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Neurology and Therapy
Published in: Neurology and Therapy 1/2015

Open Access 01-06-2015 | Commentary

On Gelsemium and Complementary and Alternative Medicine (CAM) in Anxiety and Experimental Neurology

Author: Salvatore Chirumbolo

Published in: Neurology and Therapy | Issue 1/2015

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Abstract

A recent discussion expanded the debate about the experimental research on Gelsemium in anxiety. Herbal medicine is widely used in anxiety and mood disorders, often with contradictory evidence, although some authors are yet prompted to promote their full introduction in pharmacology as a promising therapy. Complementary and alternative medicine (CAM) in anxiety is particularly appreciated by individual healthcare, but deserves further investigation, as many critical issues have been recently raised. Comments about the ability of negligible doses of Gelsemium hydroalcoholic extracts to affect gene expression were recently reported.
Literature
1.
Faustino TT, Almeida RB, Andreatini R. Medicinal plants for the treatment of generalized anxiety disorder: a review of controlled clinical studies. Rev Bras Psiquiatr. 2010;32(4):429–36.PubMedCrossRef
2.
Mills PJ, Farag NH, Newton RP, Parry BL. Effects of a traditional herbal supplement on anxiety in patients with generalized anxiety disorder. J Clin Psychopharmacol. 2002;22(4):443–4.PubMedCrossRef
3.
4.
Bazzan AJ, Zabrecky G, Monti DA, Newberg AB. Current evidence regarding the management of mood and anxiety disorders using complementary and alternative medicine. Expert Rev Neurother. 2014;14(4):411–23.PubMedCrossRef
5.
Ravindran AV, da Silva TL. Complementary and alternative therapies as add-on to pharmacotherapy for mood and anxiety disorders: a systematic review. J Affect Disord. 2013;150(3):707–19.PubMedCrossRef
6.
Moss AS, Monti DA, Amsterdam JD, Newberg AB. Complementary and alternative medicine therapies in mood disorders. Expert Rev Neurother. 2011;11(7):1049–56.PubMedCrossRef
7.
Paris A, Schmidlin S, Mouret S, Hodaj E, Marijnen P, Boujedaini N, Polosan M, Cracowski JL. Effect of Gelsemium 5CH and 15CH on anticipatory anxiety: a phase III, single-centre, randomized, placebo-controlled study. Fundam Clin Pharmacol. 2012;26(6):751–60.PubMedCrossRef
8.
Chirumbolo S. Plant-derived extracts in the neuroscience of anxiety on animal models: biases and comments. Int J Neurosci. 2012;122(4):177–88.PubMedCrossRef
9.
Chirumbolo S. Gelsemine and Gelsemium sempervirens L. extracts in animal behavioral test: comments and related biases. Front Neurol. 2011;2:31.
10.
Bellavite P. Gelsemium sempervirens and animal behavioral models. Front Neurol. 2011;12(2):56.
11.
Jin GL, Su YP, Liu M, Xu Y, Yang J, Liao KJ, Yu CX. Medicinal plants of the genus Gelsemium (Gelsemiaceae, Gentianales)—a review of their phytochemistry, pharmacology, toxicology and traditional use. J Ethnopharmacol. 2014;152(1):33–52.PubMedCrossRef
12.
Liu M, Huang HH, Yang J, Su YP, Lin HW, Lin LQ, Liao WJ, Yu CX. The active alkaloids of Gelsemium elegans Benth. are potent anxiolytics. Psychopharmacology (Berl). 2013;225(4):839–51.
13.
Meyer L, Boujedaini N, Patte-Mensah C, Mensah-Nyagan AG. Pharmacological effect of gelsemine on anxiety-like behavior in rat. Behav Brain Res. 2013;253:90–4.PubMedCrossRef
14.
Dutt V, Dhar VJ, Sharma A. Antianxiety activity of Gelsemium sempervirens. Pharm Biol. 2010;48(10):1091–6.PubMedCrossRef
15.
Magnani P, Conforti A, Zanolin E, Marzotto M, Bellavite P. Dose-effect study of Gelsemium sempervirens in high dilutions on anxiety-related responses in mice. Psychopharmacology. 2010;210(4):533–45.PubMedCentralPubMedCrossRef
16.
Bellavite P, Magnani P, Marzotto M, Conforti A. Assays of homeopathic remedies in rodent behavioural and psychopathological models. Homeopathy. 2009;98(4):208–27.PubMedCrossRef
17.
Sukul NC, Bala SK, Bhattacharyya B. Prolonged cataleptogenic effects of potentized homoeopathic drugs. Psychopharmacology. 1986;89(3):338–9.PubMedCrossRef
18.
Chirumbolo S. High diluted molecules and gene expression. Front Pharmacol. 2014;14(5):183.
19.
Marzotto M, Olioso D, Bellavite P. Gene expression and highly diluted molecules. Front Pharmacol. 2014;12(5):237.
20.
Marzotto M, Olioso D, Brizzi M, Tononi P, Cristofoletti M, Bellavite P. Extreme sensitivity of gene expression in human SH-SY5Y neurocytes to ultra-low doses of Gelsemium sempervirens. BMC Complement Altern Med. 2014;19(14):104.CrossRef
21.
Olioso D, Marzotto M, Moratti E, Brizzi M, Bellavite P. Effects of Gelsemium sempervirens L. on pathway-focused gene expression profiling in neuronal cells. J Ethnopharmacol. 2014;153(2):535–9.PubMedCrossRef
22.
Zhang JY, Gong N, Huang JL, Guo LC, Wang YX. Gelsemine, a principal alkaloid from Gelsemium sempervirens Ait., exhibits potent and specific antinociception in chronic pain by acting at spinal α3 glycine receptors. Pain. 2013;154(11):2452–62.PubMedCrossRef
23.
Venard C, Boujedaini N, Belon P, Mensah-Nyagan AG, Patte-Mensah C. Regulation of neurosteroid allopregnanolone biosynthesis in the rat spinal cord by glycine and the alkaloidal analogs strychnine and gelsemine. Neuroscience. 2008;153(1):154–61.PubMedCrossRef
24.
Shen H, Mohammad A, Ramroop J, Smith SS. A stress steroid triggers anxiety via increased expression of α4βδ GABAA receptors in methamphetamine dependence. Neuroscience. 2013;254:452–75.PubMedCrossRef
25.
Smith SS, Ruderman Y, Frye C, Homanics G, Yuan M. Steroid withdrawal in the mouse results in anxiogenic effects of 3alpha,5beta-THP: a possible model of premenstrual dysphoric disorder. Psychopharmacology. 2006;186(3):323–33.PubMedCentralPubMedCrossRef
26.
Xu Y, Qiu HQ, Liu H, Liu M, Huang ZY, Yang J, Su YP, Yu CX. Effects of koumine, an alkaloid of Gelsemium elegans Benth., on inflammatory and neuropathic pain models and possible mechanism with allopregnanolone. Pharmacol Biochem Behav. 2012;101(3):504–14.PubMedCrossRef
27.
Liu M, Shen J, Liu H, Xu Y, Su YP, Yang J, Yu CX. Gelsenicine from Gelsemium elegans attenuates neuropathic and inflammatory pain in mice. Biol Pharm Bull. 2011;34(12):1877–80.PubMedCrossRef
28.
Komatsu H, Furuya Y, Sawada K, Asada T. Involvement of the strychnine-sensitive glycine receptor in the anxiolytic effects of GlyT1 inhibitors on maternal separation-induced ultrasonic vocalization in rat pups. Eur J Pharmacol. 2014 (in press). doi:10.​1016/​j.​ejphar.​2014.​11.​024.
29.
Girish C, Raj V, Arya J, Balakrishnan S. Involvement of the GABAergic system in the anxiolytic-like effect of the flavonoid ellagic acid in mice. Eur J Pharmacol. 2013;710(1–3):49–58.PubMedCrossRef
30.
Avolio E, Biasone A, Mele M, Alò R. Distinct anxiogenic/anxiolytic effects exerted by the hamster lateral amygdalar nucleus injected with ORX-A or ORX-B in the presence of a GABAergic agonist. NeuroReport. 2014;25(12):932–7.PubMedCrossRef
31.
Kalueff AV, Nguyen M. Testing anxiolytic drugs in the C57BL/6 J mouse strain. J Pharmacol Toxicol Methods. 2014;69(2):205–7.
32.
Cervo L, Torri V. Comment on: “Dose-effect study of Gelsemium sempervirens in high dilutions on anxiety-related responses in mice” (Magnani P, Conforti A, Zanolin E, Marzotto M and Bellavite P, Psychopharmacology, 2010). Psychopharmacology (Berl). 2012; 220(2):439–40 (author reply 441–2).
33.
Sun M, Hou X, Gao H, Guo J, Xiao K. Two new koumine-type indole alkaloids from Gelsemium elegans Benth. Molecules. 2013;18(2):1819–25.PubMedCrossRef
34.
Zhang L, Du L, Lv WW, Zhao QC, Hua W, An Y, Guo T, Wu LJ. Four new koumine metabolites in rat liver microsomes. J Asian Nat Prod Res. 2013;15(1):46–52.PubMedCrossRef
35.
Paul P, Qiao J, Kim KW, Romain C, Lee S, Volny N, Mobley B, Correa H, Chung DH. Targeting gastrin-releasing peptide suppresses neuroblastoma progression via upregulation of PTEN signaling. PLoS ONE. 2013;8(9):e72570.PubMedCentralPubMedCrossRef
36.
37.
Glazner GW, Cannon RL, Kulkosky PJ. Effect of bombesin on behaviors associated with ethanol satiation and blood ethanol levels. Alcohol. 1988;5(4):325–30.
38.
Luttinger D, Frye GD, Nemeroff CB, Prange AJ Jr. The effects of neurotensin, beta-endorphin, and bombesin on ethanol-induced behaviors in mice. Psychopharmacology. 1983;79(4):357–63.PubMedCrossRef
39.
40.
Blaw ME, Adkisson MA, Levin D, Garriott JC, Tindall RS. Poisoning with Carolina jessamine (Gelsemium sempervirens [L.] Ait.). J Pediatr. 1979;94(6):998–1001.PubMed
Metadata
Title
On Gelsemium and Complementary and Alternative Medicine (CAM) in Anxiety and Experimental Neurology
Author
Salvatore Chirumbolo
Publication date
01-06-2015
Publisher
Springer Healthcare
Published in
Neurology and Therapy / Issue 1/2015
Print ISSN: 2193-8253
Electronic ISSN: 2193-6536
DOI
https://doi.org/10.1007/s40120-014-0025-6

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