM, et al. American Academy of Sleep Medicine. Practice parameters for the use of autotitrating continuous positive airway pressure devices for titrating pressures and treating adult patients with obstructive sleep apnea syndrome: an update for 2007. An American Academy of Sleep Medicine report. Sleep. 2008;31(1):141–7.PubMedPubMedCentral Morgenthaler TI, Aurora RN, Brown T, Standards of Practice Committee of the AASM, et al. American Academy of Sleep Medicine. Practice parameters for the use of autotitrating continuous positive airway pressure devices for titrating pressures and treating adult patients with obstructive sleep apnea syndrome: an update for 2007. An American Academy of Sleep Medicine report. Sleep. 2008;31(1):141–7.PubMedPubMedCentral
17.
go back to reference Skomro RP, Gjevre J, Reid J, et al. Outcomes of home-based diagnosis and treatment of obstructive sleep apnea. Chest. 2010;138(2):257–63.CrossRefPubMed Skomro RP, Gjevre J, Reid J, et al. Outcomes of home-based diagnosis and treatment of obstructive sleep apnea. Chest. 2010;138(2):257–63.CrossRefPubMed
18.
go back to reference Kuna ST, Gurubhagavatula I, Maislin G, et al. Noninferiority of functional outcome in ambulatory management of obstructive sleep apnea. Am J Respir Crit Care Med. 2011;183(9):1238–44.CrossRefPubMed Kuna ST, Gurubhagavatula I, Maislin G, et al. Noninferiority of functional outcome in ambulatory management of obstructive sleep apnea. Am J Respir Crit Care Med. 2011;183(9):1238–44.CrossRefPubMed
19.
go back to reference Berry RB, Hill G, Thompson L, et al. Portable monitoring and autotitration versus polysomnography for the diagnosis and treatment of sleep apnea. Sleep. 2008;31(10):1423–31.PubMedPubMedCentral Berry RB, Hill G, Thompson L, et al. Portable monitoring and autotitration versus polysomnography for the diagnosis and treatment of sleep apnea. Sleep. 2008;31(10):1423–31.PubMedPubMedCentral
20.••
go back to reference Rosen CL, Auckley DA, Benca R, et al. A multisite randomized trial of portable sleep studies and positive airway pressure autotitration versus laboratory-based polysomnography for the diagnosis and treatment of obstructive sleep apnea: the HomePAP study. Sleep. 2012;35(6):757–67. This randomized trial showed that home-based diagnosis and treatment of OSA was non-inferior to lab-based PSG and PAP titration when carried out in the context of an appropriate clinical population and management pathway.CrossRefPubMedPubMedCentral Rosen CL, Auckley DA, Benca R, et al. A multisite randomized trial of portable sleep studies and positive airway pressure autotitration versus laboratory-based polysomnography for the diagnosis and treatment of obstructive sleep apnea: the HomePAP study. Sleep. 2012;35(6):757–67. This randomized trial showed that home-based diagnosis and treatment of OSA was non-inferior to lab-based PSG and PAP titration when carried out in the context of an appropriate clinical population and management pathway.CrossRefPubMedPubMedCentral
21.
go back to reference Kapur V, Blough DK, Sandblom RE, Hert R, de Maine JB, Sullivan SD, et al. The medical cost of undiagnosed sleep apnea. Sleep. 1999;22(6):749–55.PubMed Kapur V, Blough DK, Sandblom RE, Hert R, de Maine JB, Sullivan SD, et al. The medical cost of undiagnosed sleep apnea. Sleep. 1999;22(6):749–55.PubMed
22.
go back to reference Tarasiuk A, Reuveni H. The economic impact of obstructive sleep apnea. Curr Opin Pulm Med. 2013;19(6):639–44.CrossRefPubMed Tarasiuk A, Reuveni H. The economic impact of obstructive sleep apnea. Curr Opin Pulm Med. 2013;19(6):639–44.CrossRefPubMed
23.
go back to reference Kapur VK. Obstructive sleep apnea: diagnosis, epidemiology, and economics. Respir Care. 2010;55(9):1155–67.PubMed Kapur VK. Obstructive sleep apnea: diagnosis, epidemiology, and economics. Respir Care. 2010;55(9):1155–67.PubMed
24.
go back to reference Ayas NT, FitzGerald JM, Fleetham JA, et al. Cost-effectiveness of continuous positive airway pressure therapy for moderate to severe obstructive sleep apnea/hypopnea. Arch Intern Med. 2006;166(9):977–84.CrossRefPubMed Ayas NT, FitzGerald JM, Fleetham JA, et al. Cost-effectiveness of continuous positive airway pressure therapy for moderate to severe obstructive sleep apnea/hypopnea. Arch Intern Med. 2006;166(9):977–84.CrossRefPubMed
25.
go back to reference Neumann PJ, Cohen JT, Weinstein MC. Updating cost-effectiveness—the curious resilience of the $50,000-per-QALY threshold. N Engl J Med. 2014;371(9):796–7.CrossRefPubMed Neumann PJ, Cohen JT, Weinstein MC. Updating cost-effectiveness—the curious resilience of the $50,000-per-QALY threshold. N Engl J Med. 2014;371(9):796–7.CrossRefPubMed
26.••
go back to reference Pietzsch JB, Garner A, Cipriano LE, et al. An integrated health-economic analysis of diagnostic and therapeutic strategies in the treatment of moderate-to-severe obstructive sleep apnea. Sleep. 2011;34(6):695–709. This cost-effectiveness analysis modeled different OSA diagnostic and treatment strategies, and showed full-night PSG with CPAP therapy was most cost-effective.CrossRefPubMedPubMedCentral Pietzsch JB, Garner A, Cipriano LE, et al. An integrated health-economic analysis of diagnostic and therapeutic strategies in the treatment of moderate-to-severe obstructive sleep apnea. Sleep. 2011;34(6):695–709. This cost-effectiveness analysis modeled different OSA diagnostic and treatment strategies, and showed full-night PSG with CPAP therapy was most cost-effective.CrossRefPubMedPubMedCentral
27.•
go back to reference Bianchi MT, Hershman S, Bahadoran M, et al. The challenge of undiagnosed sleep apnea in low-risk populations: a decision analysis. Mil Med. 2014;179(8 Suppl):47–54. This decision analysis modeled different OSA diagnostic strategies in a low-risk military population and showed HSAT in all comers as the preferred strategy over screening inventory followed by PSG.CrossRefPubMed Bianchi MT, Hershman S, Bahadoran M, et al. The challenge of undiagnosed sleep apnea in low-risk populations: a decision analysis. Mil Med. 2014;179(8 Suppl):47–54. This decision analysis modeled different OSA diagnostic strategies in a low-risk military population and showed HSAT in all comers as the preferred strategy over screening inventory followed by PSG.CrossRefPubMed
28.••
go back to reference Moro M, Westover MB, Kelly J, et al. Decision modeling in sleep apnea: the critical roles of pre-test probability, cost of untreated OSA, and time horizon. J Clin Sleep Med. 2015;12:409–18. This decision analysis modeled different OSA diagnostic and treatment strategies, and showed how OSA related factors influenced the best strategy. The optimal diagnostic approach to uncomplicated OSA depends on pre-test probability, cost of untreated OSA, and time horizon.CrossRef Moro M, Westover MB, Kelly J, et al. Decision modeling in sleep apnea: the critical roles of pre-test probability, cost of untreated OSA, and time horizon. J Clin Sleep Med. 2015;12:409–18. This decision analysis modeled different OSA diagnostic and treatment strategies, and showed how OSA related factors influenced the best strategy. The optimal diagnostic approach to uncomplicated OSA depends on pre-test probability, cost of untreated OSA, and time horizon.CrossRef
29.••
go back to reference Kim RD, Kapur VK, Redline-Bruch J, et al. An economic evaluation of home versus laboratory-based diagnosis of obstructive sleep apnea. Sleep. 2015;38(7):1027–37. This cost-minimization analysis based on HomePAP study data showed that for payers, a home-based diagnostic pathway for obstructive sleep apnea with robust patient support incurs fewer costs than a laboratory-based pathway. For providers, costs are comparable if not higher, resulting in a negative operating margin.CrossRefPubMedPubMedCentral Kim RD, Kapur VK, Redline-Bruch J, et al. An economic evaluation of home versus laboratory-based diagnosis of obstructive sleep apnea. Sleep. 2015;38(7):1027–37. This cost-minimization analysis based on HomePAP study data showed that for payers, a home-based diagnostic pathway for obstructive sleep apnea with robust patient support incurs fewer costs than a laboratory-based pathway. For providers, costs are comparable if not higher, resulting in a negative operating margin.CrossRefPubMedPubMedCentral
30.•
go back to reference Masa JF, Garcia-Ledesma E, Pereira R, et al. Effectiveness of sequential automatic-manual home respiratory polygraphy scoring. Eur Respir J. 2013;41(4):879–87. Sequential (automatic followed by manual) scoring of home sleep apnea tests is a good alternative with lower direct costs for equivalent diagnostic efficacy compared to manually scored home sleep apnea tests or lab PSG.CrossRefPubMed Masa JF, Garcia-Ledesma E, Pereira R, et al. Effectiveness of sequential automatic-manual home respiratory polygraphy scoring. Eur Respir J. 2013;41(4):879–87. Sequential (automatic followed by manual) scoring of home sleep apnea tests is a good alternative with lower direct costs for equivalent diagnostic efficacy compared to manually scored home sleep apnea tests or lab PSG.CrossRefPubMed
31.•
go back to reference Masa JF, Corral J, Pereira R, et al. Effectiveness of three sleep apnea management alternatives. Sleep. 2013;36(12):1799–807. HSAT is a less costly than PSG for equivalent diagnosis and therapeutic decision making capability in patients with suspected obstructive sleep apnea. There is no cost advantage in using HSAT for all patients compared to HSAT for the most symptomatic patients and PSG for the rest.PubMedPubMedCentral Masa JF, Corral J, Pereira R, et al. Effectiveness of three sleep apnea management alternatives. Sleep. 2013;36(12):1799–807. HSAT is a less costly than PSG for equivalent diagnosis and therapeutic decision making capability in patients with suspected obstructive sleep apnea. There is no cost advantage in using HSAT for all patients compared to HSAT for the most symptomatic patients and PSG for the rest.PubMedPubMedCentral
32.•
go back to reference Masa JF, Duran-Cantolla J, Capote F, et al. Effectiveness of home single-channel nasal pressure for sleep apnea diagnosis. Sleep. 2014;37(12):1953–61. HSAT with single-channel nasal pressure sensor is less costly than PSG to achieve same level of diagnostic efficacy. Manual scoring is less costly than automatic scoring to achieve equivalent diagnostic efficacy.PubMedPubMedCentral Masa JF, Duran-Cantolla J, Capote F, et al. Effectiveness of home single-channel nasal pressure for sleep apnea diagnosis. Sleep. 2014;37(12):1953–61. HSAT with single-channel nasal pressure sensor is less costly than PSG to achieve same level of diagnostic efficacy. Manual scoring is less costly than automatic scoring to achieve equivalent diagnostic efficacy.PubMedPubMedCentral
33.•
go back to reference Guerrero A, Embid C, Isetta V, et al. Management of sleep apnea without high pretest probability or with comorbidities by three nights of portable sleep monitoring. Sleep. 2014;37(8):1363–73. Three consecutive nights of HSAT in patients at lower risk of OSA or with comorbid diseases had lower direct costs compared to lab PSG to achieve equivalent diagnostic efficacy. The best agreement of therapeutic decisions was achieved by the sleep medicine specialists (versus non-sleep medicine providers).PubMedPubMedCentral Guerrero A, Embid C, Isetta V, et al. Management of sleep apnea without high pretest probability or with comorbidities by three nights of portable sleep monitoring. Sleep. 2014;37(8):1363–73. Three consecutive nights of HSAT in patients at lower risk of OSA or with comorbid diseases had lower direct costs compared to lab PSG to achieve equivalent diagnostic efficacy. The best agreement of therapeutic decisions was achieved by the sleep medicine specialists (versus non-sleep medicine providers).PubMedPubMedCentral
34.•
go back to reference Safadi A, Etzioni T, Fliss D, et al. The effect of the transition to home monitoring for the diagnosis of OSAS on test availability, waiting time, patients’ satisfaction, and outcome in a large health provider system. Sleep Disord. 2014;2014:418246. There was an increased number of sleep tests, decreased waiting time, similar patient satisfaction, and decreased direct costs for a third party payer after transition from lab-based to home-based testing.PubMedPubMedCentral Safadi A, Etzioni T, Fliss D, et al. The effect of the transition to home monitoring for the diagnosis of OSAS on test availability, waiting time, patients’ satisfaction, and outcome in a large health provider system. Sleep Disord. 2014;2014:418246. There was an increased number of sleep tests, decreased waiting time, similar patient satisfaction, and decreased direct costs for a third party payer after transition from lab-based to home-based testing.PubMedPubMedCentral
35.
go back to reference Andreu AL, Chiner E, Sancho-Chust JN, et al. Effect of an ambulatory diagnostic and treatment programme in patients with sleep apnoea. Eur Respir J. 2012;39(2):305–12.CrossRefPubMed Andreu AL, Chiner E, Sancho-Chust JN, et al. Effect of an ambulatory diagnostic and treatment programme in patients with sleep apnoea. Eur Respir J. 2012;39(2):305–12.CrossRefPubMed
36.
go back to reference Dingli K, Coleman EL, Vennelle M, et al. Evaluation of a portable device for diagnosing the sleep apnoea/hypopnoea syndrome. Eur Respir J. 2003;21(2):253–9.CrossRefPubMed Dingli K, Coleman EL, Vennelle M, et al. Evaluation of a portable device for diagnosing the sleep apnoea/hypopnoea syndrome. Eur Respir J. 2003;21(2):253–9.CrossRefPubMed
Metadata
Title
Home- vs. Laboratory-Based Management Of OSA: An Economic Review
Authors
Ken He
Richard Kim
Vishesh K. Kapur
Publication date
01-06-2016
Publisher
Springer International Publishing
Published in
Current Sleep Medicine Reports / Issue 2/2016
Electronic ISSN: 2198-6401
DOI
https://doi.org/10.1007/s40675-016-0042-3

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