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Drugs in R&D
Published in: Drugs in R&D 1/2015

Open Access 01-03-2015 | Current Opinion

Pharmaceutical, Biological, and Clinical Properties of Botulinum Neurotoxin Type A Products

Author: Jürgen Frevert

Published in: Drugs in R&D | Issue 1/2015

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Abstract

Botulinum neurotoxin injections are a valuable treatment modality for many therapeutic indications and have revolutionized the field of aesthetic medicine so that they are the leading cosmetic procedure performed worldwide. Studies show that onabotulinumtoxinA, abobotulinumtoxinA, and incobotulinumtoxinA are comparable in terms of clinical efficacy. Differences between the products relate to the botulinum neurotoxin complexes, specific biological potency, and their immunogenicity. Protein complex size and molecular weight have no effect on biological activity, stability, distribution, or side effect profile. Complexing proteins and inactive toxin (toxoid) content increase the risk of neutralizing antibody formation, which can cause secondary treatment failure, particularly in chronic disorders that require frequent injections and long-term treatment. These attributes could lead to differences in therapeutic outcomes, and, given the widespread aesthetic use of these three neurotoxin products, physicians should be aware of how they differ to ensure their safe and effective use.
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Metadata
Title
Pharmaceutical, Biological, and Clinical Properties of Botulinum Neurotoxin Type A Products
Author
Jürgen Frevert
Publication date
01-03-2015
Publisher
Springer International Publishing
Published in
Drugs in R&D / Issue 1/2015
Print ISSN: 1174-5886
Electronic ISSN: 1179-6901
DOI
https://doi.org/10.1007/s40268-014-0077-1

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