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01-12-2020 | Pharmacodynamics | Letter to the Editor

Comment on “Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab”

Authors: Jialing Liu, Aliza Anwar Memon, Lingna Lyu, Andrew Siedlecki

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Dear Editor, …

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Wijnsma KL, Ter Heine R, Moes DJAR, et al. Pharmacology, pharmacokinetics and pharmacodynamics of eculizumab, and possibilities for an individualized approach to eculizumab. Clin Pharmacokinet. 2019;58(7):859–74. https://doi.org/10.1007/s40262-019-00742-8.CrossRefPubMedPubMedCentral

Soliris^® (eculizumab) US Prescribing Information. October 2017. Reference ID 4171013. Available online from https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/125166s422lbl.pdf. Accessed 21 Oct 2020.

Duval A, Olagne J, Cognard N, et al. Pregnancy in a kidney transplant woman under treatment with eculizumab for atypical hemolytic uremic syndrome: is it safe? Kidney Int Rep. 2019;4(5):733–9. https://doi.org/10.1016/j.ekir.2018.12.014.CrossRefPubMedPubMedCentral

Sharma R, Keyzner A, Liu J, Bradley T, Allen SL. Successful pregnancy outcome in paroxysmal nocturnal hemoglobinuria (PNH) following escalated eculizumab dosing to control breakthrough hemolysis. Leuk Res Rep. 2015;4(1):36–8. https://doi.org/10.1016/j.lrr.2015.05.001.CrossRefPubMedPubMedCentral

Ricklin D, Barratt-Due A, Mollnes TE. Complement in clinical medicine: clinical trials, case reports and therapy monitoring. Mol Immunol. 2017;89:10–21. https://doi.org/10.1016/j.molimm.2017.05.013.CrossRefPubMed

Kelly RJ, Höchsmann B, Szer J, et al. Eculizumab in pregnant patients with paroxysmal nocturnal hemoglobinuria. N Engl J Med. 2015;373(11):1032–9. https://doi.org/10.1056/NEJMoa1502950.CrossRefPubMed

Title: Comment on “Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab”
Authors: Jialing Liu
Aliza Anwar Memon
Lingna Lyu
Andrew Siedlecki
Publication date: 01-12-2020
Publisher: Springer International Publishing
Keywords: Pharmacodynamics
Thrombotic Microangiopathy
Paroxysmal Nocturnal Hemoglobinuria
Published in: Clinical Pharmacokinetics / Issue 12/2020
Print ISSN: 0312-5963
Electronic ISSN: 1179-1926
DOI: https://doi.org/10.1007/s40262-020-00950-7