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CNS Drugs
Published in: CNS Drugs 11/2016

Open Access 01-11-2016 | Leading Article

May the Force Be With You: The Light and Dark Sides of the Microbiota–Gut–Brain Axis in Neuropsychiatry

Authors: Eoin Sherwin, Kiran V. Sandhu, Timothy G. Dinan, John F. Cryan

Published in: CNS Drugs | Issue 11/2016

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Abstract

The role of the gut microbiota in health and disease is becoming increasingly recognized. The microbiota–gut–brain axis is a bi-directional pathway between the brain and the gastrointestinal system. The bacterial commensals in our gut can signal to the brain through a variety of mechanisms, which are slowly being resolved. These include the vagus nerve, immune mediators and microbial metabolites, which influence central processes such as neurotransmission and behaviour. Dysregulation in the composition of the gut microbiota has been identified in several neuropsychiatric disorders, such as autism, schizophrenia and depression. Moreover, preclinical studies suggest that they may be the driving force behind the behavioural abnormalities observed in these conditions. Understanding how bacterial commensals are involved in regulating brain function may lead to novel strategies for development of microbiota-based therapies for these neuropsychiatric disorders.
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Metadata
Title
May the Force Be With You: The Light and Dark Sides of the Microbiota–Gut–Brain Axis in Neuropsychiatry
Authors
Eoin Sherwin
Kiran V. Sandhu
Timothy G. Dinan
John F. Cryan
Publication date
01-11-2016
Publisher
Springer International Publishing
Published in
CNS Drugs / Issue 11/2016
Print ISSN: 1172-7047
Electronic ISSN: 1179-1934
DOI
https://doi.org/10.1007/s40263-016-0370-3

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