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Clinical Pharmacokinetics
Published in: Clinical Pharmacokinetics 5/2014

01-05-2014 | Review Article

Viral Hepatitis C Therapy: Pharmacokinetic and Pharmacodynamic Considerations

Authors: Clara T. M. M. de Kanter, Joost P. H. Drenth, Joop E. Arends, Henk W. Reesink, Marc van der Valk, Robert J. de Knegt, David M. Burger

Published in: Clinical Pharmacokinetics | Issue 5/2014

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Abstract

Chronic hepatitis C is a global health problem. To prevent or reduce complications, the hepatitis C virus (HCV) infection needs to be eradicated. There have been several developments in treating these patients since the discovery of the virus. As of 1 January 2014, the drugs that are approved for treatment of chronic HCV infection are peginterferon-α, ribavirin, boceprevir, telaprevir, simeprevir and sofosbuvir. In this review we provide an overview of the clinical pharmacokinetic characteristics of these agents by describing their absorption, distribution, metabolism and excretion. In the pharmacodynamic part we summarize what is known about the relationships between the pharmacokinetics of each drug and efficacy or toxicity. We briefly discuss the pharmacokinetics and pharmacodynamics of chronic hepatitis C treatment in special patient populations, such as patients with liver cirrhosis, renal insufficiency or HCV/HIV coinfection, and children. With this knowledge, physicians, pharmacists, nurse practitioners, etc. should be educated to safely and effectively treat HCV-infected patients.
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Metadata
Title
Viral Hepatitis C Therapy: Pharmacokinetic and Pharmacodynamic Considerations
Authors
Clara T. M. M. de Kanter
Joost P. H. Drenth
Joop E. Arends
Henk W. Reesink
Marc van der Valk
Robert J. de Knegt
David M. Burger
Publication date
01-05-2014
Publisher
Springer International Publishing
Published in
Clinical Pharmacokinetics / Issue 5/2014
Print ISSN: 0312-5963
Electronic ISSN: 1179-1926
DOI
https://doi.org/10.1007/s40262-014-0142-5

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