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BioDrugs
Published in: BioDrugs 5/2013

01-10-2013 | Leading Article

The Th17 Pathway as a Therapeutic Target in Rheumatoid Arthritis and Other Autoimmune and Inflammatory Disorders

Authors: Debbie M. Roeleveld, Annemarie E. M. van Nieuwenhuijze, Wim B. van den Berg, Marije I. Koenders

Published in: BioDrugs | Issue 5/2013

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Abstract

Production of the pro-inflammatory cytokine interleukin (IL)-17 by Th17 cells and other cells of the immune system protects the host against bacterial and fungal infections, but also promotes the development of rheumatoid arthritis (RA) and other autoimmune and inflammatory disorders. Several biologicals targeting IL-17, the IL-17 receptor, or IL-17-related pathways are being tested in clinical trials, and might ultimately lead to better treatment for patients suffering from various IL-17-mediated disorders. In this review, we provide a clear overview of current knowledge on Th17 cell regulation and the main Th17 effector cytokines in relation to IL-17-mediated conditions, as well as on recent IL-17-related drug developments. We demonstrate that targeting the Th17 pathway is a promising treatment for rheumatoid arthritis and various other autoimmune and inflammatory diseases. However, improvements in technical developments assisting in the identification of patients suffering from IL-17-driven disease are needed to enable the application of tailor-made, personalized medicine.
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Metadata
Title
The Th17 Pathway as a Therapeutic Target in Rheumatoid Arthritis and Other Autoimmune and Inflammatory Disorders
Authors
Debbie M. Roeleveld
Annemarie E. M. van Nieuwenhuijze
Wim B. van den Berg
Marije I. Koenders
Publication date
01-10-2013
Publisher
Springer International Publishing
Published in
BioDrugs / Issue 5/2013
Print ISSN: 1173-8804
Electronic ISSN: 1179-190X
DOI
https://doi.org/10.1007/s40259-013-0035-4

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