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Published in: Drugs 12/2018

01-08-2018 | Leading Article

Adult-Onset Still’s Disease: Molecular Pathophysiology and Therapeutic Advances

Authors: Paolo Sfriso, Sara Bindoli, Paola Galozzi

Published in: Drugs | Issue 12/2018

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Abstract

Adult-onset Still’s disease (AOSD) is a rare inflammatory disorder of unknown etiology generally characterized by persistent high spiking fever, evanescent rash, and polyarthritis. The pathogenesis of AOSD is only partially known. The pivotal role of macrophage cell activation, which leads to T-helper 1 (Th1) cell cytokine activation, is now well-established in AOSD. Moreover, pro-inflammatory cytokines such as interleukin (IL)-1, -6, and -18 seem to play a key role in this disorder, giving rise to the development of new targeted therapies. For years, treatment of AOSD has been largely empirical, using nonsteroidal anti-inflammatory drugs, corticosteroids, and disease-modifying antirheumatic drugs. Patients with steroid- and methotrexate-refractory AOSD can now benefit from efficient and well-tolerated biologic agents such as IL-1, IL-6, and tumor necrosis factor-α antagonists.
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Metadata
Title
Adult-Onset Still’s Disease: Molecular Pathophysiology and Therapeutic Advances
Authors
Paolo Sfriso
Sara Bindoli
Paola Galozzi
Publication date
01-08-2018
Publisher
Springer International Publishing
Published in
Drugs / Issue 12/2018
Print ISSN: 0012-6667
Electronic ISSN: 1179-1950
DOI
https://doi.org/10.1007/s40265-018-0956-9

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