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01-09-2017 | Review Article

Meta-analysis of laparoscopic vs open liver resection for hepatocellular carcinoma

Authors: Georgios C. Sotiropoulos, Anastasia Prodromidou, Ioannis D. Kostakis, Nikolaos Machairas

Published in: Updates in Surgery | Issue 3/2017

Abstract

Laparoscopic liver resections (LLR) are widely accepted as safe and effective procedures for the management of hepatocellular carcinoma (HCC) in the hands of experienced surgeons. The efficacy and extent of benefits of pure as well as hand-assisted laparoscopic and laparoscopy-assisted liver resection over open liver resection (OLR) have been investigated by numerous studies during the last 10 years. The aim of our meta-analysis is to investigate the effect of LLR in short- and long-term outcomes compared to OLR in patients operated for HCC. A total of 5203 patients from forty-four studies were included in our meta-analysis reporting for short- and long-term results for both LLR and OLR for HCC. Among them, 1830 underwent pure laparoscopic hepatectomy, 282 underwent pure laparoscopic or hand-assisted laparoscopic or laparoscopy-assisted hepatectomy, and 3091 were operated through open approach. LLRs were found to be significantly associated with lower blood loss, need for blood transfusion, successful achievement of R0 resection as well as wider resection margin, shorter hospital stay, lower morbidity and 30-day mortality rates. Operative time, tumor recurrence, 1-, 3-, and 5-year overall survival as well as 1-, 3-, and 5-year disease-free survival were not found different between the groups. This meta-analysis clearly demonstrates the superiority of laparoscopic resection over the open approach for patients with small HCC.

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Title: Meta-analysis of laparoscopic vs open liver resection for hepatocellular carcinoma
Authors: Georgios C. Sotiropoulos
Anastasia Prodromidou
Ioannis D. Kostakis
Nikolaos Machairas
Publication date: 01-09-2017
Publisher: Springer Milan
Published in: Updates in Surgery / Issue 3/2017
Print ISSN: 2038-131X
Electronic ISSN: 2038-3312
DOI: https://doi.org/10.1007/s13304-017-0421-4

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Meta-analysis of laparoscopic vs open liver resection for hepatocellular carcinoma

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