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American Journal of Clinical Dermatology
Published in: American Journal of Clinical Dermatology 6/2018

01-12-2018 | Review Article

Major Comorbidities of Atopic Dermatitis: Beyond Allergic Disorders

Authors: Amy Paller, Jennifer C. Jaworski, Eric L. Simpson, Mark Boguniewicz, John J. Russell, Julie K. Block, Susan Tofte, Jeffrey D. Dunn, Steven R. Feldman, Adele R. Clark, Gene Schwartz, Lawrence F. Eichenfield, MD

Published in: American Journal of Clinical Dermatology | Issue 6/2018

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Abstract

The consequences of atopic dermatitis reach beyond the skin and past childhood. Patients with atopic dermatitis are at risk of developing allergic comorbidities, but less is known about the associations between atopic dermatitis and non-allergic conditions. Understanding these non-allergic comorbidities has the potential to improve patient outcomes and to help mitigate the cost and burdens associated with these conditions. Atopic dermatitis is associated with cutaneous bacterial infections, more severe forms/courses of cutaneous viral infections, and extra-cutaneous infections. Atopic dermatitis is also associated with several mental health comorbidities particularly attention-deficit hyperactivity disorder, anxiety, and depression. Data are largely inconsistent for specific cancers, but atopic dermatitis appears to protect against malignancy overall; severe long-term atopic dermatitis is associated with adult lymphomas. Atopic dermatitis may also be associated with obesity, cardiovascular disease, and autoimmune disease, particularly alopecia areata and gastrointestinal immune-mediated disorders. Although the causative mechanisms underlying these associations are poorly understood, treating physicians should be aware of associations in seeking to alleviate the burden for patients with atopic dermatitis.
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Metadata
Title
Major Comorbidities of Atopic Dermatitis: Beyond Allergic Disorders
Authors
Amy Paller
Jennifer C. Jaworski
Eric L. Simpson
Mark Boguniewicz
John J. Russell
Julie K. Block
Susan Tofte
Jeffrey D. Dunn
Steven R. Feldman
Adele R. Clark
Gene Schwartz
Lawrence F. Eichenfield, MD
Publication date
01-12-2018
Publisher
Springer International Publishing
Published in
American Journal of Clinical Dermatology / Issue 6/2018
Print ISSN: 1175-0561
Electronic ISSN: 1179-1888
DOI
https://doi.org/10.1007/s40257-018-0383-4

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