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01-03-2017 | Original Article

Do evoked potentials contribute to the functional follow-up and clinical prognosis of multiple sclerosis?

Authors: Xavier Giffroy, Nathalie Maes, Adelin Albert, Pierre Maquet, Jean-Michel Crielaard, Dominique Dive

Published in: Acta Neurologica Belgica | Issue 1/2017

Abstract

The clinical variability and complexity of multiple sclerosis (MS) challenges the individual clinical course prognostication. This study aimed to find out whether multimodal evoked potentials (EP) correlate with the motor components of multiple sclerosis functional composite (MSFCm) and predict clinically relevant motor functional deterioration. One hundred MS patients were assessed at baseline (T ₀) and about 7.5 years later (T ₁), with visual, somatosensory and motor EP and rated on the Expanded Disability Status Scale (EDSS) and the MSFCm, including the 9 Hole Peg Test and the Timed 25 Foot Walk (T25FW). The Spearman correlation coefficient (r _S) was used to evaluate the cross-sectional and longitudinal relationship between EP Z scores and clinical findings. The predictive value of baseline electrophysiological data for clinical worsening (EDSS, 9-HPT, T25FW, MSFCm) during follow-up was assessed by logistic regression analysis. Unlike longitudinal correlations, cross-sectional correlations between EP Z scores and clinical outcomes were all significant and ranged between 0.22 and 0.67 (p < 0.05). The global EP Z score was systematically predictive of EDSS and MSFCm worsening over time (all p < 0.05). EP latency was a better predictor than amplitude, although weaker than latency and amplitude aggregation in the global EP Z score. The study demonstrates that EP numerical scores can be used for motor function monitoring and outcome prediction in patients with MS.

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Title: Do evoked potentials contribute to the functional follow-up and clinical prognosis of multiple sclerosis?
Authors: Xavier Giffroy
Nathalie Maes
Adelin Albert
Pierre Maquet
Jean-Michel Crielaard
Dominique Dive
Publication date: 01-03-2017
Publisher: Springer International Publishing
Published in: Acta Neurologica Belgica / Issue 1/2017
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-016-0650-1

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Do evoked potentials contribute to the functional follow-up and clinical prognosis of multiple sclerosis?

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