Skip to main content
Top
Published in: Current Geriatrics Reports 1/2014

01-03-2014 | Geriatric Urology (TJ Guzzo and DJ Canter, Section Editors)

The Use of Frailty as a Surgical Risk Assessment Tool in Elderly Patients

Authors: Louis M. Revenig, Kenneth Ogan, Thomas J. Guzzo, Daniel J. Canter

Published in: Current Geriatrics Reports | Issue 1/2014

Login to get access

Abstract

With the continued aging of the population, a rising proportion of surgical procedures will be performed in elderly patients. Current surgical decision-making tools rely on subjective judgments and were developed without special geriatric considerations. As a result, they have certain inadequacies that limit their utility in this population. Frailty, described for decades by the medical geriatric community, has just recently begun to be investigated as a surgical risk assessment tool. Identifying the frailty phenotype has been shown by multiple investigators to reliably predict which patients are at increased risk of adverse peri-operative outcomes. Perhaps, most importantly, it is a tool that can potentially discriminate among the elderly, identifying those that warrant heightened concern, "pre-habilitation", or special postoperative attention from those at no increased risk compared to the general population. Alternatively, some patients may be identified as “too frail” to undergo surgery, and alternative nonsurgical treatment options may be considered.
Literature
1.
go back to reference Hamel MB, Henderson WG, Khuri SF, Daley J. Surgical outcomes for patients aged 80 and older: morbidity and mortality from major noncardiac surgery. J Am Geriatr Soc. 2005;53(3):424–9.PubMedCrossRef Hamel MB, Henderson WG, Khuri SF, Daley J. Surgical outcomes for patients aged 80 and older: morbidity and mortality from major noncardiac surgery. J Am Geriatr Soc. 2005;53(3):424–9.PubMedCrossRef
2.•
go back to reference Colloca G, Santoro M, Gambassi G. Age-related physiologic changes and perioperative management of elderly patients. Surg Oncol. 2010;19(3):124–30. This review article is a comprehensive summary of the age-related changes in physiology that place patients at increased peri-operative risk. It also includes recommendations for peri-operative management of patients’ with special physiologic and pharmacodynamic derangements.PubMedCrossRef Colloca G, Santoro M, Gambassi G. Age-related physiologic changes and perioperative management of elderly patients. Surg Oncol. 2010;19(3):124–30. This review article is a comprehensive summary of the age-related changes in physiology that place patients at increased peri-operative risk. It also includes recommendations for peri-operative management of patients’ with special physiologic and pharmacodynamic derangements.PubMedCrossRef
3.
go back to reference Olivetti G, Melissari M, Capasso JM, Anversa P. Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy. Circ Res. 1991;68(6):1560–8.PubMedCrossRef Olivetti G, Melissari M, Capasso JM, Anversa P. Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy. Circ Res. 1991;68(6):1560–8.PubMedCrossRef
4.
go back to reference Nagai Y, Metter EJ, Earley CJ, Kemper MK, Becker LC, Lakatta EG, et al. Increased carotid artery intimal-medial thickness in asymptomatic older subjects with exercise-induced myocardial ischemia. Circulation. 1998;98(15):1504–9.PubMedCrossRef Nagai Y, Metter EJ, Earley CJ, Kemper MK, Becker LC, Lakatta EG, et al. Increased carotid artery intimal-medial thickness in asymptomatic older subjects with exercise-induced myocardial ischemia. Circulation. 1998;98(15):1504–9.PubMedCrossRef
5.
go back to reference O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson Jr SK. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med. 1999;340(1):14–22.PubMedCrossRef O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson Jr SK. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med. 1999;340(1):14–22.PubMedCrossRef
6.
go back to reference Verbeken EK, Cauberghs M, Mertens I, Clement J, Lauweryns JM, Van de Woestijne KP. The senile lung. Comparison with normal and emphysematous lungs. 2. Functional aspects. Chest. 1992;101(3):800–9.PubMedCrossRef Verbeken EK, Cauberghs M, Mertens I, Clement J, Lauweryns JM, Van de Woestijne KP. The senile lung. Comparison with normal and emphysematous lungs. 2. Functional aspects. Chest. 1992;101(3):800–9.PubMedCrossRef
7.
go back to reference Tolep K, Kelsen SG. Effect of aging on respiratory skeletal muscles. Clin Chest Med. 1993;14(3):363–78.PubMed Tolep K, Kelsen SG. Effect of aging on respiratory skeletal muscles. Clin Chest Med. 1993;14(3):363–78.PubMed
8.
go back to reference Krumpe PE, Knudson RJ, Parsons G, Reiser K. The aging respiratory system. Clin Geriatr Med. 1985;1(1):143–75.PubMed Krumpe PE, Knudson RJ, Parsons G, Reiser K. The aging respiratory system. Clin Geriatr Med. 1985;1(1):143–75.PubMed
9.
go back to reference Rowe JW, Andres R, Tobin JD, Norris AH, Shock NW. The effect of age on creatinine clearance in men: a cross-sectional and longitudinal study. J Gerontol. 1976;31(2):155–63.PubMedCrossRef Rowe JW, Andres R, Tobin JD, Norris AH, Shock NW. The effect of age on creatinine clearance in men: a cross-sectional and longitudinal study. J Gerontol. 1976;31(2):155–63.PubMedCrossRef
10.
go back to reference Musso CG, Oreopoulos DG. Aging and physiological changes of the kidneys including changes in glomerular filtration rate. Nephron Physiol. 2011;119 Suppl 1:1–5.CrossRef Musso CG, Oreopoulos DG. Aging and physiological changes of the kidneys including changes in glomerular filtration rate. Nephron Physiol. 2011;119 Suppl 1:1–5.CrossRef
11.
go back to reference Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med. 1999;130(6):461–70.PubMedCrossRef Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med. 1999;130(6):461–70.PubMedCrossRef
12.
go back to reference Gardner GJ. Ovarian cancer cytoreductive surgery in the elderly. Curr Treat Options Oncol. 2009;10(3–4):171–9.PubMedCrossRef Gardner GJ. Ovarian cancer cytoreductive surgery in the elderly. Curr Treat Options Oncol. 2009;10(3–4):171–9.PubMedCrossRef
13.
go back to reference Berry MF, Hanna J, Tong BC, Burfeind Jr WR, Harpole DH, D'Amico TA, et al. Risk factors for morbidity after lobectomy for lung cancer in elderly patients. Ann Thorac Surg. 2009;88(4):1093–9.PubMedCrossRef Berry MF, Hanna J, Tong BC, Burfeind Jr WR, Harpole DH, D'Amico TA, et al. Risk factors for morbidity after lobectomy for lung cancer in elderly patients. Ann Thorac Surg. 2009;88(4):1093–9.PubMedCrossRef
14.
go back to reference Balducci L, Yates J. General guidelines for the management of older patients with cancer. Oncology (Williston Park). 2000;14(11A):221–7. Balducci L, Yates J. General guidelines for the management of older patients with cancer. Oncology (Williston Park). 2000;14(11A):221–7.
15.
go back to reference Extermann M, Aapro M, Bernabei R, Cohen HJ, Droz JP, Lichtman S, et al. Task Force on CGA of the International Society of Geriatric Oncology. Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG). Crit Rev Oncol Hematol. 2005;55(3):241–52.PubMedCrossRef Extermann M, Aapro M, Bernabei R, Cohen HJ, Droz JP, Lichtman S, et al. Task Force on CGA of the International Society of Geriatric Oncology. Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG). Crit Rev Oncol Hematol. 2005;55(3):241–52.PubMedCrossRef
17.
go back to reference Leung JM, Dzankic S. Relative importance of preoperative health status versus intraoperative factors in predicting postoperative adverse outcomes in geriatric surgical patients. J Am Geriatr Soc. 2001;49(8):1080–5.PubMedCrossRef Leung JM, Dzankic S. Relative importance of preoperative health status versus intraoperative factors in predicting postoperative adverse outcomes in geriatric surgical patients. J Am Geriatr Soc. 2001;49(8):1080–5.PubMedCrossRef
18.
go back to reference Saklad M. Grading of patients for surgical procedures. Anesthesiology. 1941;2:281–4.CrossRef Saklad M. Grading of patients for surgical procedures. Anesthesiology. 1941;2:281–4.CrossRef
19.
go back to reference Bowles TA, Sanders KM, Colson M, Watters DA. Simplified risk stratification in elective colorectal surgery. ANZ J Surg. 2008;78(1–2):24–7.PubMedCrossRef Bowles TA, Sanders KM, Colson M, Watters DA. Simplified risk stratification in elective colorectal surgery. ANZ J Surg. 2008;78(1–2):24–7.PubMedCrossRef
20.
go back to reference Aronson WL, McAuliffe MS, Miller K. Variability in the American Society of anesthesiologists physical status classification scale. AANA J. 2003;71(4):265–74.PubMed Aronson WL, McAuliffe MS, Miller K. Variability in the American Society of anesthesiologists physical status classification scale. AANA J. 2003;71(4):265–74.PubMed
21.
go back to reference Balducci L, Beghe C. The application of the principles of geriatrics to the management of the older person with cancer. Crit Rev Oncol Hematol. 2000;35(3):147–54.PubMedCrossRef Balducci L, Beghe C. The application of the principles of geriatrics to the management of the older person with cancer. Crit Rev Oncol Hematol. 2000;35(3):147–54.PubMedCrossRef
22.
go back to reference Stuck AE, Siu AL, Wieland GD, Adams J, Rubenstein LZ. Comprehensive geriatric assessment: a meta-analysis of controlled trials. Lancet. 1993;342(8878):1032–6.PubMedCrossRef Stuck AE, Siu AL, Wieland GD, Adams J, Rubenstein LZ. Comprehensive geriatric assessment: a meta-analysis of controlled trials. Lancet. 1993;342(8878):1032–6.PubMedCrossRef
23.
go back to reference Pope D, Ramesh H, Gennari R, Corsini G, Maffezzini M, Hoekstra HJ, et al. Pre-operative assessment of cancer in the elderly (PACE): a comprehensive assessment of underlying characteristics of elderly cancer patients prior to elective surgery. Surg Oncol. 2006;15(4):189–97.PubMedCrossRef Pope D, Ramesh H, Gennari R, Corsini G, Maffezzini M, Hoekstra HJ, et al. Pre-operative assessment of cancer in the elderly (PACE): a comprehensive assessment of underlying characteristics of elderly cancer patients prior to elective surgery. Surg Oncol. 2006;15(4):189–97.PubMedCrossRef
24.••
go back to reference Rockwood K, Mitnitski A. Frailty in relation to the accumulation of deficits. J Gerontol A Biol Sci Med Sci. 2007;62(7):722–7. A comprehensive review article on assessing frailty according to the deficit accumulation model. The authors summarize the literature, particularly the implications of considering signs, symptoms, diseases, and disabilities as markers of frailty placing patients at increased risk for poor outcomes.PubMedCrossRef Rockwood K, Mitnitski A. Frailty in relation to the accumulation of deficits. J Gerontol A Biol Sci Med Sci. 2007;62(7):722–7. A comprehensive review article on assessing frailty according to the deficit accumulation model. The authors summarize the literature, particularly the implications of considering signs, symptoms, diseases, and disabilities as markers of frailty placing patients at increased risk for poor outcomes.PubMedCrossRef
25.••
go back to reference Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56. Large, prospective study that defined frailty as a distinct clinical syndrome characterized by weight loss, weakness, slowed gait speed, low activity, and exhaustion. Community dwelling frail patients were shown to be at increased risk for falls, hospitalizations, disability, institutionalization, and mortality. Particularly important as it led to the adaptation of frailty assessments to surgical cohorts.PubMedCrossRef Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56. Large, prospective study that defined frailty as a distinct clinical syndrome characterized by weight loss, weakness, slowed gait speed, low activity, and exhaustion. Community dwelling frail patients were shown to be at increased risk for falls, hospitalizations, disability, institutionalization, and mortality. Particularly important as it led to the adaptation of frailty assessments to surgical cohorts.PubMedCrossRef
26.
go back to reference Mitnitski AB, Mogilner AJ, MacKnight C, Rockwood K. The mortality rate as a function of accumulated deficits in a frailty index. Mech Ageing Dev. 2002;123(11):1457–60.PubMedCrossRef Mitnitski AB, Mogilner AJ, MacKnight C, Rockwood K. The mortality rate as a function of accumulated deficits in a frailty index. Mech Ageing Dev. 2002;123(11):1457–60.PubMedCrossRef
27.
go back to reference Woods NF, LaCroix AZ, Gray SL, Aragaki A, Cochrane BB, Brunner RL, et al. Women's Health Initiative. Frailty: emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study. J Am Geriatr Soc. 2005;53(8):1321–30.PubMedCrossRef Woods NF, LaCroix AZ, Gray SL, Aragaki A, Cochrane BB, Brunner RL, et al. Women's Health Initiative. Frailty: emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study. J Am Geriatr Soc. 2005;53(8):1321–30.PubMedCrossRef
28.
go back to reference Rockwood K, Mitnitski A, Song X, Steen B, Skoog I. Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70. J Am Geriatr Soc. 2006;54(6):975–9.PubMedCrossRef Rockwood K, Mitnitski A, Song X, Steen B, Skoog I. Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70. J Am Geriatr Soc. 2006;54(6):975–9.PubMedCrossRef
29.
go back to reference Song X, Mitnitski A, Rockwood K. Prevalence and 10-year outcomes of frailty in older adults in relation to deficit accumulation. J Am Geriatr Soc. 2010;58(4):681–7.PubMedCrossRef Song X, Mitnitski A, Rockwood K. Prevalence and 10-year outcomes of frailty in older adults in relation to deficit accumulation. J Am Geriatr Soc. 2010;58(4):681–7.PubMedCrossRef
30.••
go back to reference Robinson TN, Eiseman B, Wallace JI, Church SD, McFann KK, Pfister SM, et al. Redefining geriatric preoperative assessment using frailty, disability and co-morbidity. Ann Surg. 2009;250(3):449–55. Prospective study demonstrating that the accumulated deficit model of frailty, when measured in surgical patients requiring ICU care, is a reliable predictor of discharge to a nursing facility and mortality. Identifies important questions regarding the cost-effectiveness and appropriateness of pursuing surgical care in frail patients likely to need institutionalization or at high risk for mortality.PubMed Robinson TN, Eiseman B, Wallace JI, Church SD, McFann KK, Pfister SM, et al. Redefining geriatric preoperative assessment using frailty, disability and co-morbidity. Ann Surg. 2009;250(3):449–55. Prospective study demonstrating that the accumulated deficit model of frailty, when measured in surgical patients requiring ICU care, is a reliable predictor of discharge to a nursing facility and mortality. Identifies important questions regarding the cost-effectiveness and appropriateness of pursuing surgical care in frail patients likely to need institutionalization or at high risk for mortality.PubMed
31.
go back to reference Dasgupta M, Rolfson DB, Stolee P, Borrie MJ, Speechley M. Frailty is associated with postoperative complications in older adults with medical problems. Arch Gerontol Geriatr. 2009;48(1):78–83.PubMedCrossRef Dasgupta M, Rolfson DB, Stolee P, Borrie MJ, Speechley M. Frailty is associated with postoperative complications in older adults with medical problems. Arch Gerontol Geriatr. 2009;48(1):78–83.PubMedCrossRef
32.
go back to reference Velanovich V, Antoine H, Swartz A, Peters D, Rubinfeld I. Accumulating deficits model of frailty and postoperative mortality and morbidity: its application to a national database. J Surg Res. 2013;183(1):104–10.PubMedCrossRef Velanovich V, Antoine H, Swartz A, Peters D, Rubinfeld I. Accumulating deficits model of frailty and postoperative mortality and morbidity: its application to a national database. J Surg Res. 2013;183(1):104–10.PubMedCrossRef
33.••
go back to reference Makary MA, Segev DL, Pronovost PJ, Syin D, Bandeen-Roche K, Patel P, et al. Frailty as a predictor of surgical outcomes in older patients. J Am Coll Surg. 2010;210(6):901–8. This large, prospective study was the first to adapt Dr. Fried’s phenotypic frailty definition to a surgical cohort. Identification of the frailty syndrome was shown to be a reliable method for distinguishing patients at increased risk for post-operative complications, extended length of stay, discharge to a nursing facility, and mortality.PubMedCrossRef Makary MA, Segev DL, Pronovost PJ, Syin D, Bandeen-Roche K, Patel P, et al. Frailty as a predictor of surgical outcomes in older patients. J Am Coll Surg. 2010;210(6):901–8. This large, prospective study was the first to adapt Dr. Fried’s phenotypic frailty definition to a surgical cohort. Identification of the frailty syndrome was shown to be a reliable method for distinguishing patients at increased risk for post-operative complications, extended length of stay, discharge to a nursing facility, and mortality.PubMedCrossRef
34.
go back to reference Revenig LM, Canter DJ, Taylor MD, Tai C, Sweeney JF, Sarmiento JM, et al. Too frail for surgery? Initial results of a large multidisciplinary prospective study examining preoperative variables predictive of poor surgical outcomes. J Am Coll Surg. 2013;217(4):665–70.PubMedCrossRef Revenig LM, Canter DJ, Taylor MD, Tai C, Sweeney JF, Sarmiento JM, et al. Too frail for surgery? Initial results of a large multidisciplinary prospective study examining preoperative variables predictive of poor surgical outcomes. J Am Coll Surg. 2013;217(4):665–70.PubMedCrossRef
35.
go back to reference Revenig LM, Canter DJ, Master VA, Maithel SK, Kooby DA, Pattaras JG, et al. A prospective study examining the association between pre-operative frailty and post-operative complications in patients undergoing minimally invasive surgery. J Endourol. 2013. In press. Revenig LM, Canter DJ, Master VA, Maithel SK, Kooby DA, Pattaras JG, et al. A prospective study examining the association between pre-operative frailty and post-operative complications in patients undergoing minimally invasive surgery. J Endourol. 2013. In press.
36.
go back to reference Rockwood K, Song X, Mitnitski A. Changes in relative fitness and frailty across the adult lifespan: evidence from the Canadian National Population Health Survey. CMAJ. 2011;183(8):E487–94.PubMedCentralPubMedCrossRef Rockwood K, Song X, Mitnitski A. Changes in relative fitness and frailty across the adult lifespan: evidence from the Canadian National Population Health Survey. CMAJ. 2011;183(8):E487–94.PubMedCentralPubMedCrossRef
38.
go back to reference Steensma DP, Tefferi A. Anemia in the elderly: how should we define it, when does it matter, and what can be done? Mayo Clin Proc. 2007;82(8):958–66.PubMedCrossRef Steensma DP, Tefferi A. Anemia in the elderly: how should we define it, when does it matter, and what can be done? Mayo Clin Proc. 2007;82(8):958–66.PubMedCrossRef
39.
go back to reference Goodnough LT, Maniatis A, Earnshaw P, Benoni G, Beris P, Bisbe E, et al. Detection, evaluation, and management of preoperative anaemia in the elective orthopaedic surgical patient: NATA guidelines. Br J Anaesth. 2011;106(1):13–22.PubMedCrossRef Goodnough LT, Maniatis A, Earnshaw P, Benoni G, Beris P, Bisbe E, et al. Detection, evaluation, and management of preoperative anaemia in the elective orthopaedic surgical patient: NATA guidelines. Br J Anaesth. 2011;106(1):13–22.PubMedCrossRef
40.
go back to reference Waters DL, Baumgartner RN, Garry PJ, Vellas B. Advantages of dietary, exercise-related, and therapeutic interventions to prevent and treat sarcopenia in adult patients: an update. Clin Interv Aging. 2010;5:259–70.PubMedCentralPubMedCrossRef Waters DL, Baumgartner RN, Garry PJ, Vellas B. Advantages of dietary, exercise-related, and therapeutic interventions to prevent and treat sarcopenia in adult patients: an update. Clin Interv Aging. 2010;5:259–70.PubMedCentralPubMedCrossRef
41.
go back to reference Andersen HK, Lewis SJ, Thomas S. Early enteral nutrition within 24 h of colorectal surgery versus later commencement of feeding for postoperative complications. Cochrane Database Syst Rev. 2006. doi:10.1002/14651858.CD004080.pub2. Andersen HK, Lewis SJ, Thomas S. Early enteral nutrition within 24 h of colorectal surgery versus later commencement of feeding for postoperative complications. Cochrane Database Syst Rev. 2006. doi:10.​1002/​14651858.​CD004080.​pub2.
42.
go back to reference Lewis SJ, Andersen HK, Thomas S. Early enteral nutrition within 24 h of intestinal surgery versus later commencement of feeding: a systematic review and meta-analysis. J Gastrointest Surg. 2009;13(3):569–75.PubMedCrossRef Lewis SJ, Andersen HK, Thomas S. Early enteral nutrition within 24 h of intestinal surgery versus later commencement of feeding: a systematic review and meta-analysis. J Gastrointest Surg. 2009;13(3):569–75.PubMedCrossRef
43.
go back to reference Basse L, Raskov HH, Hjort Jakobsen D, Sonne E, Billesbølle P, Hendel HW, et al. Accelerated postoperative recovery programme after colonic resection improves physical performance, pulmonary function and body composition. Br J Surg. 2002;89(4):446–53.PubMedCrossRef Basse L, Raskov HH, Hjort Jakobsen D, Sonne E, Billesbølle P, Hendel HW, et al. Accelerated postoperative recovery programme after colonic resection improves physical performance, pulmonary function and body composition. Br J Surg. 2002;89(4):446–53.PubMedCrossRef
44.
go back to reference Karl A, Buchner A, Becker A, Staehler M, Seitz M, Khoder K, et al. A new concept for Early Recovery After Surgery in patients undergoing radical cystectomy for bladder cancer—results of a prospective randomized study. J Urol. 2013. doi:10.1016/j.juro.2013.08.019. Karl A, Buchner A, Becker A, Staehler M, Seitz M, Khoder K, et al. A new concept for Early Recovery After Surgery in patients undergoing radical cystectomy for bladder cancer—results of a prospective randomized study. J Urol. 2013. doi:10.​1016/​j.​juro.​2013.​08.​019.
45.
go back to reference Cadore EL, Rodríguez-Mañas L, Sinclair A, Izquierdo M. Effects of different exercise interventions on risk of falls, gait ability, and balance in physically frail older adults: a systematic review. Rejuvenation Res. 2013;16(2):105–14.PubMedCrossRef Cadore EL, Rodríguez-Mañas L, Sinclair A, Izquierdo M. Effects of different exercise interventions on risk of falls, gait ability, and balance in physically frail older adults: a systematic review. Rejuvenation Res. 2013;16(2):105–14.PubMedCrossRef
46.
go back to reference Thompson AR, Peters N, Lovegrove RE, Ledwidge S, Kitching A, Magee TR, et al. Cardiopulmonary exercise testing provides a predictive tool for early and late outcomes in abdominal aortic aneurysm patients. Ann R Coll Surg Engl. 2011;93(6):474–81.PubMedCentralPubMedCrossRef Thompson AR, Peters N, Lovegrove RE, Ledwidge S, Kitching A, Magee TR, et al. Cardiopulmonary exercise testing provides a predictive tool for early and late outcomes in abdominal aortic aneurysm patients. Ann R Coll Surg Engl. 2011;93(6):474–81.PubMedCentralPubMedCrossRef
47.
go back to reference Yeap BB, Araujo AB, Wittert GA. Do low testosterone levels contribute to ill-health during male ageing? Crit Rev Clin Lab Sci. 2012;49(5–6):168–82.PubMedCrossRef Yeap BB, Araujo AB, Wittert GA. Do low testosterone levels contribute to ill-health during male ageing? Crit Rev Clin Lab Sci. 2012;49(5–6):168–82.PubMedCrossRef
48.
go back to reference Laosa O, Alonso C, Castro M, Rodríguez-Mañas L. Pharmaceutical interventions for frailty and sarcopenia. Curr Pharm Des. 2013;PMID:24079768. Laosa O, Alonso C, Castro M, Rodríguez-Mañas L. Pharmaceutical interventions for frailty and sarcopenia. Curr Pharm Des. 2013;PMID:24079768.
49.
go back to reference Strollo F, Strollo G, Morè M, Magni P, Macchi C, Masini MA, et al. Low-intermediate dose testosterone replacement therapy by different pharmaceutical preparations improves frailty score in elderly hypogonadal hyperglycaemic patients. Aging Male. 2013;16(2):33–7.PubMedCrossRef Strollo F, Strollo G, Morè M, Magni P, Macchi C, Masini MA, et al. Low-intermediate dose testosterone replacement therapy by different pharmaceutical preparations improves frailty score in elderly hypogonadal hyperglycaemic patients. Aging Male. 2013;16(2):33–7.PubMedCrossRef
50.
go back to reference Lee DH, Buth KJ, Martin BJ, Yip AM, Hirsch GM. Frail patients are at increased risk for mortality and prolonged institutional care after cardiac surgery. Circulation. 2010;121(8):973–8.PubMedCrossRef Lee DH, Buth KJ, Martin BJ, Yip AM, Hirsch GM. Frail patients are at increased risk for mortality and prolonged institutional care after cardiac surgery. Circulation. 2010;121(8):973–8.PubMedCrossRef
51.
go back to reference Robinson TN, Wallace JI, Wu DS, Wiktor A, Pointer LF, Pfister SM, et al. Accumulated frailty characteristics predict postoperative discharge institutionalization in the geriatric patient. J Am Coll Surg. 2011;213(1):37–42.PubMedCentralPubMedCrossRef Robinson TN, Wallace JI, Wu DS, Wiktor A, Pointer LF, Pfister SM, et al. Accumulated frailty characteristics predict postoperative discharge institutionalization in the geriatric patient. J Am Coll Surg. 2011;213(1):37–42.PubMedCentralPubMedCrossRef
52.
go back to reference Tan KY, Kawamura YJ, Tokomitsu A, Tang T. Assessment for frailty is useful for predicting morbidity in elderly patients undergoing colorectal cancer resection whose comorbidities are already optimized. Am J Surg. 2012;204(2):139–43.PubMedCrossRef Tan KY, Kawamura YJ, Tokomitsu A, Tang T. Assessment for frailty is useful for predicting morbidity in elderly patients undergoing colorectal cancer resection whose comorbidities are already optimized. Am J Surg. 2012;204(2):139–43.PubMedCrossRef
53.
go back to reference Courtney-Brooks M, Tellawi AR, Scalici J, Duska LR, Jazaeri AA, Modesitt SC, et al. Frailty: an outcome predictor for elderly gynecologic oncology patients. Gynecol Oncol. 2012;126(1):20–4.PubMedCrossRef Courtney-Brooks M, Tellawi AR, Scalici J, Duska LR, Jazaeri AA, Modesitt SC, et al. Frailty: an outcome predictor for elderly gynecologic oncology patients. Gynecol Oncol. 2012;126(1):20–4.PubMedCrossRef
Metadata
Title
The Use of Frailty as a Surgical Risk Assessment Tool in Elderly Patients
Authors
Louis M. Revenig
Kenneth Ogan
Thomas J. Guzzo
Daniel J. Canter
Publication date
01-03-2014
Publisher
Springer US
Published in
Current Geriatrics Reports / Issue 1/2014
Electronic ISSN: 2196-7865
DOI
https://doi.org/10.1007/s13670-013-0068-z

Other articles of this Issue 1/2014

Current Geriatrics Reports 1/2014 Go to the issue

Geriatric Urology (TJ Guzzo and DJ Canter, Section Editors)

The Prevalence and Treatment of Voiding Dysfunction in the Elderly

Geriatric Urology (TJ Guzzo and DJ Canter, Section Editors)

Renal Cell Carcinoma: Management in the Elderly

Infectious Diseases in the Elderly (SF Bradley, Section Editor)

Vaccinations for Older Adults: An Update

Geriatric Urology (TJ Guzzo and DJ Canter, Section Editors)

Stones in the Elderly

Geriatric Urology (TJ Guzzo and DJ Canter, Section Editors)

Non-Muscle-Invasive Bladder Cancer in the Elderly Patient

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine