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01-02-2015

No association between Apoε4 alleles, HIV infection, age, neuropsychological outcome, or death

Authors: James T. Becker, Jeremy J. Martinson, Sudhir Penugonda, Lawrence Kingsley, Samantha Molsberry, Sandra Reynolds, Aaron Aronow, Karl Goodkin, Andrew Levine, Eileen Martin, Eric N. Miller, Cynthia A. Munro, Ann Ragin, Ned Sacktor

Published in: Journal of NeuroVirology | Issue 1/2015

Abstract

The ε4 allele of the apolipoprotein E (ApoE) gene may have important interactions with physical health and cognitive function among individuals with HIV disease. The purpose of this study is to examine the relationships between ε4, HIV disease, age, neuropsychological impairment, and death in a large, well-characterized study sample. A total of 2846 men participating in the Multicenter AIDS Cohort Study had ApoE genotyping and neuropsychological test data available for analysis. We found a significant association between HIV infection and time to death (from any cause), as well as older age, race, and education. But, ApoE status was not significantly associated with time to death. Similarly, we found a significant association between HIV infection and time to incident cognitive impairment, as well as age, education, and HIV serostatus; Apoε4 status was not related to incident cognitive impairment. There were no significant interactions between ApoE, HIV infection, and age on cognitive impairment. These data replicate and strengthen prior findings of the lack of association between ApoE ε4 and cognitive outcomes in HIV disease. We conclude that within the specific constraints of an exclusively male study in which the majority of participants were less than 65 years of age (range 22–87 years), it appears reasonable to conclude that the ε4 allele is not significantly interacting with HIV serostatus.

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Title: No association between Apoε4 alleles, HIV infection, age, neuropsychological outcome, or death
Authors: James T. Becker
Jeremy J. Martinson
Sudhir Penugonda
Lawrence Kingsley
Samantha Molsberry
Sandra Reynolds
Aaron Aronow
Karl Goodkin
Andrew Levine
Eileen Martin
Eric N. Miller
Cynthia A. Munro
Ann Ragin
Ned Sacktor
Publication date: 01-02-2015
Publisher: Springer US
Published in: Journal of NeuroVirology / Issue 1/2015
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-014-0290-2

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No association between Apoε4 alleles, HIV infection, age, neuropsychological outcome, or death

Abstract

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Abstract

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