Published in:
25-10-2021 | Gestational Diabetes | Original Article
Correlation analysis of triglycerides to high-density lipoprotein-cholesterol ratio associated with gestational diabetes mellitus
Published in: International Journal of Diabetes in Developing Countries | Issue 4/2022
Login to get accessAbstract
Background
Gestational diabetes mellitus (GDM) initiates when a woman’s pancreas could not act appropriately to bypass the diabetogenic condition during pregnancy. It is increasing across the world, including Bangladesh. Triglycerides (TG) and high-density lipoprotein-cholesterol (HDLC) are strongly connected with insulin resistance in pregnant women.
Objectives
Observation of the role of lipid profiles and TG/HDL cholesterol ratio associated with fasting glucose in GDM subjects.
Methods
In this experiment, a total of 232 individual subjects consisting of 132 GDM-positive and 100 GDM-negative pregnant women were examined and observed from 24 to 28 weeks of their pregnancy period. For this study, we had collected blood samples from selected women before and after breakfast and analyzed blood glucose level, triglyceride cholesterol level, HDL, low-density lipoprotein (LDL), and TG/HDL ratio.
Results
TG and LDL-cholesterol were significantly higher (p < 0.001) in GDM individuals (220.95 ± 67.4 and 149.54 ± 32.4, respectively) than those of the non-GDM (160.98 ± 59.67 and 129.18 ± 34.18, respectively). On the contrary, HDL-cholesterol level was comparatively lower in GDM-positive women than non-GDM subjects. In this case, the optimum cut-off point was 3.8 for the TG/HDL-C ratio with 62% sensitivity and 78% specificity by oral glucose tolerance test (OGTT).
Conclusion
Significantly (p < 0.001) higher TG/HDL ratio was found in GDM women compared with those in non‐GDM. TG/HDL ratios are independently associated with the risks of GDM, which might be a good marker in predicting GDM risk.