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Published in: Applied Health Economics and Health Policy 1/2015

01-02-2015 | Original Research Article

Healthcare Costs Associated with Antiretroviral Adherence Among Medicaid Patients

Authors: Zachary Pruitt, John Robst, Barbara Langland-Orban, Robert G. Brooks

Published in: Applied Health Economics and Health Policy | Issue 1/2015

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Abstract

Background

The relationship of antiretroviral therapy (ART) adherence to total healthcare expenditures for Medicaid-insured people living with HIV or AIDS (PLWHA) is not well understood, especially among asymptomatic HIV-positive patients.

Objective

This study examined Medicaid-insured HIV-positive and AIDS-diagnosed patient groups to determine the association of ART adherence to mean monthly total healthcare expenditures in the 24-month measurement period, controlling for demographic, geographic, insurance, and clinical factors. The present study extends the existing literature by analyzing the relationship of ART adherence to total healthcare costs for asymptomatic HIV-positive patients separately from those patients with AIDS-defining conditions.

Methods

This retrospective study utilized claims data from Florida Medicaid claims from July 2006 through June 2011. All patients (n = 502) were HIV-positive, aged 18–64 years, non-pregnant, and ART naïve for at least 12 months prior to the measurement period. Each patient was categorized, based on medication possession ratios, as adherent (≥90 %) or non-adherent (<90 %), and were divided into two groups: HIV positive (n = 232) and AIDS diagnosed (n = 270). Generalized linear models predicted the mean monthly total expenditures for the non-adherence group versus the adherence group.

Results

For the HIV-positive group, the adjusted mean monthly expenditures for the non-adherent group were US$1,291; the adherent group adjusted mean monthly expenditures were US$1,926. The HIV-positive non-adherent group adjusted mean monthly expenditures were significantly less than the adherent group (−40 %, p < 0.001). However, for the AIDS-diagnosed group, there was not a statistically significant association of ART adherence to total healthcare expenditures (p = 0.29).

Conclusion

The results show that the relationship of ART adherence to healthcare costs is more complex than previously reported.
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Literature
1.
go back to reference Dieffenbach CW, Fauci AS. Thirty years of HIV and AIDS: future challenges and opportunities. Ann Intern Med. 2011;154:766.PubMedCrossRef Dieffenbach CW, Fauci AS. Thirty years of HIV and AIDS: future challenges and opportunities. Ann Intern Med. 2011;154:766.PubMedCrossRef
2.
go back to reference Kitahata MM, Gange SJ, Abraham AG, Merriman B, Saag MS, Justice AC, Moore RD. Effect of early versus deferred antiretroviral therapy for HIV on survival. N Engl J Med. 2009;18:1815–26.CrossRef Kitahata MM, Gange SJ, Abraham AG, Merriman B, Saag MS, Justice AC, Moore RD. Effect of early versus deferred antiretroviral therapy for HIV on survival. N Engl J Med. 2009;18:1815–26.CrossRef
3.
go back to reference Reynolds SJ, Makumbi F, Nakigozi G, Kagaayi J, Gray RH, Wawer M, Quinn TC, Serwadda D. HIV-1 transmission among HIV-1 discordant couples before and after the introduction of antiretroviral therapy. AIDS. 2011;25:473–7.PubMedCentralPubMedCrossRef Reynolds SJ, Makumbi F, Nakigozi G, Kagaayi J, Gray RH, Wawer M, Quinn TC, Serwadda D. HIV-1 transmission among HIV-1 discordant couples before and after the introduction of antiretroviral therapy. AIDS. 2011;25:473–7.PubMedCentralPubMedCrossRef
4.
go back to reference Bozzette SA, Joyce G, McCaffrey DF, et al. Expenditures for the care of HIV-infected patients in the era of highly active antiretroviral therapy. N Engl J Med. 2001;344:817–23.PubMedCrossRef Bozzette SA, Joyce G, McCaffrey DF, et al. Expenditures for the care of HIV-infected patients in the era of highly active antiretroviral therapy. N Engl J Med. 2001;344:817–23.PubMedCrossRef
5.
go back to reference Nachega JB, Leisegang R, Bishai D, Nguyen H, Hislop M, Cleary S, Regensberg L, Maartens G. Association of antiretroviral therapy adherence and health care costs. Ann Intern Med. 2010;152:18–25.PubMedCrossRef Nachega JB, Leisegang R, Bishai D, Nguyen H, Hislop M, Cleary S, Regensberg L, Maartens G. Association of antiretroviral therapy adherence and health care costs. Ann Intern Med. 2010;152:18–25.PubMedCrossRef
6.
go back to reference Gardner EM, Maravi ME, Rietmeijer C, Davidson AJ, Burman WJ. The association of adherence to antiretroviral therapy with healthcare utilization and costs for medical care. Appl Health Econ Health Policy. 2008;6:145–55.PubMedCentralPubMedCrossRef Gardner EM, Maravi ME, Rietmeijer C, Davidson AJ, Burman WJ. The association of adherence to antiretroviral therapy with healthcare utilization and costs for medical care. Appl Health Econ Health Policy. 2008;6:145–55.PubMedCentralPubMedCrossRef
7.
go back to reference Acurcio FA, Puig-Junoy J, Bonolo PF, Braga Ceccato MG, Guimaraes MD. Análisis coste-efectividad de la adhesión inicial a la terapia antirretroviral entre individuos infectados por el VIH en Belo Horizonte, Brasil. Rev Espa Nola Salud Pública. 2006;80:41–54.CrossRef Acurcio FA, Puig-Junoy J, Bonolo PF, Braga Ceccato MG, Guimaraes MD. Análisis coste-efectividad de la adhesión inicial a la terapia antirretroviral entre individuos infectados por el VIH en Belo Horizonte, Brasil. Rev Espa Nola Salud Pública. 2006;80:41–54.CrossRef
8.
go back to reference US Department of Health and Human Services. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Bethesda: US Department of Health and Human Services; 2011. pp. 1–166. US Department of Health and Human Services. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Bethesda: US Department of Health and Human Services; 2011. pp. 1–166.
9.
go back to reference Thompson MA, Aberg JA, Cahn P, Montaner JS, Rizzardini G, Telenti A, Schooley RT. Antiretroviral treatment of adult HIV infection 2010 recommendations of the International AIDS Society—USA Panel. JAMA. 2010;304:321–33.PubMedCrossRef Thompson MA, Aberg JA, Cahn P, Montaner JS, Rizzardini G, Telenti A, Schooley RT. Antiretroviral treatment of adult HIV infection 2010 recommendations of the International AIDS Society—USA Panel. JAMA. 2010;304:321–33.PubMedCrossRef
10.
go back to reference McMahon D, DiNubile M, Meibohm A, Marino D, Robertson M. Efficacy, safety, and tolerability of long-term combination antiretroviral therapy in asymptomatic treatment-naïve adults with early HIV infection. HIV Clin Trials. 2007;8:269–81.PubMedCrossRef McMahon D, DiNubile M, Meibohm A, Marino D, Robertson M. Efficacy, safety, and tolerability of long-term combination antiretroviral therapy in asymptomatic treatment-naïve adults with early HIV infection. HIV Clin Trials. 2007;8:269–81.PubMedCrossRef
13.
go back to reference Florida Statute. Reimbursement of Medicaid providers. Social and Economic Assistance 409.912(39)(a) (2008). Florida Statute. Reimbursement of Medicaid providers. Social and Economic Assistance 409.912(39)(a) (2008).
14.
go back to reference Public Health Service Act. § 340B, 42 U.S.C. (2013). Public Health Service Act. § 340B, 42 U.S.C. (2013).
15.
go back to reference Smith SR, Rublein JC, Marcus C, Brock TP, Chesney MA. A medication self-management program to improve adherence to HIV therapy regimens. Patient Educ Couns. 2003;50:187–99.PubMedCrossRef Smith SR, Rublein JC, Marcus C, Brock TP, Chesney MA. A medication self-management program to improve adherence to HIV therapy regimens. Patient Educ Couns. 2003;50:187–99.PubMedCrossRef
16.
go back to reference Nachega JB, Hislop M, Dowdy DW, Lo M, Omer SB, Regensberg L, Chaisson RE, Maartens G. Adherence to highly active antiretroviral therapy assessed by pharmacy claims predicts survival in HIV-infected South African adults. J Acquir Immun Defic Syndr. 2006;43:78–84.CrossRef Nachega JB, Hislop M, Dowdy DW, Lo M, Omer SB, Regensberg L, Chaisson RE, Maartens G. Adherence to highly active antiretroviral therapy assessed by pharmacy claims predicts survival in HIV-infected South African adults. J Acquir Immun Defic Syndr. 2006;43:78–84.CrossRef
17.
go back to reference Mills EJ, Nachega JB, Buchan I, et al. Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis. JAMA. 2006;296:679–90.PubMedCrossRef Mills EJ, Nachega JB, Buchan I, et al. Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis. JAMA. 2006;296:679–90.PubMedCrossRef
18.
go back to reference Steiner JF, Prochazka AV. The assessment of refill compliance using pharmacy records: methods, validity, and applications. J Clin Epidemiol. 1997;50:105–16.PubMedCrossRef Steiner JF, Prochazka AV. The assessment of refill compliance using pharmacy records: methods, validity, and applications. J Clin Epidemiol. 1997;50:105–16.PubMedCrossRef
19.
go back to reference Maggiolo F, Ravasio L, Ripamonti D, Gregis G, Quinzan G, Arici C, Airoldi M, Suter F. Similar adherence rates favor different virologic outcomes for patients treated with nonnucleoside analogues or protease inhibitors. Clin Infect Dis. 2005;40:158–63.PubMedCrossRef Maggiolo F, Ravasio L, Ripamonti D, Gregis G, Quinzan G, Arici C, Airoldi M, Suter F. Similar adherence rates favor different virologic outcomes for patients treated with nonnucleoside analogues or protease inhibitors. Clin Infect Dis. 2005;40:158–63.PubMedCrossRef
20.
go back to reference U.S. Census Bureau. U.S. Census Bureau, 2005–2009 American Community Survey. Washington, DC: U.S. Census Bureau; 2013. U.S. Census Bureau. U.S. Census Bureau, 2005–2009 American Community Survey. Washington, DC: U.S. Census Bureau; 2013.
22.
go back to reference Fakhraei SH, Kaelin JJ, Conviser R. Comorbidity-based payment methodology for Medicaid enrollees with HIV/AIDS. Health Care Financ Rev. 2001;23:53–68.PubMedCentralPubMed Fakhraei SH, Kaelin JJ, Conviser R. Comorbidity-based payment methodology for Medicaid enrollees with HIV/AIDS. Health Care Financ Rev. 2001;23:53–68.PubMedCentralPubMed
23.
go back to reference Manning WG, Basu A, Mullahy J. Generalized modeling approaches to risk adjustment of skewed outcomes data. J Health Econ. 2005;24(3):465–88. Manning WG, Basu A, Mullahy J. Generalized modeling approaches to risk adjustment of skewed outcomes data. J Health Econ. 2005;24(3):465–88.
24.
go back to reference Manning WG, Mullahy J. Estimating log models: to transform or not to transform? J Health Econ. 2001;20:461–94.PubMedCrossRef Manning WG, Mullahy J. Estimating log models: to transform or not to transform? J Health Econ. 2001;20:461–94.PubMedCrossRef
25.
go back to reference Short PF, Graefe DR, Schoen C. Churn, churn, churn: how instability of health insurance shapes America’s uninsured problem. New York: Commonwealth Fund; 2003. Short PF, Graefe DR, Schoen C. Churn, churn, churn: how instability of health insurance shapes America’s uninsured problem. New York: Commonwealth Fund; 2003.
26.
go back to reference Johnson MO, Dilworth SE, Taylor JM, Neilands TB. Improving coping skills for self-management of treatment side effects can reduce antiretroviral medication nonadherence among people living with HIV. Ann Behav Med. 2010;41:83–91.PubMedCentralCrossRef Johnson MO, Dilworth SE, Taylor JM, Neilands TB. Improving coping skills for self-management of treatment side effects can reduce antiretroviral medication nonadherence among people living with HIV. Ann Behav Med. 2010;41:83–91.PubMedCentralCrossRef
27.
go back to reference Ammassari A, Murri A, Pezzotti P, Trotta MP, Ravasio L, De Longis P, Antinori A. Self-reported symptoms and medication side effects influence adherence to highly active antiretroviral therapy in persons with HIV infection. J Acquir Immune Defic Syndr. 2001;28:445–9.PubMedCrossRef Ammassari A, Murri A, Pezzotti P, Trotta MP, Ravasio L, De Longis P, Antinori A. Self-reported symptoms and medication side effects influence adherence to highly active antiretroviral therapy in persons with HIV infection. J Acquir Immune Defic Syndr. 2001;28:445–9.PubMedCrossRef
28.
go back to reference Wohl DA, McComsey G, Tebas P, Brown TT, Glesby MJ, Reeds D, Wanke C. Current concepts in the diagnosis and management of metabolic complications of HIV infection and its therapy. Clin Infect Dis. 2006;43:645–53.PubMedCrossRef Wohl DA, McComsey G, Tebas P, Brown TT, Glesby MJ, Reeds D, Wanke C. Current concepts in the diagnosis and management of metabolic complications of HIV infection and its therapy. Clin Infect Dis. 2006;43:645–53.PubMedCrossRef
29.
go back to reference Rudorf DC. Adverse effects associated with antiretroviral therapy and potential management strategies. J Pharm Pract. 2005;18:258–77.CrossRef Rudorf DC. Adverse effects associated with antiretroviral therapy and potential management strategies. J Pharm Pract. 2005;18:258–77.CrossRef
30.
go back to reference Hall AG, Harman JS, Zhang J. Lapses in Medicaid coverage: impact on cost and utilization among individuals with diabetes enrolled in Medicaid. Med Care. 2008;46:1219–25.PubMedCrossRef Hall AG, Harman JS, Zhang J. Lapses in Medicaid coverage: impact on cost and utilization among individuals with diabetes enrolled in Medicaid. Med Care. 2008;46:1219–25.PubMedCrossRef
31.
go back to reference Harman JS, Hall AG, Zhang J. Changes in health care use and costs after a break in Medicaid coverage among persons with depression. Psychiatr Serv. 2007;58:49–54.PubMedCrossRef Harman JS, Hall AG, Zhang J. Changes in health care use and costs after a break in Medicaid coverage among persons with depression. Psychiatr Serv. 2007;58:49–54.PubMedCrossRef
Metadata
Title
Healthcare Costs Associated with Antiretroviral Adherence Among Medicaid Patients
Authors
Zachary Pruitt
John Robst
Barbara Langland-Orban
Robert G. Brooks
Publication date
01-02-2015
Publisher
Springer International Publishing
Published in
Applied Health Economics and Health Policy / Issue 1/2015
Print ISSN: 1175-5652
Electronic ISSN: 1179-1896
DOI
https://doi.org/10.1007/s40258-014-0138-1

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