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BioDrugs
Published in: BioDrugs 1/2014

01-02-2014 | Leading Article

Treg Vaccination in Autoimmune Type 1 Diabetes

Authors: Isabelle Serr, Benno Weigmann, Randi Kristina Franke, Carolin Daniel

Published in: BioDrugs | Issue 1/2014

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Abstract

Foxp3+ regulatory T (Treg) cells are critical contributors to the establishment and maintenance of immunological self-tolerance. Autoimmune type 1 diabetes (T1D) is characterized by the loss of self-tolerance to the insulin-producing β cells in the pancreas and the destruction of β cells, resulting in the development of chronic hyperglycemia at diagnosis. The application of strong-agonistic T-cell receptor ligands provided under subimmunogenic conditions functions as a critical means for the efficient de novo conversion of naive CD4+ T cells into Foxp3+ Treg cells. The specific induction of Treg cells upon supply of strong-agonistic variants of certain self-antigens could therefore function as a critical instrument in order to achieve safe and specific prevention of autoimmunity such as T1D via the restoration of self-tolerance. Such immunotherapeutic strategies are being developed, and in the case of T1D aim to restrict autoimmunity and β-cell destruction. In this review, we discuss the requirements and opportunities for Treg-based tolerance approaches with the goal of interfering with autoimmune T1D.
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Metadata
Title
Treg Vaccination in Autoimmune Type 1 Diabetes
Authors
Isabelle Serr
Benno Weigmann
Randi Kristina Franke
Carolin Daniel
Publication date
01-02-2014
Publisher
Springer International Publishing
Published in
BioDrugs / Issue 1/2014
Print ISSN: 1173-8804
Electronic ISSN: 1179-190X
DOI
https://doi.org/10.1007/s40259-013-0060-3

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