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Neurotherapeutics
Published in: Neurotherapeutics 2/2011

01-04-2011 | Review

Hypothermic Treatment for Acute Spinal Cord Injury

Authors: W. Dalton Dietrich, Allan D. Levi, Michael Wang, Barth A. Green

Published in: Neurotherapeutics | Issue 2/2011

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Summary

Spinal cord injury (SCI) is a devastating condition that affects approximately 11,000 patients each year in the United States. Although a significant amount of research has been conducted to clarify the pathophysiology of SCI, there are limited therapeutic interventions that are currently available in the clinic. Moderate hypothermia has been used in a variety of experimental and clinical situations to target several neurological disorders, including traumatic brain and SCI. Recent studies using clinically relevant animal models of SCI have reported the efficacy of therapeutic hypothermia (TH) in terms of promoting long-term behavioral improvement and reducing histopathological damage. In addition, several clinical studies have demonstrated encouraging evidence for the use of TH in patients with a severe cervical spinal cord injury. Moderate hypothermia (33°C) introduced systemically by intravascular cooling strategies appears to be safe and provides some improvement of long-term recovery of function. TH remains an experimental clinical approach and randomized multicenter trials are needed to critically evaluate this potentially exciting therapeutic intervention targeting this patient population.
Appendix
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Metadata
Title
Hypothermic Treatment for Acute Spinal Cord Injury
Authors
W. Dalton Dietrich
Allan D. Levi
Michael Wang
Barth A. Green
Publication date
01-04-2011
Publisher
Springer-Verlag
Published in
Neurotherapeutics / Issue 2/2011
Print ISSN: 1933-7213
Electronic ISSN: 1878-7479
DOI
https://doi.org/10.1007/s13311-011-0035-3

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