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American Journal of Clinical Dermatology
Published in: American Journal of Clinical Dermatology 5/2023

03-07-2023 | Melanoma | Review Article

Diagnosis and Management of Dermatologic Adverse Events from Systemic Melanoma Therapies

Authors: Christopher J. Fay, Samantha Jakuboski, Beth Mclellan, Blair S. Allais, Yevgeniy Semenov, Cecilia A. Larocca, Nicole R. LeBoeuf

Published in: American Journal of Clinical Dermatology | Issue 5/2023

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Abstract

The advent of protein kinase inhibitors and immunotherapy has profoundly improved the management of advanced melanoma. However, with these therapeutic advancements also come drug-related toxicities that have the potential to affect various organ systems. We review dermatologic adverse events from targeted (including BRAF and MEK inhibitor-related) and less commonly used melanoma treatments, with a focus on diagnosis and management. As immunotherapy-related toxicities have been extensively reviewed, herein, we discuss injectable talimogene laherparepvec and touch on recent breakthroughs in the immunotherapy space. Dermatologic adverse events may severely impact quality of life and are associated with response and survival. It is therefore essential that clinicians are aware of their diverse presentations and management strategies.
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Metadata
Title
Diagnosis and Management of Dermatologic Adverse Events from Systemic Melanoma Therapies
Authors
Christopher J. Fay
Samantha Jakuboski
Beth Mclellan
Blair S. Allais
Yevgeniy Semenov
Cecilia A. Larocca
Nicole R. LeBoeuf
Publication date
03-07-2023
Publisher
Springer International Publishing
Keywords
Melanoma
Melanoma
Published in
American Journal of Clinical Dermatology / Issue 5/2023
Print ISSN: 1175-0561
Electronic ISSN: 1179-1888
DOI
https://doi.org/10.1007/s40257-023-00790-8

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