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01-08-2013 | Case Report

CSF viral escape in a patient with HIV-associated neurocognitive disorder

Authors: Michael N. Khoury, C. Sabrina Tan, Marcia Peaslee, Igor J. Koralnik

Published in: Journal of NeuroVirology | Issue 4/2013

Excerpt

HIV-associated neurocognitive disorder (HAND) is a condition that encompasses cognitive deficits as well as motor symptoms. HIV is thought to enter the CNS early at the time of primary infection by crossing the blood brain barrier. The virus primarily infects perivascular macrophages and microglia (both of which express CD4); while the neurons, which do not express CD4, sustain injury secondary to the resulting inflammation (Gonzalez-Scarano and Martin-Garcia 2005). HAND MRI findings classically include symmetric, periventricular hyperintense lesions on T2-weighted sequences. …

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Title: CSF viral escape in a patient with HIV-associated neurocognitive disorder
Authors: Michael N. Khoury
C. Sabrina Tan
Marcia Peaslee
Igor J. Koralnik
Publication date: 01-08-2013
Publisher: Springer US
Published in: Journal of NeuroVirology / Issue 4/2013
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-013-0175-9

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CSF viral escape in a patient with HIV-associated neurocognitive disorder

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