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Published in: Current Geriatrics Reports 4/2014

01-12-2014 | Cardiovascular Disease in the Elderly (DE Forman, Section Editor)

The Effects of Aerobic Exercise on Cognitive and Neural Decline in Aging and Cardiovascular Disease

Authors: Scott M. Hayes, Michael L. Alosco, Daniel E. Forman

Published in: Current Geriatrics Reports | Issue 4/2014

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Abstract

Aging is characterized by a decline in cognitive functions, particularly in the domains of executive function, processing speed and episodic memory. These age-related declines are exacerbated by cardiovascular disease (CVD) and cardiovascular risk factors (hypertension, diabetes, obesity, elevated total cholesterol). Structural and functional alterations in brain regions, including the fronto-parietal and medial temporal lobes, have been linked to age- and CVD-related cognitive decline. Multiple recent studies indicate that aerobic exercise programs may slow the progression of age-related neural changes and reduce the risk for mild cognitive impairment as well as dementia. We review age- and CVD-related decline in cognition and the underlying changes in brain morphology and function, and then clarify the impact of aerobic exercise on moderating these patterns.
Literature
1.
go back to reference Centers for Disease Control and Prevention. The State of Aging and Health in America 2013. Centers for Disease Control and Prevention, US Dept of Health and Human Services 2013. Centers for Disease Control and Prevention. The State of Aging and Health in America 2013. Centers for Disease Control and Prevention, US Dept of Health and Human Services 2013.
2.
go back to reference Forman DE, Rich MW, Alexander KP, Zieman S, Maurer MS, Najjar SS, et al. Cardiac care for older adults. Time for a new paradigm. J Am Coll Cardiol. 2011;57:1801–10.PubMedCrossRef Forman DE, Rich MW, Alexander KP, Zieman S, Maurer MS, Najjar SS, et al. Cardiac care for older adults. Time for a new paradigm. J Am Coll Cardiol. 2011;57:1801–10.PubMedCrossRef
3.
go back to reference Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, et al. Heart disease and stroke statistics–2014 update: a report from the American Heart Association. Circulation. 2014;129:e28–292.PubMedCrossRef Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, et al. Heart disease and stroke statistics–2014 update: a report from the American Heart Association. Circulation. 2014;129:e28–292.PubMedCrossRef
4.
go back to reference Heidenreich PA, Trogdon JG, Khavjou OA, Butler J, Dracup K, Ezekowitz MD, et al. Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation. 2011;123:933–44.PubMedCrossRef Heidenreich PA, Trogdon JG, Khavjou OA, Butler J, Dracup K, Ezekowitz MD, et al. Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation. 2011;123:933–44.PubMedCrossRef
5.
go back to reference Qiu C, Winblad B, Marengoni A, Klarin I, Fastbom J, Fratiglioni L. Heart failure and risk of dementia and Alzheimer disease: a population-based cohort study. Arch Intern Med. 2006;166:1003–8.PubMedCrossRef Qiu C, Winblad B, Marengoni A, Klarin I, Fastbom J, Fratiglioni L. Heart failure and risk of dementia and Alzheimer disease: a population-based cohort study. Arch Intern Med. 2006;166:1003–8.PubMedCrossRef
6.
go back to reference Hjelm C, Brostrom A, Dahl A, Johansson B, Fredrikson M, Stromberg A. Factors associated with increased risk for dementia in individuals age 80 years or older with congestive heart failure. J Cardiovasc Nurs. 2014;29:82–90.PubMedCrossRef Hjelm C, Brostrom A, Dahl A, Johansson B, Fredrikson M, Stromberg A. Factors associated with increased risk for dementia in individuals age 80 years or older with congestive heart failure. J Cardiovasc Nurs. 2014;29:82–90.PubMedCrossRef
7.
go back to reference Rusanen M, Kivipelto M, Levalahti E, Laatikainen T, Tuomilehto J, Soininen H, et al. Heart diseases and long-term risk of dementia and Alzheimer's disease: a population-based CAIDE study. J Alzheimers Dis JAD. 2014;42(1):183–91. Rusanen M, Kivipelto M, Levalahti E, Laatikainen T, Tuomilehto J, Soininen H, et al. Heart diseases and long-term risk of dementia and Alzheimer's disease: a population-based CAIDE study. J Alzheimers Dis JAD. 2014;42(1):183–91.
8.
go back to reference Sattelmair JR, Pertman JH, Forman DE. Effects of physical activity on cardiovascular and noncardiovascular outcomes in older adults. Clin Geriatr Med. 2009;25:677–702. viii-ix.PubMedCrossRef Sattelmair JR, Pertman JH, Forman DE. Effects of physical activity on cardiovascular and noncardiovascular outcomes in older adults. Clin Geriatr Med. 2009;25:677–702. viii-ix.PubMedCrossRef
9.
go back to reference Kennedy KM, Raz N. Aging white matter and cognition: differential effects of regional variations in diffusion properties on memory, executive functions, and speed. Neuropsychologia. 2009;47:916–27.PubMedCentralPubMedCrossRef Kennedy KM, Raz N. Aging white matter and cognition: differential effects of regional variations in diffusion properties on memory, executive functions, and speed. Neuropsychologia. 2009;47:916–27.PubMedCentralPubMedCrossRef
10.••
go back to reference Goh JO, An Y, Resnick SM. Differential trajectories of age-related changes in components of executive and memory processes. Psychol Aging. 2012;27:707–19. This study examined both cross-sectional and longitudinal changes in components of executive function and memory. The findings highlight the heterogenity of age-related cognitive changes, as well as differences between cross-sectional and longitudinal approaches.PubMedCentralPubMedCrossRef Goh JO, An Y, Resnick SM. Differential trajectories of age-related changes in components of executive and memory processes. Psychol Aging. 2012;27:707–19. This study examined both cross-sectional and longitudinal changes in components of executive function and memory. The findings highlight the heterogenity of age-related cognitive changes, as well as differences between cross-sectional and longitudinal approaches.PubMedCentralPubMedCrossRef
11.
go back to reference Head D, Kennedy KM, Rodrigue KM, Raz N. Age differences in perseveration: cognitive and neuroanatomical mediators of performance on the Wisconsin Card Sorting Test. Neuropsychologia. 2009;47:1200–3.PubMedCentralPubMedCrossRef Head D, Kennedy KM, Rodrigue KM, Raz N. Age differences in perseveration: cognitive and neuroanatomical mediators of performance on the Wisconsin Card Sorting Test. Neuropsychologia. 2009;47:1200–3.PubMedCentralPubMedCrossRef
12.
go back to reference Salthouse TA. The processing-speed theory of adult age differences in cognition. Psychol Rev. 1996;103:403–28.PubMedCrossRef Salthouse TA. The processing-speed theory of adult age differences in cognition. Psychol Rev. 1996;103:403–28.PubMedCrossRef
13.
go back to reference Naveh-Benjamin M. Adult age differences in memory performance: tests of an associative deficit hypothesis. J Exp Psychol Learn Mem Cogn. 2000;26:1170–87.PubMedCrossRef Naveh-Benjamin M. Adult age differences in memory performance: tests of an associative deficit hypothesis. J Exp Psychol Learn Mem Cogn. 2000;26:1170–87.PubMedCrossRef
14.
15.
go back to reference Anderson ND, Ebert PL, Jennings JM, Grady CL, Cabeza R, Graham SJ. Recollection- and familiarity-based memory in healthy aging and amnestic mild cognitive impairment. Neuropsychology. 2008;22:177–87.PubMedCrossRef Anderson ND, Ebert PL, Jennings JM, Grady CL, Cabeza R, Graham SJ. Recollection- and familiarity-based memory in healthy aging and amnestic mild cognitive impairment. Neuropsychology. 2008;22:177–87.PubMedCrossRef
16.
go back to reference Cohen RA, Poppas A, Forman DE, Hoth KF, Haley AP, Gunstad J, et al. Vascular and cognitive functions associated with cardiovascular disease in the elderly. J Clin Exp Neuropsychol. 2009;31:96–110.PubMedCentralPubMedCrossRef Cohen RA, Poppas A, Forman DE, Hoth KF, Haley AP, Gunstad J, et al. Vascular and cognitive functions associated with cardiovascular disease in the elderly. J Clin Exp Neuropsychol. 2009;31:96–110.PubMedCentralPubMedCrossRef
17.
go back to reference O'Brien JT, Erkinjuntti T, Reisberg B, Roman G, Sawada T, Pantoni L, et al. Vascular cognitive impairment. Lancet Neurol. 2003;2:89–98.PubMedCrossRef O'Brien JT, Erkinjuntti T, Reisberg B, Roman G, Sawada T, Pantoni L, et al. Vascular cognitive impairment. Lancet Neurol. 2003;2:89–98.PubMedCrossRef
18.
go back to reference Roberts RO, Knopman DS, Przybelski SA, Mielke MM, Kantarci K, Preboske GM, et al. Association of type 2 diabetes with brain atrophy and cognitive impairment. Neurology. 2014;82:1132–41.PubMedCrossRef Roberts RO, Knopman DS, Przybelski SA, Mielke MM, Kantarci K, Preboske GM, et al. Association of type 2 diabetes with brain atrophy and cognitive impairment. Neurology. 2014;82:1132–41.PubMedCrossRef
19.
go back to reference Saxton J, Ratcliff G, Newman A, Belle S, Fried L, Yee J, et al. Cognitive test performance and presence of subclinical cardiovascular disease in the cardiovascular health study. Neuroepidemiology. 2000;19:312–9.PubMedCrossRef Saxton J, Ratcliff G, Newman A, Belle S, Fried L, Yee J, et al. Cognitive test performance and presence of subclinical cardiovascular disease in the cardiovascular health study. Neuroepidemiology. 2000;19:312–9.PubMedCrossRef
20.
go back to reference van Eersel ME, Joosten H, Gansevoort RT, Dullaart RP, Slaets JP, Izaks GJ. The interaction of age and type 2 diabetes on executive function and memory in persons aged 35 years or older. PLoS One. 2013;8:e82991.PubMedCentralPubMedCrossRef van Eersel ME, Joosten H, Gansevoort RT, Dullaart RP, Slaets JP, Izaks GJ. The interaction of age and type 2 diabetes on executive function and memory in persons aged 35 years or older. PLoS One. 2013;8:e82991.PubMedCentralPubMedCrossRef
21.
go back to reference Yaffe K, Vittinghoff E, Pletcher MJ, Hoang TD, Launer LJ, Whitmer R, et al. Early adult to midlife cardiovascular risk factors and cognitive function. Circulation. 2014;129:1560–7.PubMedCrossRef Yaffe K, Vittinghoff E, Pletcher MJ, Hoang TD, Launer LJ, Whitmer R, et al. Early adult to midlife cardiovascular risk factors and cognitive function. Circulation. 2014;129:1560–7.PubMedCrossRef
22.
go back to reference Almeida OP, Garrido GJ, Beer C, Lautenschlager NT, Arnolda L, Flicker L. Cognitive and brain changes associated with ischaemic heart disease and heart failure. Eur Heart J. 2012;33:1769–76.PubMedCrossRef Almeida OP, Garrido GJ, Beer C, Lautenschlager NT, Arnolda L, Flicker L. Cognitive and brain changes associated with ischaemic heart disease and heart failure. Eur Heart J. 2012;33:1769–76.PubMedCrossRef
23.
go back to reference Pressler SJ, Subramanian U, Kareken D, Perkins SM, Gradus-Pizlo I, Sauve MJ, et al. Cognitive deficits in chronic heart failure. Nurs Res. 2010;59:127–39.PubMedCentralPubMedCrossRef Pressler SJ, Subramanian U, Kareken D, Perkins SM, Gradus-Pizlo I, Sauve MJ, et al. Cognitive deficits in chronic heart failure. Nurs Res. 2010;59:127–39.PubMedCentralPubMedCrossRef
24.
go back to reference Stefansdottir H, Arnar DO, Aspelund T, Sigurdsson S, Jonsdottir MK, Hjaltason H, et al. Atrial fibrillation is associated with reduced brain volume and cognitive function independent of cerebral infarcts. Stroke J Cereb Circ. 2013;44:1020–5.CrossRef Stefansdottir H, Arnar DO, Aspelund T, Sigurdsson S, Jonsdottir MK, Hjaltason H, et al. Atrial fibrillation is associated with reduced brain volume and cognitive function independent of cerebral infarcts. Stroke J Cereb Circ. 2013;44:1020–5.CrossRef
25.
go back to reference Dregan A, Stewart R, Gulliford MC. Cardiovascular risk factors and cognitive decline in adults aged 50 and over: a population-based cohort study. Age Ageing. 2013;42:338–45.PubMedCrossRef Dregan A, Stewart R, Gulliford MC. Cardiovascular risk factors and cognitive decline in adults aged 50 and over: a population-based cohort study. Age Ageing. 2013;42:338–45.PubMedCrossRef
26.
go back to reference Kooistra M, Geerlings MI, van der Graaf Y, Mali WP, Vincken KL, Kappelle LJ, et al. Vascular brain lesions, brain atrophy, and cognitive decline. The Second Manifestations of ARTerial disease–Magnetic Resonance (SMART-MR) study. Neurobiol Aging. 2014;35:35–41.PubMedCrossRef Kooistra M, Geerlings MI, van der Graaf Y, Mali WP, Vincken KL, Kappelle LJ, et al. Vascular brain lesions, brain atrophy, and cognitive decline. The Second Manifestations of ARTerial disease–Magnetic Resonance (SMART-MR) study. Neurobiol Aging. 2014;35:35–41.PubMedCrossRef
27.
go back to reference Okonkwo OC, Cohen RA, Gunstad J, Tremont G, Alosco ML, Poppas A. Longitudinal trajectories of cognitive decline among older adults with cardiovascular disease. Cerebrovasc Dis. 2010;30:362–73.PubMedCentralPubMedCrossRef Okonkwo OC, Cohen RA, Gunstad J, Tremont G, Alosco ML, Poppas A. Longitudinal trajectories of cognitive decline among older adults with cardiovascular disease. Cerebrovasc Dis. 2010;30:362–73.PubMedCentralPubMedCrossRef
28.
go back to reference Thacker EL, McKnight B, Psaty BM, Longstreth Jr WT, Sitlani CM, Dublin S, et al. Atrial fibrillation and cognitive decline: a longitudinal cohort study. Neurology. 2013;81:119–25.PubMedCentralPubMedCrossRef Thacker EL, McKnight B, Psaty BM, Longstreth Jr WT, Sitlani CM, Dublin S, et al. Atrial fibrillation and cognitive decline: a longitudinal cohort study. Neurology. 2013;81:119–25.PubMedCentralPubMedCrossRef
29.
go back to reference Zheng L, Mack WJ, Chui HC, Heflin L, Mungas D, Reed B, et al. Coronary artery disease is associated with cognitive decline independent of changes on magnetic resonance imaging in cognitively normal elderly adults. J Am Geriatr Soc. 2012;60:499–504.PubMedCentralPubMedCrossRef Zheng L, Mack WJ, Chui HC, Heflin L, Mungas D, Reed B, et al. Coronary artery disease is associated with cognitive decline independent of changes on magnetic resonance imaging in cognitively normal elderly adults. J Am Geriatr Soc. 2012;60:499–504.PubMedCentralPubMedCrossRef
30.
go back to reference Walhovd KB, Westlye LT, Amlien I, Espeseth T, Reinvang I, Raz N, et al. Consistent neuroanatomical age-related volume differences across multiple samples. Neurobiol Aging. 2011;32:916–32.PubMedCentralPubMedCrossRef Walhovd KB, Westlye LT, Amlien I, Espeseth T, Reinvang I, Raz N, et al. Consistent neuroanatomical age-related volume differences across multiple samples. Neurobiol Aging. 2011;32:916–32.PubMedCentralPubMedCrossRef
31.
go back to reference Salat DH, Greve DN, Pacheco JL, Quinn BT, Helmer KG, Buckner RL, et al. Regional white matter volume differences in nondemented aging and Alzheimer's disease. Neuroimage. 2009;44:1247–58.PubMedCentralPubMedCrossRef Salat DH, Greve DN, Pacheco JL, Quinn BT, Helmer KG, Buckner RL, et al. Regional white matter volume differences in nondemented aging and Alzheimer's disease. Neuroimage. 2009;44:1247–58.PubMedCentralPubMedCrossRef
32.
go back to reference Raz N, Lindenberger U, Rodrigue KM, Kennedy KM, Head D, Williamson A, et al. Regional brain changes in aging healthy adults: general trends, individual differences and modifiers. Cereb Cortex. 2005;15:1676–89.PubMedCrossRef Raz N, Lindenberger U, Rodrigue KM, Kennedy KM, Head D, Williamson A, et al. Regional brain changes in aging healthy adults: general trends, individual differences and modifiers. Cereb Cortex. 2005;15:1676–89.PubMedCrossRef
33.
go back to reference O'Sullivan M, Jones DK, Summers PE, Morris RG, Williams SCR, Markus HS. Evidence for cortical "disconnection" as a mechanism of age-related cognitive decline. Neurology. 2001;57:632–8.PubMedCrossRef O'Sullivan M, Jones DK, Summers PE, Morris RG, Williams SCR, Markus HS. Evidence for cortical "disconnection" as a mechanism of age-related cognitive decline. Neurology. 2001;57:632–8.PubMedCrossRef
34.
go back to reference Salat DH, Tuch DS, Greve DN, van der Kouwe AJW, Hevelone ND, Zaleta AK, et al. Age-related alterations in white matter microstructure measured by diffusion tensor imaging. Neurobiol Aging. 2005;26:1215–27.PubMedCrossRef Salat DH, Tuch DS, Greve DN, van der Kouwe AJW, Hevelone ND, Zaleta AK, et al. Age-related alterations in white matter microstructure measured by diffusion tensor imaging. Neurobiol Aging. 2005;26:1215–27.PubMedCrossRef
35.
36.
go back to reference Ritchey M, Bessette-Symons B, Hayes SM, Cabeza R. Emotion processing in the aging brain is modulated by semantic elaboration. Neuropsychologia. 2011;49:640–50.PubMedCentralPubMedCrossRef Ritchey M, Bessette-Symons B, Hayes SM, Cabeza R. Emotion processing in the aging brain is modulated by semantic elaboration. Neuropsychologia. 2011;49:640–50.PubMedCentralPubMedCrossRef
37.
go back to reference Dulas MR, Duarte A. Aging affects the interaction between attentional control and source memory: an fMRI study. J Cogn Neurosci. 2014. Dulas MR, Duarte A. Aging affects the interaction between attentional control and source memory: an fMRI study. J Cogn Neurosci. 2014.
38.•
go back to reference Daselaar SM, Iyengar V, Davis SW, Eklund K, Hayes SM, Cabeza RE. Less wiring, more firing: low-performing older adults compensate for impaired white matter with greater neural activity. Cereb Cortex. 2013. This study integrated cognitive testing, functional MRI, and diffusion tensor imaging to delineate individual differences in cognitive and neural aging. White matter integrity was negatively correlated with fMRI activity, suggesting there may be functional compensation in the face of structrual deterioration. Daselaar SM, Iyengar V, Davis SW, Eklund K, Hayes SM, Cabeza RE. Less wiring, more firing: low-performing older adults compensate for impaired white matter with greater neural activity. Cereb Cortex. 2013. This study integrated cognitive testing, functional MRI, and diffusion tensor imaging to delineate individual differences in cognitive and neural aging. White matter integrity was negatively correlated with fMRI activity, suggesting there may be functional compensation in the face of structrual deterioration.
39.
go back to reference Rodrigue KM, Raz N. Shrinkage of the entorhinal cortex over five years predicts memory performance in healthy adults. J Neurosci. 2004;24:956–63.PubMedCrossRef Rodrigue KM, Raz N. Shrinkage of the entorhinal cortex over five years predicts memory performance in healthy adults. J Neurosci. 2004;24:956–63.PubMedCrossRef
40.
go back to reference Almeida OP, Garrido GJ, Etherton-Beer C, Lautenschlager NT, Arnolda L, Alfonso H, et al. Brain and mood changes over 2 years in healthy controls and adults with heart failure and ischaemic heart disease. Eur J Heart Fail. 2013;15:850–8.PubMedCrossRef Almeida OP, Garrido GJ, Etherton-Beer C, Lautenschlager NT, Arnolda L, Alfonso H, et al. Brain and mood changes over 2 years in healthy controls and adults with heart failure and ischaemic heart disease. Eur J Heart Fail. 2013;15:850–8.PubMedCrossRef
41.
go back to reference Kumar R, Woo MA, Birrer BV, Macey PM, Fonarow GC, Hamilton MA, et al. Mammillary bodies and fornix fibers are injured in heart failure. Neurobiol Dis. 2009;33:236–42.PubMedCentralPubMedCrossRef Kumar R, Woo MA, Birrer BV, Macey PM, Fonarow GC, Hamilton MA, et al. Mammillary bodies and fornix fibers are injured in heart failure. Neurobiol Dis. 2009;33:236–42.PubMedCentralPubMedCrossRef
42.
go back to reference Pan A, Kumar R, Macey PM, Fonarow GC, Harper RM, Woo MA. Visual assessment of brain magnetic resonance imaging detects injury to cognitive regulatory sites in patients with heart failure. J Card Fail. 2013;19:94–100.PubMedCrossRef Pan A, Kumar R, Macey PM, Fonarow GC, Harper RM, Woo MA. Visual assessment of brain magnetic resonance imaging detects injury to cognitive regulatory sites in patients with heart failure. J Card Fail. 2013;19:94–100.PubMedCrossRef
43.
44.
go back to reference Woo MA, Kumar R, Macey PM, Fonarow GC, Harper RM. Brain injury in autonomic, emotional, and cognitive regulatory areas in patients with heart failure. J Card Fail. 2009;15:214–23.PubMedCentralPubMedCrossRef Woo MA, Kumar R, Macey PM, Fonarow GC, Harper RM. Brain injury in autonomic, emotional, and cognitive regulatory areas in patients with heart failure. J Card Fail. 2009;15:214–23.PubMedCentralPubMedCrossRef
45.
go back to reference Beason-Held LL, Thambisetty M, Deib G, Sojkova J, Landman BA, Zonderman AB, et al. Baseline cardiovascular risk predicts subsequent changes in resting brain function. Stroke J Cereb Circ. 2012;43:1542–7.CrossRef Beason-Held LL, Thambisetty M, Deib G, Sojkova J, Landman BA, Zonderman AB, et al. Baseline cardiovascular risk predicts subsequent changes in resting brain function. Stroke J Cereb Circ. 2012;43:1542–7.CrossRef
46.
go back to reference Gruhn N, Larsen FS, Boesgaard S, Knudsen GM, Mortensen SA, Thomsen G, et al. Cerebral blood flow in patients with chronic heart failure before and after heart transplantation. Stroke J Cereb Circ. 2001;32:2530–3.CrossRef Gruhn N, Larsen FS, Boesgaard S, Knudsen GM, Mortensen SA, Thomsen G, et al. Cerebral blood flow in patients with chronic heart failure before and after heart transplantation. Stroke J Cereb Circ. 2001;32:2530–3.CrossRef
47.
go back to reference Braskie MN, Small GW, Bookheimer SY. Vascular health risks and fMRI activation during a memory task in older adults. Neurobiol Aging. 2010;31:1532–42.PubMedCentralPubMedCrossRef Braskie MN, Small GW, Bookheimer SY. Vascular health risks and fMRI activation during a memory task in older adults. Neurobiol Aging. 2010;31:1532–42.PubMedCentralPubMedCrossRef
48.
go back to reference Haley AP, Eagan DE, Gonzales MM, Biney FO, Cooper RA. Functional magnetic resonance imaging of working memory reveals frontal hypoactivation in middle-aged adults with cognitive complaints. J Int Neuropsychol Soc JINS. 2011;17:915–24.CrossRef Haley AP, Eagan DE, Gonzales MM, Biney FO, Cooper RA. Functional magnetic resonance imaging of working memory reveals frontal hypoactivation in middle-aged adults with cognitive complaints. J Int Neuropsychol Soc JINS. 2011;17:915–24.CrossRef
49.
go back to reference Chuang YF, Eldreth D, Erickson KI, Varma V, Harris G, Fried LP, et al. Cardiovascular risks and brain function: a functional magnetic resonance imaging study of executive function in older adults. Neurobiol Aging. 2014;35:1396–403.PubMedCrossRef Chuang YF, Eldreth D, Erickson KI, Varma V, Harris G, Fried LP, et al. Cardiovascular risks and brain function: a functional magnetic resonance imaging study of executive function in older adults. Neurobiol Aging. 2014;35:1396–403.PubMedCrossRef
50.
go back to reference Hoth KF, Gonzales MM, Tarumi T, Miles SC, Tanaka H, Haley AP. Functional MR imaging evidence of altered functional activation in metabolic syndrome. AJNR Am J Neuroradiol. 2011;32:541–7.PubMedCrossRef Hoth KF, Gonzales MM, Tarumi T, Miles SC, Tanaka H, Haley AP. Functional MR imaging evidence of altered functional activation in metabolic syndrome. AJNR Am J Neuroradiol. 2011;32:541–7.PubMedCrossRef
51.
go back to reference Li C, Zheng J, Wang J. An fMRI study of prefrontal cortical function in subcortical ischemic vascular cognitive impairment. Am J Alzheimers Dis Dementias. 2012;27:490–5.CrossRef Li C, Zheng J, Wang J. An fMRI study of prefrontal cortical function in subcortical ischemic vascular cognitive impairment. Am J Alzheimers Dis Dementias. 2012;27:490–5.CrossRef
52.
go back to reference Li C, Zheng J, Wang J, Gui L. Comparison between Alzheimer's disease and subcortical vascular dementia: attentional cortex study in functional magnetic resonance imaging. J Int Med Res. 2011;39:1413–9.PubMedCrossRef Li C, Zheng J, Wang J, Gui L. Comparison between Alzheimer's disease and subcortical vascular dementia: attentional cortex study in functional magnetic resonance imaging. J Int Med Res. 2011;39:1413–9.PubMedCrossRef
53.
go back to reference Alosco ML, Brickman AM, Spitznagel MB, Garcia SL, Narkhede A, Griffith EY, et al. Cerebral perfusion is associated with white matter hyperintensities in older adults with heart failure. Congestive Heart Fail. 2013;19:E29–34.CrossRef Alosco ML, Brickman AM, Spitznagel MB, Garcia SL, Narkhede A, Griffith EY, et al. Cerebral perfusion is associated with white matter hyperintensities in older adults with heart failure. Congestive Heart Fail. 2013;19:E29–34.CrossRef
54.
go back to reference Alosco ML, Gunstad J, Jerskey BA, Xu X, Clark US, Hassenstab J, et al. The adverse effects of reduced cerebral perfusion on cognition and brain structure in older adults with cardiovascular disease. Brain Behav. 2013;3:626–36.PubMedCentralPubMedCrossRef Alosco ML, Gunstad J, Jerskey BA, Xu X, Clark US, Hassenstab J, et al. The adverse effects of reduced cerebral perfusion on cognition and brain structure in older adults with cardiovascular disease. Brain Behav. 2013;3:626–36.PubMedCentralPubMedCrossRef
55.
go back to reference Vogels RL, Oosterman JM, van Harten B, Gouw AA, Schroeder-Tanka JM, Scheltens P, et al. Neuroimaging and correlates of cognitive function among patients with heart failure. Dement Geriatr Cogn Disord. 2007;24:418–23.PubMedCrossRef Vogels RL, Oosterman JM, van Harten B, Gouw AA, Schroeder-Tanka JM, Scheltens P, et al. Neuroimaging and correlates of cognitive function among patients with heart failure. Dement Geriatr Cogn Disord. 2007;24:418–23.PubMedCrossRef
56.
go back to reference Colcombe S, Kramer AF. Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci. 2003;14:125–30.PubMedCrossRef Colcombe S, Kramer AF. Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci. 2003;14:125–30.PubMedCrossRef
57.
go back to reference Smith PJ, Blumenthal JA, Hoffman BM, Cooper H, Strauman TA, Welsh-Bohmer K, et al. Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosom Med. 2010;72:239–52.PubMedCentralPubMedCrossRef Smith PJ, Blumenthal JA, Hoffman BM, Cooper H, Strauman TA, Welsh-Bohmer K, et al. Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosom Med. 2010;72:239–52.PubMedCentralPubMedCrossRef
58.
go back to reference Etnier JL, Nowell PM, Landers DM, Sibley BA. A meta-regression to examine the relationship between aerobic fitness and cognitive performance. Brain Res Rev. 2006;52:119–30.PubMedCrossRef Etnier JL, Nowell PM, Landers DM, Sibley BA. A meta-regression to examine the relationship between aerobic fitness and cognitive performance. Brain Res Rev. 2006;52:119–30.PubMedCrossRef
59.
go back to reference Langlois F, Vu TT, Chasse K, Dupuis G, Kergoat MJ, Bherer L. Benefits of physical exercise training on cognition and quality of life in frail older adults. J Gerontol B Psychol Sci Soc Sci. 2013;68:400–4.PubMedCrossRef Langlois F, Vu TT, Chasse K, Dupuis G, Kergoat MJ, Bherer L. Benefits of physical exercise training on cognition and quality of life in frail older adults. J Gerontol B Psychol Sci Soc Sci. 2013;68:400–4.PubMedCrossRef
60.
go back to reference Scardovi AB, De Maria R, Celestini A, Perna S, Coletta C, Feola M, et al. Additive prognostic value of cardiopulmonary exercise testing in elderly patients with heart failure. Clin Sci. 2009;116:415–22.PubMedCrossRef Scardovi AB, De Maria R, Celestini A, Perna S, Coletta C, Feola M, et al. Additive prognostic value of cardiopulmonary exercise testing in elderly patients with heart failure. Clin Sci. 2009;116:415–22.PubMedCrossRef
61.
go back to reference Alosco ML, Spitznagel MB, Miller L, Raz N, Cohen R, Sweet LH, et al. Depression is associated with reduced physical activity in persons with heart failure. Health Psychol Off J Div Health Psychol Am Psychol Assoc. 2012;31:754–62. Alosco ML, Spitznagel MB, Miller L, Raz N, Cohen R, Sweet LH, et al. Depression is associated with reduced physical activity in persons with heart failure. Health Psychol Off J Div Health Psychol Am Psychol Assoc. 2012;31:754–62.
62.
go back to reference Conraads VM, Deaton C, Piotrowicz E, Santaularia N, Tierney S, Piepoli MF, et al. Adherence of heart failure patients to exercise: barriers and possible solutions: a position statement of the Study Group on Exercise Training in Heart Failure of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2012;14:451–8.PubMedCrossRef Conraads VM, Deaton C, Piotrowicz E, Santaularia N, Tierney S, Piepoli MF, et al. Adherence of heart failure patients to exercise: barriers and possible solutions: a position statement of the Study Group on Exercise Training in Heart Failure of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2012;14:451–8.PubMedCrossRef
63.
go back to reference Lee YH, Yoon ES, Park SH, Heffernan KS, Lee C, Jae SY. Associations of arterial stiffness and cognitive function with physical fitness in patients with chronic stroke. J Rehabil Med. 2014;46:413–7.PubMedCrossRef Lee YH, Yoon ES, Park SH, Heffernan KS, Lee C, Jae SY. Associations of arterial stiffness and cognitive function with physical fitness in patients with chronic stroke. J Rehabil Med. 2014;46:413–7.PubMedCrossRef
64.
go back to reference Swardfager W, Herrmann N, Marzolini S, Saleem M, Kiss A, Shammi P, et al. Cardiopulmonary fitness is associated with cognitive performance in patients with coronary artery disease. J Am Geriatr Soc. 2010;58:1519–25.PubMedCrossRef Swardfager W, Herrmann N, Marzolini S, Saleem M, Kiss A, Shammi P, et al. Cardiopulmonary fitness is associated with cognitive performance in patients with coronary artery disease. J Am Geriatr Soc. 2010;58:1519–25.PubMedCrossRef
65.
go back to reference Garcia S, Alosco ML, Spitznagel MB, Cohen R, Raz N, Sweet L, et al. Cardiovascular fitness associated with cognitive performance in heart failure patients enrolled in cardiac rehabilitation. BMC Cardiovasc Disord. 2013;13:29.PubMedCentralPubMedCrossRef Garcia S, Alosco ML, Spitznagel MB, Cohen R, Raz N, Sweet L, et al. Cardiovascular fitness associated with cognitive performance in heart failure patients enrolled in cardiac rehabilitation. BMC Cardiovasc Disord. 2013;13:29.PubMedCentralPubMedCrossRef
66.
go back to reference Thompson RH, Leibovich BC, Lohse CM, Zincke H, Blute ML. Complications of contemporary open nephron sparing surgery: a single institution experience. J Urol. 2005;174:855–8.PubMedCrossRef Thompson RH, Leibovich BC, Lohse CM, Zincke H, Blute ML. Complications of contemporary open nephron sparing surgery: a single institution experience. J Urol. 2005;174:855–8.PubMedCrossRef
67.
go back to reference Van Laethem C, Van De Veire N, De Backer G, Bihija S, Seghers T, Cambier D, et al. Response of the oxygen uptake efficiency slope to exercise training in patients with chronic heart failure. Eur J Heart Fail. 2007;9:625–9.PubMedCrossRef Van Laethem C, Van De Veire N, De Backer G, Bihija S, Seghers T, Cambier D, et al. Response of the oxygen uptake efficiency slope to exercise training in patients with chronic heart failure. Eur J Heart Fail. 2007;9:625–9.PubMedCrossRef
68.
go back to reference Stanek KM, Gunstad J, Spitznagel MB, Waechter D, Hughes JW, Luyster F, et al. Improvements in cognitive function following cardiac rehabilitation for older adults with cardiovascular disease. Int J Neurosci. 2011;121:86–93.PubMedCrossRef Stanek KM, Gunstad J, Spitznagel MB, Waechter D, Hughes JW, Luyster F, et al. Improvements in cognitive function following cardiac rehabilitation for older adults with cardiovascular disease. Int J Neurosci. 2011;121:86–93.PubMedCrossRef
69.
go back to reference Gunstad J, Macgregor KL, Paul RH, Poppas A, Jefferson AL, Todaro JF, et al. Cardiac rehabilitation improves cognitive performance in older adults with cardiovascular disease. J Cardpulm Rehabil. 2005;25:173–6.CrossRef Gunstad J, Macgregor KL, Paul RH, Poppas A, Jefferson AL, Todaro JF, et al. Cardiac rehabilitation improves cognitive performance in older adults with cardiovascular disease. J Cardpulm Rehabil. 2005;25:173–6.CrossRef
70.
go back to reference Tanne D, Freimark D, Poreh A, Merzeliak O, Bruck B, Schwammenthal Y, et al. Cognitive functions in severe congestive heart failure before and after an exercise training program. Int J Cardiol. 2005;103:145–9.PubMedCrossRef Tanne D, Freimark D, Poreh A, Merzeliak O, Bruck B, Schwammenthal Y, et al. Cognitive functions in severe congestive heart failure before and after an exercise training program. Int J Cardiol. 2005;103:145–9.PubMedCrossRef
71.
go back to reference Marzolini S, Oh P, McIlroy W, Brooks D. The effects of an aerobic and resistance exercise training program on cognition following stroke. Neurorehabil Neural Repair. 2013;27:392–402.PubMedCrossRef Marzolini S, Oh P, McIlroy W, Brooks D. The effects of an aerobic and resistance exercise training program on cognition following stroke. Neurorehabil Neural Repair. 2013;27:392–402.PubMedCrossRef
72.•
go back to reference Alosco ML, Spitznagel MB, Cohen R, Sweet LH, Josephson R, Hughes J, Gunstad J. Decreases in BMI after cardiac rehabilitation predict improved cognitive function in older adults with heart failure. J Am Geriatr Soc. 2014. This study found significant improvements in attention/executive function and memory following 12-weeks of cardic rehabilitation among 50 patients with heart failure. Alosco ML, Spitznagel MB, Cohen R, Sweet LH, Josephson R, Hughes J, Gunstad J. Decreases in BMI after cardiac rehabilitation predict improved cognitive function in older adults with heart failure. J Am Geriatr Soc. 2014. This study found significant improvements in attention/executive function and memory following 12-weeks of cardic rehabilitation among 50 patients with heart failure.
73.
go back to reference Erickson KI, Raji CA, Lopez OL, Becker JT, Rosano C, Newman AB, et al. Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study. Neurology. 2010;75:1415–22.PubMedCentralPubMedCrossRef Erickson KI, Raji CA, Lopez OL, Becker JT, Rosano C, Newman AB, et al. Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study. Neurology. 2010;75:1415–22.PubMedCentralPubMedCrossRef
74.
go back to reference Fulcher KK, Alosco ML, Miller L, Spitznagel MB, Cohen R, Raz N, Sweet L, Colbert LH, Josephson R, Hughes J. et al. Greater physical activity is associated with better cognitive function in heart failure. Health Psychol Off J Div Health Psychol Am Psychol Assoc. 2014. Fulcher KK, Alosco ML, Miller L, Spitznagel MB, Cohen R, Raz N, Sweet L, Colbert LH, Josephson R, Hughes J. et al. Greater physical activity is associated with better cognitive function in heart failure. Health Psychol Off J Div Health Psychol Am Psychol Assoc. 2014.
75.
go back to reference Colcombe SJ, Erickson KI, Scalf PE, Kim JS, Prakash R, McAuley E, et al. Aerobic exercise training increases brain volume in aging humans. J Gerontol Ser A Biol Sci Med Sci. 2006;61:1166–70.CrossRef Colcombe SJ, Erickson KI, Scalf PE, Kim JS, Prakash R, McAuley E, et al. Aerobic exercise training increases brain volume in aging humans. J Gerontol Ser A Biol Sci Med Sci. 2006;61:1166–70.CrossRef
76.
go back to reference Ruscheweyh R, Willemer C, Kruger K, Duning T, Warnecke T, Sommer J, et al. Physical activity and memory functions: an interventional study. Neurobiol Aging. 2011;32:1304–19.PubMedCrossRef Ruscheweyh R, Willemer C, Kruger K, Duning T, Warnecke T, Sommer J, et al. Physical activity and memory functions: an interventional study. Neurobiol Aging. 2011;32:1304–19.PubMedCrossRef
77.
go back to reference Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, et al. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci U S A. 2011;108:3017–22.PubMedCentralPubMedCrossRef Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, et al. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci U S A. 2011;108:3017–22.PubMedCentralPubMedCrossRef
78.
go back to reference Raz N, Rodrigue KM, Head D, Kennedy KM, Acker JD. Differential aging of the medial temporal lobe - A study of a five-year change. Neurology. 2004;62:433–8.PubMedCrossRef Raz N, Rodrigue KM, Head D, Kennedy KM, Acker JD. Differential aging of the medial temporal lobe - A study of a five-year change. Neurology. 2004;62:433–8.PubMedCrossRef
79.
go back to reference Colcombe SJ, Kramer AF, Erickson KI, Scalf P, McAuley E, Cohen NJ, et al. Cardiovascular fitness, cortical plasticity, and aging. Proc Natl Acad Sci U S A. 2004;101:3316–21. Colcombe SJ, Kramer AF, Erickson KI, Scalf P, McAuley E, Cohen NJ, et al. Cardiovascular fitness, cortical plasticity, and aging. Proc Natl Acad Sci U S A. 2004;101:3316–21.
80.
go back to reference Voelcker-Rehage C, Godde B, Staudinger UM. Cardiovascular and coordination training differentially improve cognitive performance and neural processing in older adults. Front Hum Neurosci. 2011; 5. Voelcker-Rehage C, Godde B, Staudinger UM. Cardiovascular and coordination training differentially improve cognitive performance and neural processing in older adults. Front Hum Neurosci. 2011; 5.
81.
go back to reference Voss MW, Prakash RS, Erickson KI, Basak C, Chaddock L, Kim JS, Alves H, Heo S, Szabo AN, White SM. et al. Plasticity of brain networks in a randomized intervention trial of exercise training in older adults. Front Aging Neurosci. 2010; 2. Voss MW, Prakash RS, Erickson KI, Basak C, Chaddock L, Kim JS, Alves H, Heo S, Szabo AN, White SM. et al. Plasticity of brain networks in a randomized intervention trial of exercise training in older adults. Front Aging Neurosci. 2010; 2.
82.•
go back to reference MacIntosh BJ, Swardfager W, Crane DE, Ranepura N, Saleem M, Oh PI, et al. Cardiopulmonary fitness correlates with regional cerebral grey matter perfusion and density in men with coronary artery disease. PLoS One. 2014;9:e91251. This study found a significant association between VO2 peak and cerebral perfusion and gray matter density in patients with coronary artery disease.PubMedCentralPubMedCrossRef MacIntosh BJ, Swardfager W, Crane DE, Ranepura N, Saleem M, Oh PI, et al. Cardiopulmonary fitness correlates with regional cerebral grey matter perfusion and density in men with coronary artery disease. PLoS One. 2014;9:e91251. This study found a significant association between VO2 peak and cerebral perfusion and gray matter density in patients with coronary artery disease.PubMedCentralPubMedCrossRef
83.
go back to reference Sen A, Gider P, Cavalieri M, Freudenberger P, Farzi A, Schallert M, et al. Association of cardiorespiratory fitness and morphological brain changes in the elderly: results of the Austrian Stroke Prevention Study. Neurodegener Dis. 2012;10:135–7.PubMedCrossRef Sen A, Gider P, Cavalieri M, Freudenberger P, Farzi A, Schallert M, et al. Association of cardiorespiratory fitness and morphological brain changes in the elderly: results of the Austrian Stroke Prevention Study. Neurodegener Dis. 2012;10:135–7.PubMedCrossRef
84.
go back to reference Alosco ML, Brickman AM, Spitznagel MB, Griffith EY, Narkhede A, Raz N, et al. Poorer physical fitness is associated with reduced structural brain integrity in heart failure. J Neurol Sci. 2013;328:51–7.PubMedCentralPubMedCrossRef Alosco ML, Brickman AM, Spitznagel MB, Griffith EY, Narkhede A, Raz N, et al. Poorer physical fitness is associated with reduced structural brain integrity in heart failure. J Neurol Sci. 2013;328:51–7.PubMedCentralPubMedCrossRef
85.
go back to reference Hambrecht R, Fiehn E, Weigl C, Gielen S, Hamann C, Kaiser R, et al. Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation. 1998;98:2709–15.PubMedCrossRef Hambrecht R, Fiehn E, Weigl C, Gielen S, Hamann C, Kaiser R, et al. Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation. 1998;98:2709–15.PubMedCrossRef
86.
go back to reference Murrell CJ, Cotter JD, Thomas KN, Lucas SJ, Williams MJ, Ainslie PN. Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: effect of age and 12-week exercise training. Age. 2013;35:905–20.PubMedCentralPubMedCrossRef Murrell CJ, Cotter JD, Thomas KN, Lucas SJ, Williams MJ, Ainslie PN. Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: effect of age and 12-week exercise training. Age. 2013;35:905–20.PubMedCentralPubMedCrossRef
87.••
go back to reference Anazodo UC, Shoemaker JK, Suskin N, St Lawrence KS. An investigation of changes in regional gray matter volume in cardiovascular disease patients, pre and post cardiovascular rehabilitation. NeuroImage Clin. 2013;3:388–95. This case-controlled study showed that baseline gray matter volume reductions in patients with cardiovascular disease recovered six-months after cardiovascular rehabilitation.PubMedCentralPubMedCrossRef Anazodo UC, Shoemaker JK, Suskin N, St Lawrence KS. An investigation of changes in regional gray matter volume in cardiovascular disease patients, pre and post cardiovascular rehabilitation. NeuroImage Clin. 2013;3:388–95. This case-controlled study showed that baseline gray matter volume reductions in patients with cardiovascular disease recovered six-months after cardiovascular rehabilitation.PubMedCentralPubMedCrossRef
88.•
go back to reference Kooistra M, Boss HM, van der Graaf Y, Kappelle LJ, Biessels GJ, Geerlings MI, et al. Physical activity, structural brain changes and cognitive decline. The SMART-MR study. Atherosclerosis. 2014;234:47–53. Findings from this study revealed greater self-reported physical activity at baseline was associated with larger total brain volume, as well as a trend for smaller ventricular volume and decreased risk for brain infarcts among a sample of 1,232 participants with vascular disease.PubMedCrossRef Kooistra M, Boss HM, van der Graaf Y, Kappelle LJ, Biessels GJ, Geerlings MI, et al. Physical activity, structural brain changes and cognitive decline. The SMART-MR study. Atherosclerosis. 2014;234:47–53. Findings from this study revealed greater self-reported physical activity at baseline was associated with larger total brain volume, as well as a trend for smaller ventricular volume and decreased risk for brain infarcts among a sample of 1,232 participants with vascular disease.PubMedCrossRef
89.•
go back to reference Gons RA, Tuladhar AM, de Laat KF, van Norden AG, van Dijk EJ, Norris DG, et al. Physical activity is related to the structural integrity of cerebral white matter. Neurology. 2013;81:971–6. This study demonstrated that greater levels of self-reported physical activity were associated with enhanced white matter integrity among a sample of 440 individuals with cerebral small vessel disease.PubMedCrossRef Gons RA, Tuladhar AM, de Laat KF, van Norden AG, van Dijk EJ, Norris DG, et al. Physical activity is related to the structural integrity of cerebral white matter. Neurology. 2013;81:971–6. This study demonstrated that greater levels of self-reported physical activity were associated with enhanced white matter integrity among a sample of 440 individuals with cerebral small vessel disease.PubMedCrossRef
90.
go back to reference Luft AR, Macko RF, Forrester LW, Villagra F, Ivey F, Sorkin JD, et al. Treadmill exercise activates subcortical neural networks and improves walking after stroke: a randomized controlled trial. Stroke J Cereb Circ. 2008;39:3341–50.CrossRef Luft AR, Macko RF, Forrester LW, Villagra F, Ivey F, Sorkin JD, et al. Treadmill exercise activates subcortical neural networks and improves walking after stroke: a randomized controlled trial. Stroke J Cereb Circ. 2008;39:3341–50.CrossRef
91.••
go back to reference Hayes SM, Hayes JP, Cadden M, Verfaellie M. A review of cardiorespiratory fitness-related neuroplasticity in the aging brain. Front Aging Neurosci. 2013;5:31. This comprehensive review summarizes the literature examining cardiorespiratory fitness-related changes in neural structure and function in healthy older adults.PubMedCentralPubMedCrossRef Hayes SM, Hayes JP, Cadden M, Verfaellie M. A review of cardiorespiratory fitness-related neuroplasticity in the aging brain. Front Aging Neurosci. 2013;5:31. This comprehensive review summarizes the literature examining cardiorespiratory fitness-related changes in neural structure and function in healthy older adults.PubMedCentralPubMedCrossRef
92.
go back to reference Pereira AC, Huddleston DE, Brickman AM, Sosunov AA, Hen R, McKhann GM, et al. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci U S A. 2007;104:5638–43.PubMedCentralPubMedCrossRef Pereira AC, Huddleston DE, Brickman AM, Sosunov AA, Hen R, McKhann GM, et al. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci U S A. 2007;104:5638–43.PubMedCentralPubMedCrossRef
93.
go back to reference Chapman SB, Aslan S, Spence JS, Defina LF, Keebler MW, Didehbani N, et al. Shorter term aerobic exercise improves brain, cognition, and cardiovascular fitness in aging. Front Aging Neurosci. 2013;5:75.PubMedCentralPubMedCrossRef Chapman SB, Aslan S, Spence JS, Defina LF, Keebler MW, Didehbani N, et al. Shorter term aerobic exercise improves brain, cognition, and cardiovascular fitness in aging. Front Aging Neurosci. 2013;5:75.PubMedCentralPubMedCrossRef
94.
go back to reference Tseng BY, Gundapuneedi T, Khan MA, Diaz-Arrastia R, Levine BD, Lu H, et al. White matter integrity in physically fit older adults. Neuroimage. 2013;82:510–6.PubMedCrossRef Tseng BY, Gundapuneedi T, Khan MA, Diaz-Arrastia R, Levine BD, Lu H, et al. White matter integrity in physically fit older adults. Neuroimage. 2013;82:510–6.PubMedCrossRef
95.
go back to reference Johnson NF, Kim C, Clasey JL, Bailey A, Gold BT. Cardiorespiratory fitness is positively correlated with cerebral white matter integrity in healthy seniors. Neuroimage. 2012;59:1514–23.PubMedCentralPubMedCrossRef Johnson NF, Kim C, Clasey JL, Bailey A, Gold BT. Cardiorespiratory fitness is positively correlated with cerebral white matter integrity in healthy seniors. Neuroimage. 2012;59:1514–23.PubMedCentralPubMedCrossRef
96.
go back to reference Voss MW, Heo S, Prakash RS, Erickson KI, Alves H, Chaddock L, et al. The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: results of a one-year exercise intervention. Hum Brain Mapp. 2012;34(11):2972–85.PubMedCrossRef Voss MW, Heo S, Prakash RS, Erickson KI, Alves H, Chaddock L, et al. The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: results of a one-year exercise intervention. Hum Brain Mapp. 2012;34(11):2972–85.PubMedCrossRef
97.
go back to reference Cotman CW, Berchtold NC, Christie LA. Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci. 2007;30:464–72.PubMedCrossRef Cotman CW, Berchtold NC, Christie LA. Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci. 2007;30:464–72.PubMedCrossRef
99.
go back to reference Nagamatsu LS, Handy TC, Hsu CL, Voss M, Liu-Ambrose T. Resistance training promotes cognitive and functional brain plasticity in seniors with probable mild cognitive impairment. Arch Intern Med. 2012;172:666–8.PubMedCentralPubMedCrossRef Nagamatsu LS, Handy TC, Hsu CL, Voss M, Liu-Ambrose T. Resistance training promotes cognitive and functional brain plasticity in seniors with probable mild cognitive impairment. Arch Intern Med. 2012;172:666–8.PubMedCentralPubMedCrossRef
100.
go back to reference Liu-Ambrose T, Nagamatsu LS, Voss MW, Khan KM, Handy TC. Resistance training and functional plasticity of the aging brain: a 12-month randomized controlled trial. Neurobiol Aging. 2012;33:1690–8.PubMedCrossRef Liu-Ambrose T, Nagamatsu LS, Voss MW, Khan KM, Handy TC. Resistance training and functional plasticity of the aging brain: a 12-month randomized controlled trial. Neurobiol Aging. 2012;33:1690–8.PubMedCrossRef
101.
go back to reference Voelcker-Rehage C, Niemann C. Structural and functional brain changes related to different types of physical activity across the life span. Neurosci Biobehav Rev. 2013;37(9 Pt B):2268–95.PubMedCrossRef Voelcker-Rehage C, Niemann C. Structural and functional brain changes related to different types of physical activity across the life span. Neurosci Biobehav Rev. 2013;37(9 Pt B):2268–95.PubMedCrossRef
Metadata
Title
The Effects of Aerobic Exercise on Cognitive and Neural Decline in Aging and Cardiovascular Disease
Authors
Scott M. Hayes
Michael L. Alosco
Daniel E. Forman
Publication date
01-12-2014
Publisher
Springer US
Published in
Current Geriatrics Reports / Issue 4/2014
Electronic ISSN: 2196-7865
DOI
https://doi.org/10.1007/s13670-014-0101-x

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