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European Archives of Paediatric Dentistry

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01-12-2013 | Case Report

Case report: Macrodont mandibular second premolars, a hereditary dental anomaly

Authors: A. Kyriazidou, D. Haider, C. Mason, S. Parekh, A. Bloch-Zupan

Published in: European Archives of Paediatric Dentistry | Issue 6/2013

Abstract

Background

Macrodontia or megadontia is a rare dental anomaly that refers to teeth that appear larger than normal. Generalised macrodontia may be associated with certain medical conditions and syndromes. Isolated macrodontia involves single teeth, might be the result of teeth fusion and is mainly seen in the incisor area.

Case reports

This paper describes two unrelated cases presenting with bilateral macrodont second lower premolars and the treatment provided. One case demonstrated the anomaly in both the patient and his father.

Conclusion

This case report suggests for the first time in the literature the genetic aetiology and heritability, as a possible autosomal dominant trait, of this rare dental anomaly.

Bloch-Zupan A, Goodman JR. Otodental syndrome. Orphanet J Rare Dis. 2006;1:5.PubMedCrossRef

Bloch-Zupan A, Sedano H, Scully C. Dento/oro/craniofacial anomalies and genetics. London: Elsevier Inc.; 2012.

Brook AH. A unifying aetiological explanation for anomalies of human tooth number and size. Arch Oral Biol. 1984;29(5):373–8.PubMedCrossRef

Brook AH, Winter GB. Double teeth. A retrospective study of ‘geminated’ and ‘fused’ teeth in children. Br Dent J. 1970;129(3):123–30.PubMedCrossRef

Canoglu E, Canoglu H, Aktas A, Cehreli ZC. Isolated bilateral macrodontia of mandibular second premolars: a case report. Eur J Dent. 2012;6(3):330–4.PubMed

Canut JA, Arias S. Molarization of the lower second premolars. Angle Orthod. 1999;69(4):380–1.PubMed

Chase RH. Unusual macrodontia. Gen Dent. 1994;42(3):216.PubMed

Chate RA. Odontometric evaluation of mandibular premolars with tooth shape deviation: a case–control study. Angle Orthod. 2012;82(5):785–91.PubMedCrossRef

Cortes-Breton Brinkmann J, Barona-Dorado C, Martinez-Rodriguez N, Martin-Ares M, Martinez-Gonzalez JM. Nonsyndromic multiple hyperdontia in a series of 13 patients: epidemiologic and clinical considerations. J Am Dent Assoc. 2012; 143(6):e16–e24.

Dadpe MV, Kale YJ, Patil PS. Molarization of the mandibular second premolars with concurrent dentin dysplasia: a rare case report. IJCD. 2010;1(2):66–9.

Deshingkar SA, Barpande SR, Bhavthankar JD. Congenital hemifacial hyperplasia. Contemp Clin Dent. 2011;2(3):261–4.PubMedCrossRef

Dugmore CR. Bilateral macrodontia of mandibular second premolars: a case report. Int J Paediatr Dent. 2001;11(1):69–73.PubMedCrossRef

Ekman-Westborg B, Julin P. Multiple anomalies in dental morphology: macrodontia, multituberculism, central cusps, and pulp invaginations. Report of a case. Oral Surg Oral Med Oral Pathol. 1974;38(2):217–22.PubMedCrossRef

Fuentes R, Borie E. Bilateral macrodontia of mandibular second premolars: a case report. J Morphol Sci. 2011;28(3):212–5.

Garib DG, Peck S. Extreme variations in the shape of mandibular premolars. Am J Orthod Dentofacial Orthop. 2006;130(3):317–23.PubMedCrossRef

Gregory-Evans CY, Moosajee M, Hodges MD, et al. SNP genome scanning localizes oto-dental syndrome to chromosome 11q13 and microdeletions at this locus implicate FGF3 in dental and inner-ear disease and FADD in ocular coloboma. Hum Mol Genet. 2007;16(20):3482–93.CrossRef

Groper JN. Macrodontia of a single tooth: review of literature and report of case. J Am Dent Assoc. 1987;114(1):69.PubMed

Hennekam RCM, Krantz ID, Allanson JE. Gorlin’s syndromes of the head and neck (Contributors Allanson JE, Bloch-Zupan A, Cohen MM, Cormier-Daire V, Cunniff C, Devriendt K, Geraghty MT, Gorlin RJ, Graham JM, Grunewald S, Hall JG, Hennekam RCM, Krantz ID, Loeys B, MacDonald IM, Mortier G, Moss C, Muenke M, Wilson L) 5th edn. New York: Oxford University Press; 2010.

Holmes J, Tanner MS. Premature eruption and macrodontia associated with insulin resistant diabetes and pineal hyperplasia. Report of two cases. Br Dent J. 1976;141(9):280–4.PubMedCrossRef

Kamal D, Breton P, Bouletreau P. Congenital infiltrating lipomatosis of the face: report of three cases and review of the literature. J Craniomaxillofac Surg. 2010;38(8):610–4.PubMedCrossRef

Lunt DA. ‘Molarization’ of the mandibular second premolars. J Dent. 1976;4(2):83–6.PubMedCrossRef

Nemes JA, Alberth M. The Ekman-Westborg and Julin trait: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102(5):659–62.PubMedCrossRef

Peck S, Peck H, Phaneuf RA. Megadontism anomaly of the mandibular second premolars. Oral Surg Oral Med Oral Pathol. 1983;55(5):543.PubMedCrossRef

Polder BJ, Van’t Hof MA, Van der Linden FP, Kuijpers-Jagtman AM. A meta-analysis of the prevalence of dental agenesis of permanent teeth. Community Dent Oral Epidemiol. 2004;32(3):217–26.PubMedCrossRef

Primack JE. Individual bilateral megadontism: report of case. J Am Dent Assoc. 1967;75(3):655–7.PubMed

Reichart PA, Westergaard J, Jensen KA. Macrodontia of a mandibular premolar. Oral Surg Oral Med Oral Pathol. 1977;44(4):606–9.PubMedCrossRef

Rootkin-Gray VF, Sheehy EC. Macrodontia of a mandibular second premolar: a case report. ASDC J Dent Child. 2001;68(5–6):347–9, 302.

Ruprecht A, Singer DL. Macrodontia of the mandibular left first premolar. Oral Surg Oral Med Oral Pathol. 1979;48(6):573.PubMedCrossRef

Sirmaci A, Spiliopoulos M, Brancati F, et al. Mutations in ANKRD11 Cause KBG syndrome, characterized by intellectual disability, skeletal malformations, and macrodontia. Am J Hum Genet. 2011;89(2):289–94.PubMedCrossRef

Thesleff I. Genetic basis of tooth development and dental defects. Acta Odontol Scand. 2000;58(5):191–4.PubMedCrossRef

Tucker AS, Sharpe PT. Molecular genetics of tooth morphogenesis and patterning: the right shape in the right place. J Dent Res. 1999;78(4):826–34.PubMedCrossRef

Ufomata D. Microdontia of a mandibular second premolar. Oral Surg Oral Med Oral Pathol. 1988;65(5):637–8.PubMedCrossRef

Title: Case report: Macrodont mandibular second premolars, a hereditary dental anomaly
Authors: A. Kyriazidou
D. Haider
C. Mason
S. Parekh
A. Bloch-Zupan
Publication date: 01-12-2013
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Paediatric Dentistry / Issue 6/2013
Print ISSN: 1818-6300
Electronic ISSN: 1996-9805
DOI: https://doi.org/10.1007/s40368-013-0043-6

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Springer Medicine

Case report: Macrodont mandibular second premolars, a hereditary dental anomaly

Abstract

Background

Case reports

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case reports

Conclusion

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