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PharmacoEconomics
Published in: PharmacoEconomics 4/2019

Open Access 01-04-2019 | Autism Spectrum Disorder | Original Research Article

Measuring Health Spillover Effects in Caregivers of Children with Autism Spectrum Disorder: A Comparison of the EQ-5D-3L and SF-6D

Authors: Clare C. Brown, J. Mick Tilford, Nalin Payakachat, D. Keith Williams, Karen A. Kuhlthau, Jeffrey M. Pyne, Renske J. Hoefman, Werner B. F. Brouwer

Published in: PharmacoEconomics | Issue 4/2019

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Abstract

Background and Objective

Healthcare interventions that improve the health of children with autism spectrum disorder (ASD) have the potential to affect the health of caregivers. This study compares the three-level EuroQoL-5 Dimension (EQ-5D-3L) and the Short Form-6 Dimension (SF-6D) in their ability to value such spillover effects in caregivers.

Methods

Clinical data collected from two Autism Treatment Network (ATN) sites was combined with survey data of caregivers of children diagnosed with ASD. Caregivers completed instruments by proxy describing child health and completed the EQ-5D-3L and SF-6D preference-weighted instruments to describe their own health.

Results

There was a strong correlation between the health utility scores of the two preference-weighted instruments (ρ = 0.6172, p < 0.001) measuring caregiver health-related quality of life. There was a similar correlation between both the SF-6D and EQ-5D-3L scores with a previously validated care-related quality of life measure (Care-related Quality of Life instrument [CarerQol-7D]) (ρ = 0.569, p < 0.001 and ρ = 0.541, p < 0.001, respectively). The mean SF-6D scores for caregivers differed significantly in relation to four of the five child health or behavior measures whereas the EQ-5D-3L differed for only two of them.

Conclusions

Health utility values of caregivers for children with ASD vary by the health characteristics of the child, suggesting significant potential for spillover effects. The comparison of the EQ-5D-3L and SF-6D demonstrated that both instruments can be used to estimate spillover effects of interventions to improve child health, but the SF-6D exhibited greater sensitivity to child health among children with ASD.
Appendix
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Metadata
Title
Measuring Health Spillover Effects in Caregivers of Children with Autism Spectrum Disorder: A Comparison of the EQ-5D-3L and SF-6D
Authors
Clare C. Brown
J. Mick Tilford
Nalin Payakachat
D. Keith Williams
Karen A. Kuhlthau
Jeffrey M. Pyne
Renske J. Hoefman
Werner B. F. Brouwer
Publication date
01-04-2019
Publisher
Springer International Publishing
Published in
PharmacoEconomics / Issue 4/2019
Print ISSN: 1170-7690
Electronic ISSN: 1179-2027
DOI
https://doi.org/10.1007/s40273-019-00789-2

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