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European Journal of Drug Metabolism and Pharmacokinetics

Published in:

01-06-2014 | Original Paper

Pharmacokinetic interaction studies of fenugreek with CYP3A substrates cyclosporine and carbamazepine

Authors: Fahad I. Al-Jenoobi, Mohd Aftab Alam, Khalid M. Alkharfy, Saleh A. Al-Suwayeh, Hesham M. Korashy, Abdullah M. Al-Mohizea, Muzaffar Iqbal, Abdul Ahad, Mohammad Raish

Published in: European Journal of Drug Metabolism and Pharmacokinetics | Issue 2/2014

Abstract

The present study investigated the effect of fenugreek seed powder on disposition of CYP3A substrates, cyclosporine and carbamazepine. Rabbits were treated with fenugreek seed powder (300 mg/kg p.o.) for 8 days and on 8th day the single dose of cyclosporine (30 mg/kg, p.o.) and carbamazepine (40 mg/kg, p.o.) were administered to the corresponding group after 1 h of fenugreek administration. Blood samples were drawn at several time points and analyzed by using UPLC-MS (cyclosporine) and HPLC (carbamazepine). Pharmacokinetic parameters were calculated by using PKSolver. The present investigation reveals that there was no statistically significant difference between pre- and post-treated pharmacokinetic parameters such as AUC_0–t, AUC_0–∞, C _max, T _max, T _1/2, K _el, MRT_0–∞, V _z/F, and Cl/F for cyclosporine and carbamazepine. Two tailed “P” values for all these pharmacokinetic parameters were more than 0.05, indicating insignificant impact of fenugreek treatment on the disposition of cyclosporine and carbamazepine. Further, fenugreek may also not have any significant effect on the functionality of P-glycoprotein as cyclosporine is a substrate to P-glycoprotein. The outcomes of present study suggested that fenugreek may not likely to interfere cyclosporine and carbamazepine pharmacokinetics, when co-administered with these drugs.

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Title: Pharmacokinetic interaction studies of fenugreek with CYP3A substrates cyclosporine and carbamazepine
Authors: Fahad I. Al-Jenoobi
Mohd Aftab Alam
Khalid M. Alkharfy
Saleh A. Al-Suwayeh
Hesham M. Korashy
Abdullah M. Al-Mohizea
Muzaffar Iqbal
Abdul Ahad
Mohammad Raish
Publication date: 01-06-2014
Publisher: Springer International Publishing
Published in: European Journal of Drug Metabolism and Pharmacokinetics / Issue 2/2014
Print ISSN: 0378-7966
Electronic ISSN: 2107-0180
DOI: https://doi.org/10.1007/s13318-013-0149-6

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Pharmacokinetic interaction studies of fenugreek with CYP3A substrates cyclosporine and carbamazepine

Abstract

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