Skip to main content
Top
Published in: PharmacoEconomics 2/2016

Open Access 01-02-2016 | Original Research Article

Calculating Total Health Service Utilisation and Costs from Routinely Collected Electronic Health Records Using the Example of Patients with Irritable Bowel Syndrome Before and After Their First Gastroenterology Appointment

Authors: Caroline Canavan, Joe West, Timothy Card

Published in: PharmacoEconomics | Issue 2/2016

Login to get access

Abstract

Introduction

Health economic models are increasingly important in funding decisions but most are based on data, which may therefore not represent the general population. We sought to establish the potential of real-world data available within the Clinical Practice Research Datalink (CPRD) and linked Hospital Episode Statistics (HES) to determine comprehensive healthcare utilisation and costs as input variables for economic modelling.

Methods

A cohort of patients with irritable bowel syndrome (IBS) who first saw a gastroenterologist in 2008 or 2009, and with 3 years of data before and after their appointment, was created in the CPRD. Primary care, outpatient, inpatient, prescription and colonoscopy data were extracted from the linked CPRD and HES. The appropriate cost to the NHS was attached to each event. Total and stratified annual healthcare utilisation rates and costs were calculated before and after the gastroenterology appointment with distribution parameters. Absolute differences were calculated with 95 % confidence intervals.

Results

Total annual healthcare costs over 3 years increase by £935 (95 % CI £928–941) following a gastroenterology appointment for IBS. We derived utilisation and cost data with parameter distributions stratified by demographics and time. Women, older patients, smokers and patients with greater comorbidity utilised more healthcare resources, which generated higher costs.

Conclusions

These linked datasets provide comprehensive primary and secondary care data for large numbers of patients, which allows stratification of outcomes. It is possible to derive input parameters appropriate for economic models and their distributions directly from the population of interest.
Literature
3.
go back to reference Asaria M, Walker S, Sculpher MJ, et al. Challenges of conducting economic evaluations using linked electronic health records—CPRD and HES in the United Kingdom. Value Health. 2013;16:A580.CrossRef Asaria M, Walker S, Sculpher MJ, et al. Challenges of conducting economic evaluations using linked electronic health records—CPRD and HES in the United Kingdom. Value Health. 2013;16:A580.CrossRef
4.
go back to reference Clinical Practice Research Datalink. CPRD Gold Flat files release notes. London. Clinical Practice Research Datalink. CPRD Gold Flat files release notes. London.
5.
go back to reference Puri S. Hospital Episode Statistics (HES) data and GOLD documentation. Puri S. Hospital Episode Statistics (HES) data and GOLD documentation.
6.
go back to reference Curtis L. Unit costs of health and social care 2011. Canterbury: University of Kent; 2011. Curtis L. Unit costs of health and social care 2011. Canterbury: University of Kent; 2011.
9.
go back to reference National Institute for Health and Care Excellence. Irritable bowel syndrome in adults: diagnosis and management of irritable bowel syndrome in primary care. NICE Clinical Guideline, No. 61. London: NICE; 2008. National Institute for Health and Care Excellence. Irritable bowel syndrome in adults: diagnosis and management of irritable bowel syndrome in primary care. NICE Clinical Guideline, No. 61. London: NICE; 2008.
10.
go back to reference Thompson WG, Longstreth GF, Drossman DA, et al. Functional bowel disorders and functional abdominal pain. Gut. 1999;45(Suppl 2):II43–7. Thompson WG, Longstreth GF, Drossman DA, et al. Functional bowel disorders and functional abdominal pain. Gut. 1999;45(Suppl 2):II43–7.
11.
go back to reference Longstreth GF, Thompson WG, Chey WD, et al. Functional bowel disorders. Gastroenterology. 2006;130:1480–91.CrossRefPubMed Longstreth GF, Thompson WG, Chey WD, et al. Functional bowel disorders. Gastroenterology. 2006;130:1480–91.CrossRefPubMed
12.
go back to reference National Institute for Health and Care Excellence. Irritable bowel syndrome in adults: diagnosis and management of irritable bowel syndrome in primary care. NICE Clinical Guideline, No. 61. Manchester: NICE; 2015. Available at: https://www.nice.org.uk/guidance/cg61. Accessed 29 Jun 2015. National Institute for Health and Care Excellence. Irritable bowel syndrome in adults: diagnosis and management of irritable bowel syndrome in primary care. NICE Clinical Guideline, No. 61. Manchester: NICE; 2015. Available at: https://​www.​nice.​org.​uk/​guidance/​cg61. Accessed 29 Jun 2015.
13.
go back to reference Thompson WG, Heaton KW, Smyth GT, et al. Irritable bowel syndrome in general practice: prevalence, characteristics, and referral. Gut. 2000;46:78–82.PubMedCentralCrossRefPubMed Thompson WG, Heaton KW, Smyth GT, et al. Irritable bowel syndrome in general practice: prevalence, characteristics, and referral. Gut. 2000;46:78–82.PubMedCentralCrossRefPubMed
14.
go back to reference Lacy BE, Rosemore J, Robertson D, et al. Physicians’ attitudes and practices in the evaluation and treatment of irritable bowel syndrome. Scand J Gastroenterol. 2006;41:892–902.CrossRefPubMed Lacy BE, Rosemore J, Robertson D, et al. Physicians’ attitudes and practices in the evaluation and treatment of irritable bowel syndrome. Scand J Gastroenterol. 2006;41:892–902.CrossRefPubMed
15.
go back to reference Wells NE, Hahn BA, Whorwell PJ. Clinical economics review: irritable bowel syndrome. Aliment Pharmacol Ther. 1997;11:1019–30.CrossRefPubMed Wells NE, Hahn BA, Whorwell PJ. Clinical economics review: irritable bowel syndrome. Aliment Pharmacol Ther. 1997;11:1019–30.CrossRefPubMed
16.
go back to reference Smith GD, Steinke DT, Kinnear M, et al. A comparison of irritable bowel syndrome patients managed in primary and secondary care: the Episode IBS study. Br J Gen Pract. 2004;54:503–7.PubMedCentralPubMed Smith GD, Steinke DT, Kinnear M, et al. A comparison of irritable bowel syndrome patients managed in primary and secondary care: the Episode IBS study. Br J Gen Pract. 2004;54:503–7.PubMedCentralPubMed
17.
go back to reference Ford AC, Bercik P, Morgan DG, et al. Characteristics of functional bowel disorder patients: a cross-sectional survey using the Rome III criteria. Aliment Pharmacol Ther. 2014;39:312–21.CrossRefPubMed Ford AC, Bercik P, Morgan DG, et al. Characteristics of functional bowel disorder patients: a cross-sectional survey using the Rome III criteria. Aliment Pharmacol Ther. 2014;39:312–21.CrossRefPubMed
19.
go back to reference Department of Health. NHS reference costs: financial year 2011 to 2012. London: Department of Health; 2012. Department of Health. NHS reference costs: financial year 2011 to 2012. London: Department of Health; 2012.
20.
go back to reference Canavan C, Card T, West J. The incidence of other gastroenterological disease following diagnosis of irritable bowel syndrome in the UK: a cohort study. PLoS One. 2014;9:e106478.PubMedCentralCrossRefPubMed Canavan C, Card T, West J. The incidence of other gastroenterological disease following diagnosis of irritable bowel syndrome in the UK: a cohort study. PLoS One. 2014;9:e106478.PubMedCentralCrossRefPubMed
22.
go back to reference Record C, Day C. Britain’s alcohol market: how minimum alcohol prices could stop moderate drinkers subsidising those drinking at hazardous and harmful levels. Clin Med. 2009;9:421–5.CrossRef Record C, Day C. Britain’s alcohol market: how minimum alcohol prices could stop moderate drinkers subsidising those drinking at hazardous and harmful levels. Clin Med. 2009;9:421–5.CrossRef
24.
go back to reference Quan H, Li B, Couris CM, et al. Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol. 2011;173:676–82.CrossRefPubMed Quan H, Li B, Couris CM, et al. Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol. 2011;173:676–82.CrossRefPubMed
25.
go back to reference Stata statistical software. College Station (TX): StataCorp LP. Stata statistical software. College Station (TX): StataCorp LP.
27.
go back to reference Williams T, van Staa T, Puri S, et al. Recent advances in the utility and use of the General Practice Research Database as an example of a UK Primary Care Data resource. Ther Adv Drug Saf. 2012;3:89–99.PubMedCentralCrossRefPubMed Williams T, van Staa T, Puri S, et al. Recent advances in the utility and use of the General Practice Research Database as an example of a UK Primary Care Data resource. Ther Adv Drug Saf. 2012;3:89–99.PubMedCentralCrossRefPubMed
28.
go back to reference Chen Y-C, Wu J-C, Haschler I, et al. Academic impact of a public electronic health database: bibliometric analysis of studies using the general practice research database. PLoS One. 2011;6:e21404.PubMedCentralCrossRefPubMed Chen Y-C, Wu J-C, Haschler I, et al. Academic impact of a public electronic health database: bibliometric analysis of studies using the general practice research database. PLoS One. 2011;6:e21404.PubMedCentralCrossRefPubMed
29.
go back to reference Dolan P, Torgerson DJ. The cost of treating osteoporotic fractures in the United Kingdom female population. Osteoporos Int. 1998;8:611–7.CrossRefPubMed Dolan P, Torgerson DJ. The cost of treating osteoporotic fractures in the United Kingdom female population. Osteoporos Int. 1998;8:611–7.CrossRefPubMed
30.
go back to reference Denis P, Lafuma A, Berdeaux G. Costs and persistence of alpha-2 adrenergic agonists versus carbonic anhydrase inhibitors, both associated with prostaglandin analogues, for glaucoma as recorded by The United Kingdom General Practitioner Research Database. Clin Ophthalmol. 2008;2:321–9.PubMedCentralPubMed Denis P, Lafuma A, Berdeaux G. Costs and persistence of alpha-2 adrenergic agonists versus carbonic anhydrase inhibitors, both associated with prostaglandin analogues, for glaucoma as recorded by The United Kingdom General Practitioner Research Database. Clin Ophthalmol. 2008;2:321–9.PubMedCentralPubMed
31.
go back to reference Lafuma A, Laurendeau C, Berdeaux G. Costs and persistence of brimonidine versus brinzolamide in everyday glaucoma care: an analysis conducted on the UK General Practitioner Research Database. J Med Econ. 2008;11:485–97.CrossRefPubMed Lafuma A, Laurendeau C, Berdeaux G. Costs and persistence of brimonidine versus brinzolamide in everyday glaucoma care: an analysis conducted on the UK General Practitioner Research Database. J Med Econ. 2008;11:485–97.CrossRefPubMed
32.
go back to reference Deschaseaux-Voinet C, Lafuma A, Berdeaux G. Cost and effectiveness of brinzolamide versus dorzolamide in current practice: an analysis based on the UK-GPRD database. J Med Econ. 2003;6(1–4):69–78.CrossRef Deschaseaux-Voinet C, Lafuma A, Berdeaux G. Cost and effectiveness of brinzolamide versus dorzolamide in current practice: an analysis based on the UK-GPRD database. J Med Econ. 2003;6(1–4):69–78.CrossRef
33.
go back to reference Lafuma A, Berdeaux G. Costs and effectiveness of travoprost versus a dorzolamide + timolol fixed combination in first-line treatment of glaucoma: analysis conducted on the United Kingdom General Practitioner Research Database. Curr Med Res Opin. 2007;23:3009–16.CrossRefPubMed Lafuma A, Berdeaux G. Costs and effectiveness of travoprost versus a dorzolamide + timolol fixed combination in first-line treatment of glaucoma: analysis conducted on the United Kingdom General Practitioner Research Database. Curr Med Res Opin. 2007;23:3009–16.CrossRefPubMed
34.
go back to reference Gulliford MC, Charlton J, Bhattarai N, et al. Impact and cost-effectiveness of a universal strategy to promote physical activity in primary care: population-based cohort study and Markov model. Eur J Health Econ. 2014;15:341–51.PubMedCentralCrossRefPubMed Gulliford MC, Charlton J, Bhattarai N, et al. Impact and cost-effectiveness of a universal strategy to promote physical activity in primary care: population-based cohort study and Markov model. Eur J Health Econ. 2014;15:341–51.PubMedCentralCrossRefPubMed
35.
go back to reference Hong J, Reed C, Novick D, et al. Costs associated with treatment of chronic low back pain: an analysis of the UK General Practice Research Database. Spine (Phila Pa 1976). 2013;38:75–82.CrossRef Hong J, Reed C, Novick D, et al. Costs associated with treatment of chronic low back pain: an analysis of the UK General Practice Research Database. Spine (Phila Pa 1976). 2013;38:75–82.CrossRef
36.
go back to reference Reed C, Novick D, Lenox-smith A, et al. Health care costs before and after diagnosis of depression in patients with unexplained pain : a retrospective cohort study using the United Kingdom General Practice Research Database. Clinicoecon Outcomes Res. 2013;5:37–47.PubMedCentralCrossRefPubMed Reed C, Novick D, Lenox-smith A, et al. Health care costs before and after diagnosis of depression in patients with unexplained pain : a retrospective cohort study using the United Kingdom General Practice Research Database. Clinicoecon Outcomes Res. 2013;5:37–47.PubMedCentralCrossRefPubMed
37.
go back to reference Shi N, Cao Z, Durden E, et al. Healthcare utilization among patients with depression before and after initiating duloxetine in the United Kingdom. J Med Econ. 2012;15:672–80.CrossRefPubMed Shi N, Cao Z, Durden E, et al. Healthcare utilization among patients with depression before and after initiating duloxetine in the United Kingdom. J Med Econ. 2012;15:672–80.CrossRefPubMed
38.
go back to reference Boggon R, Lip GYH, Gallagher AM, et al. Resource utilization and outcomes in patients with atrial fibrillation: a case control study. Appl Health Econ Health Policy. 2012;10:249–59.CrossRefPubMed Boggon R, Lip GYH, Gallagher AM, et al. Resource utilization and outcomes in patients with atrial fibrillation: a case control study. Appl Health Econ Health Policy. 2012;10:249–59.CrossRefPubMed
39.
go back to reference Violato M, Gray A, Papanicolas I, et al. Resource use and costs associated with coeliac disease before and after diagnosis in 3,646 cases: results of a UK primary care database analysis. PLoS One. 2012;7:e41308.PubMedCentralCrossRefPubMed Violato M, Gray A, Papanicolas I, et al. Resource use and costs associated with coeliac disease before and after diagnosis in 3,646 cases: results of a UK primary care database analysis. PLoS One. 2012;7:e41308.PubMedCentralCrossRefPubMed
40.
go back to reference Abdul Sultan A, Tata LJ, Grainge MJ, et al. The incidence of first venous thromboembolism in and around pregnancy using linked primary and secondary care data: a population based cohort study from England and comparative meta-analysis. PLoS One. 2013;8:e70310. Abdul Sultan A, Tata LJ, Grainge MJ, et al. The incidence of first venous thromboembolism in and around pregnancy using linked primary and secondary care data: a population based cohort study from England and comparative meta-analysis. PLoS One. 2013;8:e70310.
41.
go back to reference Brilleman SL, Purdy S, Salisbury C, et al. Implications of comorbidity for primary care costs in the UK: a retrospective observational study. Br J Gen Pract. 2013;63:e274–82.PubMedCentralCrossRefPubMed Brilleman SL, Purdy S, Salisbury C, et al. Implications of comorbidity for primary care costs in the UK: a retrospective observational study. Br J Gen Pract. 2013;63:e274–82.PubMedCentralCrossRefPubMed
42.
go back to reference Basu A. Economics of individualization in comparative effectiveness research and a basis for a patient-centered health care. J Health Econ. 2011;30:549–59.PubMedCentralCrossRefPubMed Basu A. Economics of individualization in comparative effectiveness research and a basis for a patient-centered health care. J Health Econ. 2011;30:549–59.PubMedCentralCrossRefPubMed
43.
go back to reference Groot Koerkamp B, Weinstein MC, Stijnen T, et al. Uncertainty and patient heterogeneity in medical decision models. Med Decis Making. 2010;30:194–205.CrossRefPubMed Groot Koerkamp B, Weinstein MC, Stijnen T, et al. Uncertainty and patient heterogeneity in medical decision models. Med Decis Making. 2010;30:194–205.CrossRefPubMed
44.
go back to reference Philips Z, Bojke L, Sculpher M, et al. Good practice guidelines for decision-analytic modelling in health technology assessment. Pharmacoeconomics. 2006;24:355–71.CrossRefPubMed Philips Z, Bojke L, Sculpher M, et al. Good practice guidelines for decision-analytic modelling in health technology assessment. Pharmacoeconomics. 2006;24:355–71.CrossRefPubMed
45.
go back to reference Caro JJ, Briggs AH, Siebert U. Modeling good research practices—overview: a report of the ISPOR-SMDM Modeling Good Research Practices Task Force-1. Value Health. 2012;15(6):796–803.CrossRefPubMed Caro JJ, Briggs AH, Siebert U. Modeling good research practices—overview: a report of the ISPOR-SMDM Modeling Good Research Practices Task Force-1. Value Health. 2012;15(6):796–803.CrossRefPubMed
46.
go back to reference Bijkerk CJ, Muris JWM, Knottnerus JA, et al. Randomized patients in IBS research had different disease characteristics compared to eligible and recruited patients. J Clin Epidemiol. 2008;61:1176–81.CrossRefPubMed Bijkerk CJ, Muris JWM, Knottnerus JA, et al. Randomized patients in IBS research had different disease characteristics compared to eligible and recruited patients. J Clin Epidemiol. 2008;61:1176–81.CrossRefPubMed
47.
go back to reference Van Staa T-P, Leufkens HG, Zhang B, et al. A comparison of cost effectiveness using data from randomized trials or actual clinical practice: selective COX-2 inhibitors as an example. PLoS Med. 2009;6:e1000194.PubMedCentralCrossRefPubMed Van Staa T-P, Leufkens HG, Zhang B, et al. A comparison of cost effectiveness using data from randomized trials or actual clinical practice: selective COX-2 inhibitors as an example. PLoS Med. 2009;6:e1000194.PubMedCentralCrossRefPubMed
48.
go back to reference Herrett E, Thomas SL, Schoonen WM, et al. Validation and validity of diagnoses in the General Practice Research Database: a systematic review. Br J Clin Pharmacol. 2010;69:4–14.PubMedCentralCrossRefPubMed Herrett E, Thomas SL, Schoonen WM, et al. Validation and validity of diagnoses in the General Practice Research Database: a systematic review. Br J Clin Pharmacol. 2010;69:4–14.PubMedCentralCrossRefPubMed
49.
go back to reference Khan NF, Harrison SE, Rose PW. Validity of diagnostic coding within the General Practice Research Database : a systematic review. Br J Gen Pract. 2010;60(572):e128–36.PubMedCentralCrossRefPubMed Khan NF, Harrison SE, Rose PW. Validity of diagnostic coding within the General Practice Research Database : a systematic review. Br J Gen Pract. 2010;60(572):e128–36.PubMedCentralCrossRefPubMed
50.
go back to reference Ruigómez A, García Rodríguez LA, Johansson S, et al. Is hormone replacement therapy associated with an increased risk of irritable bowel syndrome? Maturitas. 2003;44:133–40.CrossRefPubMed Ruigómez A, García Rodríguez LA, Johansson S, et al. Is hormone replacement therapy associated with an increased risk of irritable bowel syndrome? Maturitas. 2003;44:133–40.CrossRefPubMed
51.
go back to reference Carey IM, Dewilde S, Harris T, et al. Spurious trends in coronary heart disease incidence: unintended consequences of the new GP contract? Br J Gen Pract. 2007;57:486–9.PubMedCentralPubMed Carey IM, Dewilde S, Harris T, et al. Spurious trends in coronary heart disease incidence: unintended consequences of the new GP contract? Br J Gen Pract. 2007;57:486–9.PubMedCentralPubMed
52.
go back to reference Carey IM, Nightingale CM, DeWilde S, et al. Blood pressure recording bias during a period when the Quality and Outcomes Framework was introduced. J Hum Hypertens. 2009;23:764–70.CrossRefPubMed Carey IM, Nightingale CM, DeWilde S, et al. Blood pressure recording bias during a period when the Quality and Outcomes Framework was introduced. J Hum Hypertens. 2009;23:764–70.CrossRefPubMed
53.
go back to reference Griffiths RI, Gleeson ML, Danese MD, et al. Inverse probability weighted least squares regression in the analysis of time-censored cost data: an evaluation of the approach using SEER-Medicare. Value Health. 2012;15:656–63.CrossRefPubMed Griffiths RI, Gleeson ML, Danese MD, et al. Inverse probability weighted least squares regression in the analysis of time-censored cost data: an evaluation of the approach using SEER-Medicare. Value Health. 2012;15:656–63.CrossRefPubMed
55.
go back to reference Windmeijer F, Kontodimas S, Knapp M, et al. Methodological approach for assessing the cost-effectiveness of treatments using longitudinal observational data: the SOHO study. Int J Technol Assess Health Care. 2006;22:460–8.CrossRefPubMed Windmeijer F, Kontodimas S, Knapp M, et al. Methodological approach for assessing the cost-effectiveness of treatments using longitudinal observational data: the SOHO study. Int J Technol Assess Health Care. 2006;22:460–8.CrossRefPubMed
56.
go back to reference Van Staa T-P, Dyson L, McCann G, et al. The opportunities and challenges of pragmatic point-of-care randomised trials using routinely collected electronic records: evaluations of two exemplar trials. Health Technol Assess. 2014;18:1–146.PubMed Van Staa T-P, Dyson L, McCann G, et al. The opportunities and challenges of pragmatic point-of-care randomised trials using routinely collected electronic records: evaluations of two exemplar trials. Health Technol Assess. 2014;18:1–146.PubMed
57.
go back to reference Van Staa T-P, Klungel O, Smeeth L. Use of electronic healthcare records in large-scale simple randomized trials at the point of care for the documentation of value-based medicine. J Intern Med. 2014;275:562–9.CrossRefPubMed Van Staa T-P, Klungel O, Smeeth L. Use of electronic healthcare records in large-scale simple randomized trials at the point of care for the documentation of value-based medicine. J Intern Med. 2014;275:562–9.CrossRefPubMed
58.
go back to reference Brennan A, Chick SE, Davies R. A taxonomy of model structures for economic evaluation of health technologies. Health Econ. 2006;15(12):1295–310.CrossRefPubMed Brennan A, Chick SE, Davies R. A taxonomy of model structures for economic evaluation of health technologies. Health Econ. 2006;15(12):1295–310.CrossRefPubMed
59.
go back to reference Kopec JA, Sayre EC, Flanagan WM, et al. Development of a population-based microsimulation model of osteoarthritis in Canada. Osteoarthritis Cartilage. 2010;18(3):303–11.CrossRefPubMed Kopec JA, Sayre EC, Flanagan WM, et al. Development of a population-based microsimulation model of osteoarthritis in Canada. Osteoarthritis Cartilage. 2010;18(3):303–11.CrossRefPubMed
60.
go back to reference Briggs AH, Weinstein MC, Fenwick EAL, et al. Model parameter estimation and uncertainty: a report of the ISPOR-SMDM Modeling Good Research Practices Task Force-6. Value Health. 2012;15:835–42.CrossRefPubMed Briggs AH, Weinstein MC, Fenwick EAL, et al. Model parameter estimation and uncertainty: a report of the ISPOR-SMDM Modeling Good Research Practices Task Force-6. Value Health. 2012;15:835–42.CrossRefPubMed
61.
go back to reference King F, Willford J, Nelson M. The power of real world evidence: filling the gap between basic research and decision making. Access Point. 2013;4:16–21. King F, Willford J, Nelson M. The power of real world evidence: filling the gap between basic research and decision making. Access Point. 2013;4:16–21.
Metadata
Title
Calculating Total Health Service Utilisation and Costs from Routinely Collected Electronic Health Records Using the Example of Patients with Irritable Bowel Syndrome Before and After Their First Gastroenterology Appointment
Authors
Caroline Canavan
Joe West
Timothy Card
Publication date
01-02-2016
Publisher
Springer International Publishing
Published in
PharmacoEconomics / Issue 2/2016
Print ISSN: 1170-7690
Electronic ISSN: 1179-2027
DOI
https://doi.org/10.1007/s40273-015-0339-y

Other articles of this Issue 2/2016

PharmacoEconomics 2/2016 Go to the issue