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01-06-2019 | Cushing's Syndrome | Review Article

Medical Management of Cushing’s Syndrome: Current and Emerging Treatments

Authors: José Miguel Hinojosa-Amaya, Daniel Cuevas-Ramos, Maria Fleseriu

Published in: Drugs | Issue 9/2019

Abstract

Endogenous Cushing’s syndrome is a chronic disease associated with increased morbidity and mortality if not appropriately treated. Recurrence and/or persistence of hypercortisolemia after surgical treatment, especially for Cushing’s disease, are high, and long-term medical treatment is used to decrease cortisol levels and risk of metabolic comorbidities. Medical treatment is also often required while waiting for radiation effects to take place. In some cases, severe or life-threatening hypercortisolism must be urgently and medically treated, via intravenous medications or with combination therapy, before patients can undergo surgery. In the last decade, medical treatment has progressed from a few steroidogenesis inhibitors to three novel drug groups: new inhibitors for steroidogenic enzymes with possibly fewer side effects, pituitary-directed drugs that aim to inhibit the pathophysiological pathways of Cushing’s disease, and glucocorticoid receptor antagonists that block cortisol’s action. Understanding the pathophysiology of Cushing’s syndrome has also led to the identification of potential targets that may decrease adrenocorticotrophic hormone and/or cortisol excess, and/or decrease tumor cell proliferation, and induce senescence or apoptosis. We provide here a review of current and near-future medical options to treat Cushing’s syndrome, and discuss updates on clinical trials and the efficacy and safety of novel or in-development drugs, as well as future potential targets.

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Title: Medical Management of Cushing’s Syndrome: Current and Emerging Treatments
Authors: José Miguel Hinojosa-Amaya
Daniel Cuevas-Ramos
Maria Fleseriu
Publication date: 01-06-2019
Publisher: Springer International Publishing
Keywords: Cushing's Syndrome
Ketoconazole
Cabergoline
Published in: Drugs / Issue 9/2019
Print ISSN: 0012-6667
Electronic ISSN: 1179-1950
DOI: https://doi.org/10.1007/s40265-019-01128-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Medical Management of Cushing’s Syndrome: Current and Emerging Treatments

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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