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Acta Neurologica Belgica

Published in:

19-03-2023 | Stroke | Original article

Morphological predictors of neurological deterioration in patients with acute isolated pontine infarct

Authors: Chen Wang, Jianling Ji, Wanting Wang, Yujie Wang

Published in: Acta Neurologica Belgica | Issue 4/2023

Abstract

Objective

To investigate morphological predictors of neurological deterioration (ND) in patients with acute isolated pontine infarct.

Methods

Acute isolated pontine infarct patients within 7 days after onset of stroke symptoms were included retrospectively and classified into ND and non-ND groups. Morphological phenotypes (paramedian pontine infarct [PPI], atypical PPI, small deep infarct, and other types), topographical location, and lesion size were evaluated on axial diffusion-weighted imaging.

Results

There were 210 eligible patients, of whom 62 patients had ND (29.5%). The proportion of PPI was significantly higher in ND than that in non-ND (62.9% vs 39.6%). ND occurred more frequently in PPI patients than non-PPI patients (39.8% vs 20.5%). PPI located more frequently in lower pontine (20.4% vs 8.0%) and less in upper pontine (17.3% vs 30.4%, P = 0.028), and had larger ventro-dorsal length (13.8 ± 3.8 vs 9.9 ± 3.1) and width (8.3 ± 2.3 vs 6.2 ± 1.8) than non-PPI patients. The morphological phenotype of PPI was an independent risk factor for ND (OR 4.81, 95%CI 1.54–15.07, P = 0.007) in patients with isolated pontine infarct. The ventro-dorsal length of pontine infarct lesion was associated with ND (OR 1.18, 95%CI 1.01, 1.37, P = 0.034) in PPI patients.

Conclusions

The morphological phenotype of PPI was a potential predictor for ND in patients with acute isolated pontine infarct. The ventro-dorsal length of pontine infarct lesion was possibly associated with ND in PPI patients.

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Title: Morphological predictors of neurological deterioration in patients with acute isolated pontine infarct
Authors: Chen Wang
Jianling Ji
Wanting Wang
Yujie Wang
Publication date: 19-03-2023
Publisher: Springer International Publishing
Keyword: Stroke
Published in: Acta Neurologica Belgica / Issue 4/2023
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-023-02234-w

2024 ASCO Annual Meeting

Springer Medicine

Morphological predictors of neurological deterioration in patients with acute isolated pontine infarct

Abstract

Objective

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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