Skip to main content
Top
Published in: Updates in Surgery 1/2013

01-03-2013 | Original Article

Management of distal rectal cancer: results from a national survey

Authors: G. Melotti, E. De Antoni, A. Habr-Gama, A. Minicozzi

Published in: Updates in Surgery | Issue 1/2013

Login to get access

Abstract

Owing to the complexity of distal rectal cancer its management requires a multidisciplinary approach. The diagnosis and the response after neoadjuvant chemoradiotherapy are not easy to assess and therefore the surgical approach is heterogeneous. The purpose of this survey is to evaluate the experiences of members of the Italian Society of Surgery in diagnosis and treatment strategies for rectal cancer and compare it with international practice. A questionnaire was devised comprising 18 questions with 11 sub-items making a total of 29 questions and submitted online to all the 2,500 members of the SIC starting from July 2010. The survey was completed in June 2011. The overall response rate was 17.8 % (444). The majority of the Italian surgeons’ responses were in line with the international consensus reflecting the complex management of distal rectal cancer. Other opinions, especially those on staging, diverge from the common view of MRI being the gold standard in the assessment of loco-regional diffusion of the disease and on the superiority of FDG PET-CT versus CT for systemic staging. The timing for the re-staging and for surgery following neoadjuvant chemoradiotherapy does not reflect the international opinion. Italian surgeons are also exposed to the common difficulties encountered internationally in the management of distal rectal cancer. Probably, the implementation of an Italian rectal cancer registry and of many national and international multicentre studies may improve the management of rectal cancer in Italy.
Literature
1.
go back to reference Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. Cancer J Clin 61(2):69–90 Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. Cancer J Clin 61(2):69–90
2.
go back to reference Grassetto G, Marzola MC, Minicozzi A, Al-Nahhas A, Rubello D (2011) F-18 FDG PET/CT in rectal carcinoma: where are we now? Clin Nucl Med 36(10):884–888 (Review)PubMedCrossRef Grassetto G, Marzola MC, Minicozzi A, Al-Nahhas A, Rubello D (2011) F-18 FDG PET/CT in rectal carcinoma: where are we now? Clin Nucl Med 36(10):884–888 (Review)PubMedCrossRef
3.
go back to reference Murad-Regadas SM, Regadas FS, Rodrigues LV, Crispin FJ, Kenmoti VT, Fernandes GO, Buchen G, Monteiro FC (2011) Criteria for three-dimensional anorectal ultrasound assessment of response to chemoradiotherapy in rectal cancer patients. Colorectal Dis 13(12):1344–1354PubMedCrossRef Murad-Regadas SM, Regadas FS, Rodrigues LV, Crispin FJ, Kenmoti VT, Fernandes GO, Buchen G, Monteiro FC (2011) Criteria for three-dimensional anorectal ultrasound assessment of response to chemoradiotherapy in rectal cancer patients. Colorectal Dis 13(12):1344–1354PubMedCrossRef
4.
go back to reference Kundel Y, Brenner R, Purim O, Peled N, Idelevich E, Fenig E, Sulkes A, Brenner B (2010) Is local excision after complete pathological response to neoadjuvant chemoradiation for rectal cancer an acceptable treatment option? Dis Colon Rectum 53(12):1624–1631PubMedCrossRef Kundel Y, Brenner R, Purim O, Peled N, Idelevich E, Fenig E, Sulkes A, Brenner B (2010) Is local excision after complete pathological response to neoadjuvant chemoradiation for rectal cancer an acceptable treatment option? Dis Colon Rectum 53(12):1624–1631PubMedCrossRef
5.
go back to reference Habr-Gama A, Perez RO, São Julião GP, Proscurshim I, Gama-Rodrigues J (2011) The need for effective radiosentitizing agents: experience in patients with complete pathological response. Anticancer Drugs 22(4):308–310 (Review)PubMedCrossRef Habr-Gama A, Perez RO, São Julião GP, Proscurshim I, Gama-Rodrigues J (2011) The need for effective radiosentitizing agents: experience in patients with complete pathological response. Anticancer Drugs 22(4):308–310 (Review)PubMedCrossRef
6.
go back to reference Gerard JP, Rostom Y, Gal J, Benchimol D, Ortholan C, Aschele C, Levi JM (2012) Can we increase the chance of sphincter saving surgery in rectal cancer with neoadjuvant treatments: lessons from a systematic review of recent randomized trials. Crit Rev Oncol Hematol 81(1):21–28 [Epub 2011 Mar 5]PubMedCrossRef Gerard JP, Rostom Y, Gal J, Benchimol D, Ortholan C, Aschele C, Levi JM (2012) Can we increase the chance of sphincter saving surgery in rectal cancer with neoadjuvant treatments: lessons from a systematic review of recent randomized trials. Crit Rev Oncol Hematol 81(1):21–28 [Epub 2011 Mar 5]PubMedCrossRef
7.
go back to reference Habr-Gama A, Perez RO, São Julião GP, Proscurshim I, Nahas SC, Gama-Rodrigues J (2011) Factors affecting management decisions in rectal cancer in clinical practice: results from a national survey. Tech Coloproctol 15(1):45–51 [Epub 2010 Nov 6]PubMedCrossRef Habr-Gama A, Perez RO, São Julião GP, Proscurshim I, Nahas SC, Gama-Rodrigues J (2011) Factors affecting management decisions in rectal cancer in clinical practice: results from a national survey. Tech Coloproctol 15(1):45–51 [Epub 2010 Nov 6]PubMedCrossRef
8.
go back to reference Wynn GR, Bhasin N, Macklin CP, George ML (2010) Complete clinical response to neoadjuvant chemoradiotherapy in patients with rectal cancer: opinions of British and Irish specialists. Colorectal Dis 12(4):327–333 [Epub 2009 Jun 25]PubMedCrossRef Wynn GR, Bhasin N, Macklin CP, George ML (2010) Complete clinical response to neoadjuvant chemoradiotherapy in patients with rectal cancer: opinions of British and Irish specialists. Colorectal Dis 12(4):327–333 [Epub 2009 Jun 25]PubMedCrossRef
9.
go back to reference Augestad KM, Lindsetmo RO, Reynolds H, Stulberg J, Senagore A, Champagne B, Heriot AG, Leblanc F, Delaney CP (2011) International trends in surgical treatment of rectal cancer. Am J Surg 201(3):353–357 (discussion 357-8)PubMedCrossRef Augestad KM, Lindsetmo RO, Reynolds H, Stulberg J, Senagore A, Champagne B, Heriot AG, Leblanc F, Delaney CP (2011) International trends in surgical treatment of rectal cancer. Am J Surg 201(3):353–357 (discussion 357-8)PubMedCrossRef
10.
go back to reference Gagliardi G, Pucciarelli S, Asteria CR, Infantino A, Romano G, Cola B, De Nardi P, Brulatti M, Lambertini M, Contessini-Avesani E, Casula G, Coco C, D’Amico D, Selvaggi FF, Eccher C, D’Ambrosio G, Galeotti F, Jovine E, Demma I, Fianchini A, Ambrosino G, Casentino LM, Fiorino M (2010) A nationwide audit of the use of radiotherapy for rectal cancer in Italy. Tech Coloproctol 14(3):229–235 [Epub 2010 Jul 15]PubMedCrossRef Gagliardi G, Pucciarelli S, Asteria CR, Infantino A, Romano G, Cola B, De Nardi P, Brulatti M, Lambertini M, Contessini-Avesani E, Casula G, Coco C, D’Amico D, Selvaggi FF, Eccher C, D’Ambrosio G, Galeotti F, Jovine E, Demma I, Fianchini A, Ambrosino G, Casentino LM, Fiorino M (2010) A nationwide audit of the use of radiotherapy for rectal cancer in Italy. Tech Coloproctol 14(3):229–235 [Epub 2010 Jul 15]PubMedCrossRef
11.
go back to reference Nugent E, Neary P (2010) Rectal cancer surgery: volume-outcome analysis. Int J Colorectal Dis 25(12):1389–1396 [Epub 2010 Jul 27, Review]PubMedCrossRef Nugent E, Neary P (2010) Rectal cancer surgery: volume-outcome analysis. Int J Colorectal Dis 25(12):1389–1396 [Epub 2010 Jul 27, Review]PubMedCrossRef
12.
go back to reference Taylor F, Mangat N, Swift IR, Brown G (2010) Proforma-based reporting in rectal cancer. Cancer Imaging 10 Spec no A:S142–S150PubMedCrossRef Taylor F, Mangat N, Swift IR, Brown G (2010) Proforma-based reporting in rectal cancer. Cancer Imaging 10 Spec no A:S142–S150PubMedCrossRef
13.
go back to reference Beets-Tan RG, Beets GL, Vliegen RF, Kessels AG, Van Boven H, De Bruine A, von Meyenfeldt MF, Baeten CG, van Engelshoven JM (2001) Accuracy of magnetic resonance imaging in prediction of tumour-free resection margin in rectal cancer surgery. Lancet 357(9255):497–504PubMedCrossRef Beets-Tan RG, Beets GL, Vliegen RF, Kessels AG, Van Boven H, De Bruine A, von Meyenfeldt MF, Baeten CG, van Engelshoven JM (2001) Accuracy of magnetic resonance imaging in prediction of tumour-free resection margin in rectal cancer surgery. Lancet 357(9255):497–504PubMedCrossRef
14.
go back to reference Bamba Y, Itabashi M, Kameoka S (2012) Preoperative evaluation of the depth of anal canal invasion in very low rectal cancer by magnetic resonance imaging and surgical indications for intersphincteric resection. Surg Today 42(4):328–333 [Epub 2011 Nov 11]PubMedCrossRef Bamba Y, Itabashi M, Kameoka S (2012) Preoperative evaluation of the depth of anal canal invasion in very low rectal cancer by magnetic resonance imaging and surgical indications for intersphincteric resection. Surg Today 42(4):328–333 [Epub 2011 Nov 11]PubMedCrossRef
15.
go back to reference Capirci C, Rubello D, Pasini F, Galeotti F, Bianchini E, Del Favero G, Panzavolta R, Crepaldi G, Rampin L, Facci E, Gava M, Banti E, Marano G (2009) The role of dual-time combined 18-fluorodeoxyglucose positron emission tomography and computed tomography in the staging and restaging workup of locally advanced rectal cancer, treated with preoperative chemoradiation therapy and radical surgery. Int J Radiat Oncol Biol Phys 74(5):1461–1469 [Epub 2009 May 4]PubMedCrossRef Capirci C, Rubello D, Pasini F, Galeotti F, Bianchini E, Del Favero G, Panzavolta R, Crepaldi G, Rampin L, Facci E, Gava M, Banti E, Marano G (2009) The role of dual-time combined 18-fluorodeoxyglucose positron emission tomography and computed tomography in the staging and restaging workup of locally advanced rectal cancer, treated with preoperative chemoradiation therapy and radical surgery. Int J Radiat Oncol Biol Phys 74(5):1461–1469 [Epub 2009 May 4]PubMedCrossRef
16.
go back to reference Guillem JG, Moore HG, Akhurst T, Klimstra DS, Ruo L, Mazumdar M, Minsky BD, Saltz L, Wong WD, Larson S (2004) Sequential preoperative fluorodeoxyglucose-positron emission tomography assessment of response to preoperative chemoradiation: a means for determining longterm outcomes of rectal cancer. J Am Coll Surg 199(1):1–7PubMedCrossRef Guillem JG, Moore HG, Akhurst T, Klimstra DS, Ruo L, Mazumdar M, Minsky BD, Saltz L, Wong WD, Larson S (2004) Sequential preoperative fluorodeoxyglucose-positron emission tomography assessment of response to preoperative chemoradiation: a means for determining longterm outcomes of rectal cancer. J Am Coll Surg 199(1):1–7PubMedCrossRef
17.
go back to reference Janssen MH, Öllers MC, van Stiphout RG, Riedl RG, van den Bogaard J, Buijsen J, Lambin P, Lammering G (2012) PET-based treatment response evaluation in rectal cancer: prediction and validation. Int J Radiat Oncol Biol Phys 82(2):871–876 [Epub 2011 Mar 5]PubMedCrossRef Janssen MH, Öllers MC, van Stiphout RG, Riedl RG, van den Bogaard J, Buijsen J, Lambin P, Lammering G (2012) PET-based treatment response evaluation in rectal cancer: prediction and validation. Int J Radiat Oncol Biol Phys 82(2):871–876 [Epub 2011 Mar 5]PubMedCrossRef
18.
go back to reference Shihab OC, Quirke P, Heald RJ, Moran BJ, Brown G (2010) Magnetic resonance imaging-detected lymph nodes close to the mesorectal fascia are rarely a cause of margin involvement after total mesorectal excision. Br J Surg 97(9):1431–1436PubMedCrossRef Shihab OC, Quirke P, Heald RJ, Moran BJ, Brown G (2010) Magnetic resonance imaging-detected lymph nodes close to the mesorectal fascia are rarely a cause of margin involvement after total mesorectal excision. Br J Surg 97(9):1431–1436PubMedCrossRef
19.
go back to reference Heriot AG, Hicks RJ, Drummond EG, Keck J, Mackay J, Chen F, Kalff V (2004) Does positron emission tomography change management in primary rectal cancer? A prospective assessment. Dis Colon Rectum 47(4):451–458 [Epub 2004 Feb 25]PubMedCrossRef Heriot AG, Hicks RJ, Drummond EG, Keck J, Mackay J, Chen F, Kalff V (2004) Does positron emission tomography change management in primary rectal cancer? A prospective assessment. Dis Colon Rectum 47(4):451–458 [Epub 2004 Feb 25]PubMedCrossRef
20.
go back to reference Gearhart SL, Frassica D, Rosen R, Choti M, Schulick R, Wahl R (2006) Improved staging with pretreatment positron emission tomography/computed tomography in low rectal cancer. Ann Surg Oncol 13(3):397–404 [Epub 2006 Jan 30]PubMedCrossRef Gearhart SL, Frassica D, Rosen R, Choti M, Schulick R, Wahl R (2006) Improved staging with pretreatment positron emission tomography/computed tomography in low rectal cancer. Ann Surg Oncol 13(3):397–404 [Epub 2006 Jan 30]PubMedCrossRef
21.
go back to reference Lambregts DM, Maas M, Bakers FC, Cappendijk VC, Lammering G, Beets GL, Beets-Tan RG (2011) Long-term follow-up features on rectal MRI during a wait-and-see approach after a clinical complete response in patients with rectal cancer treated with chemoradiotherapy. Dis Colon Rectum 54(12):1521–1528PubMedCrossRef Lambregts DM, Maas M, Bakers FC, Cappendijk VC, Lammering G, Beets GL, Beets-Tan RG (2011) Long-term follow-up features on rectal MRI during a wait-and-see approach after a clinical complete response in patients with rectal cancer treated with chemoradiotherapy. Dis Colon Rectum 54(12):1521–1528PubMedCrossRef
22.
go back to reference Lambregts DM, Vandecaveye V, Barbaro B, Bakers FC, Lambrecht M, Maas M, Haustermans K, Valentini V, Beets GL, Beets-Tan RG (2011) Diffusion-weighted MRI for selection of complete responders after chemoradiation for locally advanced rectal cancer: a multicenter study. Ann Surg Oncol 18(8):2224–2231 [Epub 2011 Feb 23]PubMedCrossRef Lambregts DM, Vandecaveye V, Barbaro B, Bakers FC, Lambrecht M, Maas M, Haustermans K, Valentini V, Beets GL, Beets-Tan RG (2011) Diffusion-weighted MRI for selection of complete responders after chemoradiation for locally advanced rectal cancer: a multicenter study. Ann Surg Oncol 18(8):2224–2231 [Epub 2011 Feb 23]PubMedCrossRef
23.
go back to reference Perez RO, Habr-Gama A, Gama-Rodrigues J, Proscurshim I, Julião GP, Lynn P, Ono CR, Campos FG, Silva E Sousa AH Jr Md, Imperiale AR, Nahas SC, Buchpiguel CA (2012) Accuracy of positron emission tomography/computed tomography and clinical assessment in the detection of complete rectal tumor regression after neoadjuvant chemoradiation: long-term results of a prospective trial (National Clinical Trial 00254683). Cancer 118(14):3501–3511 Perez RO, Habr-Gama A, Gama-Rodrigues J, Proscurshim I, Julião GP, Lynn P, Ono CR, Campos FG, Silva E Sousa AH Jr Md, Imperiale AR, Nahas SC, Buchpiguel CA (2012) Accuracy of positron emission tomography/computed tomography and clinical assessment in the detection of complete rectal tumor regression after neoadjuvant chemoradiation: long-term results of a prospective trial (National Clinical Trial 00254683). Cancer 118(14):3501–3511
24.
go back to reference Martellucci J, Scheiterle M, Lorenzi B, Roviello F, Cetta F, Pinto E, Tanzini G (2012) Accuracy of transrectal ultrasound after preoperative radiochemotherapy compared to computed tomography and magnetic resonance in locally advanced rectal cancer. Int J Colorectal Dis 27(7):967–973 Martellucci J, Scheiterle M, Lorenzi B, Roviello F, Cetta F, Pinto E, Tanzini G (2012) Accuracy of transrectal ultrasound after preoperative radiochemotherapy compared to computed tomography and magnetic resonance in locally advanced rectal cancer. Int J Colorectal Dis 27(7):967–973
25.
go back to reference Guillem JG, Chessin DB, Shia J, Moore HG, Mazumdar M, Bernard B, Paty PB, Saltz L, Minsky BD, Weiser MR, Temple LK, Cohen AM, Wong WD (2005) Clinical examination following preoperative chemoradiation for rectal cancer is not a reliable surrogate end point. J Clin Oncol 23(15):3475–3479PubMedCrossRef Guillem JG, Chessin DB, Shia J, Moore HG, Mazumdar M, Bernard B, Paty PB, Saltz L, Minsky BD, Weiser MR, Temple LK, Cohen AM, Wong WD (2005) Clinical examination following preoperative chemoradiation for rectal cancer is not a reliable surrogate end point. J Clin Oncol 23(15):3475–3479PubMedCrossRef
26.
go back to reference Kuo LJ, Chiou JF, Tai CJ, Chang CC, Kung CH, Lin SE, Hung CS, Wang W, Tam KW, Lee HC, Liang HH, Chang YJ, Wei PL (2011) Can we predict pathologic complete response before surgery for locally advanced rectal cancer treated with preoperative chemoradiation therapy? Int J Colorectal Dis [Epub ahead of print] Kuo LJ, Chiou JF, Tai CJ, Chang CC, Kung CH, Lin SE, Hung CS, Wang W, Tam KW, Lee HC, Liang HH, Chang YJ, Wei PL (2011) Can we predict pathologic complete response before surgery for locally advanced rectal cancer treated with preoperative chemoradiation therapy? Int J Colorectal Dis [Epub ahead of print]
27.
go back to reference Habr-Gama A, Perez RO, Wynn G, Marks J, Kessler H, Gama-Rodrigues J (2010) Complete clinical response after neoadjuvant chemoradiation therapy for distal rectal cancer: characterization of clinical and endoscopic findings for standardization. Dis Colon Rectum 53(12):1692–1698PubMedCrossRef Habr-Gama A, Perez RO, Wynn G, Marks J, Kessler H, Gama-Rodrigues J (2010) Complete clinical response after neoadjuvant chemoradiation therapy for distal rectal cancer: characterization of clinical and endoscopic findings for standardization. Dis Colon Rectum 53(12):1692–1698PubMedCrossRef
28.
go back to reference Smith FM, Chang KH, Sheahan K, Hyland J, O’Connell PR, Winter DC (2012) The surgical significance of residual mucosal abnormalities in rectal cancer following neoadjuvant chemoradiotherapy. Br J Surg. doi:10.1002/bjs.8700 [Epub ahead of print] Smith FM, Chang KH, Sheahan K, Hyland J, O’Connell PR, Winter DC (2012) The surgical significance of residual mucosal abnormalities in rectal cancer following neoadjuvant chemoradiotherapy. Br J Surg. doi:10.​1002/​bjs.​8700 [Epub ahead of print]
29.
go back to reference Bökkerink GM, de Graaf EJ, Punt CJ, Nagtegaal ID, Rütten H, Nuyttens JJ, van Meerten E, Doornebosch PG, Tanis PJ, Derksen EJ, Dwarkasing RS, Marijnen CA, Cats A, Tollenaar RA, de Hingh IH, Rutten HJ, van der Schelling GP, Ten Tije AJ, Leijtens JW, Lammering G, Beets GL, Aufenacker TJ, Pronk A, Manusama ER, Hoff C, Bremers AJ, Verhoef C, de Wilt JH (2011) The CARTS study: Chemoradiation therapy for rectal cancer in the distal rectum followed by organ-sparing transanal endoscopic microsurgery. BMC Surg 11(1):34PubMedCrossRef Bökkerink GM, de Graaf EJ, Punt CJ, Nagtegaal ID, Rütten H, Nuyttens JJ, van Meerten E, Doornebosch PG, Tanis PJ, Derksen EJ, Dwarkasing RS, Marijnen CA, Cats A, Tollenaar RA, de Hingh IH, Rutten HJ, van der Schelling GP, Ten Tije AJ, Leijtens JW, Lammering G, Beets GL, Aufenacker TJ, Pronk A, Manusama ER, Hoff C, Bremers AJ, Verhoef C, de Wilt JH (2011) The CARTS study: Chemoradiation therapy for rectal cancer in the distal rectum followed by organ-sparing transanal endoscopic microsurgery. BMC Surg 11(1):34PubMedCrossRef
30.
go back to reference Petersen S, Hellmich G, von Mildenstein K, Porse G, Ludwig K (2006) Is surgery-only the adequate treatment approach for T2N0 rectal cancer? J Surg Oncol 93(5):350–354PubMedCrossRef Petersen S, Hellmich G, von Mildenstein K, Porse G, Ludwig K (2006) Is surgery-only the adequate treatment approach for T2N0 rectal cancer? J Surg Oncol 93(5):350–354PubMedCrossRef
31.
go back to reference Gérard JP, Azria D, Gourgou-Bourgade S, Martel-Laffay I, Hennequin C, Etienne PL, Vendrely V, François E, de La Roche G, Bouché O, Mirabel X, Denis B, Mineur L, Berdah JF, Mahé MA, Bécouarn Y, Dupuis O, Lledo G, Montoto-Grillot C, Conroy T (2010) Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: results of the phase III trial ACCORD 12/0405–Prodige 2. Clin Oncol 28(10):1638–1644 [Epub 2010 Mar 1]CrossRef Gérard JP, Azria D, Gourgou-Bourgade S, Martel-Laffay I, Hennequin C, Etienne PL, Vendrely V, François E, de La Roche G, Bouché O, Mirabel X, Denis B, Mineur L, Berdah JF, Mahé MA, Bécouarn Y, Dupuis O, Lledo G, Montoto-Grillot C, Conroy T (2010) Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: results of the phase III trial ACCORD 12/0405–Prodige 2. Clin Oncol 28(10):1638–1644 [Epub 2010 Mar 1]CrossRef
32.
go back to reference Aschele C, Cionini L, Lonardi S, Pinto C, Cordio S, Rosati G, Artale S, Tagliagambe A, Ambrosini G, Rosetti P, Bonetti A, Negru ME, Tronconi MC, Luppi G, Silvano G, Corsi DC, Bochicchio AM, Chiaulon G, Gallo M, Boni L (2011) Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01 randomized phase III trial. J Clin Oncol 29(20):2773–2780 [Epub 2011 May 23]PubMedCrossRef Aschele C, Cionini L, Lonardi S, Pinto C, Cordio S, Rosati G, Artale S, Tagliagambe A, Ambrosini G, Rosetti P, Bonetti A, Negru ME, Tronconi MC, Luppi G, Silvano G, Corsi DC, Bochicchio AM, Chiaulon G, Gallo M, Boni L (2011) Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01 randomized phase III trial. J Clin Oncol 29(20):2773–2780 [Epub 2011 May 23]PubMedCrossRef
33.
go back to reference Valentini V, Beets-Tan R, Borras JM et al (2008) Evidence and research in rectal cancer. Radiother Oncol 87:449–474PubMedCrossRef Valentini V, Beets-Tan R, Borras JM et al (2008) Evidence and research in rectal cancer. Radiother Oncol 87:449–474PubMedCrossRef
34.
go back to reference Glynne-Jones R, Anyamene N, Moran B, Harrison M (2012) Neoadjuvant chemotherapy in MRI-staged high-risk rectal cancer in addition to or as an alternative to preoperative chemoradiation? Ann Oncol [Epub ahead of print] Glynne-Jones R, Anyamene N, Moran B, Harrison M (2012) Neoadjuvant chemotherapy in MRI-staged high-risk rectal cancer in addition to or as an alternative to preoperative chemoradiation? Ann Oncol [Epub ahead of print]
35.
go back to reference Gérard A, Buyse M, Nordlinger B, Loygue J, Pène F, Kempf P, Bosset JF, Gignoux M, Arnaud JP, Desaive C et al (1988) Preoperative radiotherapy as adjuvant treatment in rectal cancer. Final results of a randomized study of the European Organization for Research and Treatment of Cancer (EORTC). Ann Surg 208(5):606–614PubMedCrossRef Gérard A, Buyse M, Nordlinger B, Loygue J, Pène F, Kempf P, Bosset JF, Gignoux M, Arnaud JP, Desaive C et al (1988) Preoperative radiotherapy as adjuvant treatment in rectal cancer. Final results of a randomized study of the European Organization for Research and Treatment of Cancer (EORTC). Ann Surg 208(5):606–614PubMedCrossRef
36.
go back to reference Pettersson D, Holm T, Iversen H, Blomqvist L, Glimelius B, Martling A (2012) Preoperative short-course radiotherapy with delayed surgery in primary rectal cancer. Br J Surg 99(4):577–583. doi:10.1002/bjs.7796 [Epub 2012 Jan 12]PubMedCrossRef Pettersson D, Holm T, Iversen H, Blomqvist L, Glimelius B, Martling A (2012) Preoperative short-course radiotherapy with delayed surgery in primary rectal cancer. Br J Surg 99(4):577–583. doi:10.​1002/​bjs.​7796 [Epub 2012 Jan 12]PubMedCrossRef
37.
go back to reference Pettersson D, Cedermark B, Holm T, Radu C, Påhlman L, Glimelius B, Martling A (2010) Interim analysis of the Stockholm III trial of preoperative radiotherapy regimens for rectal cancer. Br J Surg 97(4):580–587PubMedCrossRef Pettersson D, Cedermark B, Holm T, Radu C, Påhlman L, Glimelius B, Martling A (2010) Interim analysis of the Stockholm III trial of preoperative radiotherapy regimens for rectal cancer. Br J Surg 97(4):580–587PubMedCrossRef
38.
go back to reference Li JL, Ji JF, Cai Y, Li XF, Li YH, Wu H, Xu B, Dou FY, Li ZY, Bu ZD, Wu AW, Tham IW (2012) Preoperative concomitant boost intensity-modulated radiotherapy with oral capecitabine in locally advanced mid-low rectal cancer: a phase II trial. Radiother Oncol 102(1):4–9 [Epub 2011 Sep 6]PubMedCrossRef Li JL, Ji JF, Cai Y, Li XF, Li YH, Wu H, Xu B, Dou FY, Li ZY, Bu ZD, Wu AW, Tham IW (2012) Preoperative concomitant boost intensity-modulated radiotherapy with oral capecitabine in locally advanced mid-low rectal cancer: a phase II trial. Radiother Oncol 102(1):4–9 [Epub 2011 Sep 6]PubMedCrossRef
39.
go back to reference Gasent Blesa JM, Garde Noguera J, Laforga Canales JB, Giner Bosch V, Alberola A, Soler Tortosa M, Peris Godoy M, Sanchez JL, Provencio Pulla M, Alberola Candel V (2012) Phase II trial of concomitant neoadjuvant chemotherapy with oxaliplatin and capecitabine and intensity-modulated radiotherapy (IMRT) in rectal cancer. J Gastrointest Cancer, Feb 28 Gasent Blesa JM, Garde Noguera J, Laforga Canales JB, Giner Bosch V, Alberola A, Soler Tortosa M, Peris Godoy M, Sanchez JL, Provencio Pulla M, Alberola Candel V (2012) Phase II trial of concomitant neoadjuvant chemotherapy with oxaliplatin and capecitabine and intensity-modulated radiotherapy (IMRT) in rectal cancer. J Gastrointest Cancer, Feb 28
40.
go back to reference Kalady MF, de Campos-Lobato LF, Stocchi L, Geisler DP, Dietz D, Lavery IC, Fazio VW (2009) Predictive factors of pathologic complete response after neoadjuvant chemoradiation for rectal cancer. Ann Surg 250(4):582–589 Kalady MF, de Campos-Lobato LF, Stocchi L, Geisler DP, Dietz D, Lavery IC, Fazio VW (2009) Predictive factors of pathologic complete response after neoadjuvant chemoradiation for rectal cancer. Ann Surg 250(4):582–589
41.
go back to reference Evans J, Tait D, Swift I, Pennert K, Tekkis P, Wotherspoon A, Chau I, Cunningham D, Brown G (2011) Timing of surgery following preoperative therapy in rectal cancer: the need for a prospective randomized trial? Colon Rectum 54(10):1251–1259CrossRef Evans J, Tait D, Swift I, Pennert K, Tekkis P, Wotherspoon A, Chau I, Cunningham D, Brown G (2011) Timing of surgery following preoperative therapy in rectal cancer: the need for a prospective randomized trial? Colon Rectum 54(10):1251–1259CrossRef
42.
go back to reference Garcia-Aguilar J, Smith DD, Avila K, Bergsland EK, Chu P (2011) Timing of Rectal Cancer Response to Chemoradiation Consortium. Optimal timing of surgery after chemoradiation for advanced rectal cancer: preliminary results of a multicenter, nonrandomized phase II prospective trial. Ann Surg 254(1):97–102PubMedCrossRef Garcia-Aguilar J, Smith DD, Avila K, Bergsland EK, Chu P (2011) Timing of Rectal Cancer Response to Chemoradiation Consortium. Optimal timing of surgery after chemoradiation for advanced rectal cancer: preliminary results of a multicenter, nonrandomized phase II prospective trial. Ann Surg 254(1):97–102PubMedCrossRef
43.
go back to reference Dhadda AS, Zaitoun AM, Bessell EM (2009) Regression of rectal cancer with radiotherapy with or without concurrent capecitabine–optimising the timing of surgical resection. Clin Oncol (R Coll Radiol) 21(1):23–31 [Epub 2008 Nov 21]CrossRef Dhadda AS, Zaitoun AM, Bessell EM (2009) Regression of rectal cancer with radiotherapy with or without concurrent capecitabine–optimising the timing of surgical resection. Clin Oncol (R Coll Radiol) 21(1):23–31 [Epub 2008 Nov 21]CrossRef
44.
go back to reference de Campos-Lobato LF, Geisler DP, da Luz Moreira A, Stocchi L, Dietz D, Kalady MF (2011) Neoadjuvant therapy for rectal cancer: the impact of longer interval between chemoradiation and surgery. J Gastrointest Surg 15(3):444–450 [Epub 2010 Dec 8]PubMedCrossRef de Campos-Lobato LF, Geisler DP, da Luz Moreira A, Stocchi L, Dietz D, Kalady MF (2011) Neoadjuvant therapy for rectal cancer: the impact of longer interval between chemoradiation and surgery. J Gastrointest Surg 15(3):444–450 [Epub 2010 Dec 8]PubMedCrossRef
45.
go back to reference Garcia-Aguilar J, Shi Q, Thomas CR Jr, Chan E, Cataldo P, Marcet J, Medich D, Pigazzi A, Oommen S, Posner MC (2012) A phase II trial of neoadjuvant chemoradiation and local excision for T2N0 rectal cancer: preliminary results of the ACOSOG Z6041 trial. Ann Surg Oncol 19(2):384–391 [Epub 2011 Jul 14]PubMedCrossRef Garcia-Aguilar J, Shi Q, Thomas CR Jr, Chan E, Cataldo P, Marcet J, Medich D, Pigazzi A, Oommen S, Posner MC (2012) A phase II trial of neoadjuvant chemoradiation and local excision for T2N0 rectal cancer: preliminary results of the ACOSOG Z6041 trial. Ann Surg Oncol 19(2):384–391 [Epub 2011 Jul 14]PubMedCrossRef
46.
go back to reference Martin ST, Heneghan HM, Winter DC (2012) Systematic review and meta-analysis of outcomes following pathological complete response to neoadjuvant chemoradiotherapy for rectal cancer. Br J Surg. doi:10.1002/bjs.8702 Martin ST, Heneghan HM, Winter DC (2012) Systematic review and meta-analysis of outcomes following pathological complete response to neoadjuvant chemoradiotherapy for rectal cancer. Br J Surg. doi:10.​1002/​bjs.​8702
47.
go back to reference Maas M, Nelemans PJ, Valentini V, Das P et al (2010) Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data. Lancet Oncol 11:835–844PubMedCrossRef Maas M, Nelemans PJ, Valentini V, Das P et al (2010) Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data. Lancet Oncol 11:835–844PubMedCrossRef
48.
go back to reference Martin ST, Heneghan HM, Winter DC (2012) Systematic review of outcomes after intersphincteric resection for low rectal cancer. Br J Surg. doi:10.1002/bjs.8677 Martin ST, Heneghan HM, Winter DC (2012) Systematic review of outcomes after intersphincteric resection for low rectal cancer. Br J Surg. doi:10.​1002/​bjs.​8677
49.
go back to reference Lezoche G, Baldarelli M, Guerrieri M, Paganini AM, De Sanctis A, Bartolacci S, Lezoche E (2008) A prospective randomized study with a 5-year minimum follow-up evaluation of transanal endoscopic microsurgery versus laparoscopic total mesorectal excision after neoadjuvant therapy. Surg Endosc 22(2):352–358PubMedCrossRef Lezoche G, Baldarelli M, Guerrieri M, Paganini AM, De Sanctis A, Bartolacci S, Lezoche E (2008) A prospective randomized study with a 5-year minimum follow-up evaluation of transanal endoscopic microsurgery versus laparoscopic total mesorectal excision after neoadjuvant therapy. Surg Endosc 22(2):352–358PubMedCrossRef
50.
go back to reference Lim L, Chao M, Shapiro J, Millar JL, Kipp D, Rezo A, Fong A, Jones IT, McLaughlin S, Gibbs P (2007) Long-term outcomes of patients with localized rectal cancer treated with chemoradiation or radiotherapy alone because of medical inoperability or patient refusal. Dis Colon Rectum 50(12):2032–2039 [Epub 2007 Sep 26]PubMedCrossRef Lim L, Chao M, Shapiro J, Millar JL, Kipp D, Rezo A, Fong A, Jones IT, McLaughlin S, Gibbs P (2007) Long-term outcomes of patients with localized rectal cancer treated with chemoradiation or radiotherapy alone because of medical inoperability or patient refusal. Dis Colon Rectum 50(12):2032–2039 [Epub 2007 Sep 26]PubMedCrossRef
51.
go back to reference Maas M, Beets-Tan RG, Lambregts DM, Lammering G, Nelemans PJ, Engelen SM, van Dam RM, Jansen RL, Sosef M, Leijtens JW, Hulsewé KW, Buijsen J, Beets GL (2011) Wait-and-see policy for clinical complete responders after chemoradiation for rectal cancer. J Clin Oncol 29(35):4633–4640 [Epub 2011 Nov 7]PubMedCrossRef Maas M, Beets-Tan RG, Lambregts DM, Lammering G, Nelemans PJ, Engelen SM, van Dam RM, Jansen RL, Sosef M, Leijtens JW, Hulsewé KW, Buijsen J, Beets GL (2011) Wait-and-see policy for clinical complete responders after chemoradiation for rectal cancer. J Clin Oncol 29(35):4633–4640 [Epub 2011 Nov 7]PubMedCrossRef
52.
go back to reference Dalton R, Velineni R, Osborne M, Thomas R, Harries S, Gee A, Daniels I (2012) A single centre experience of chemo-radiotherapy for rectal cancer: Is there potential for non-operative management? Colorectal Dis 14(5):567–571 Dalton R, Velineni R, Osborne M, Thomas R, Harries S, Gee A, Daniels I (2012) A single centre experience of chemo-radiotherapy for rectal cancer: Is there potential for non-operative management? Colorectal Dis 14(5):567–571
53.
go back to reference Pietsch AP, Fietkau R, Klautke G, Foitzik T, Klar E (2007) Effect of neoadjuvant chemoradiation on postoperative fecal continence and anal sphincter function in rectal cancer patients. Int J Colorectal Dis 22(11):1311–1317 [Epub 2007 May 12]PubMedCrossRef Pietsch AP, Fietkau R, Klautke G, Foitzik T, Klar E (2007) Effect of neoadjuvant chemoradiation on postoperative fecal continence and anal sphincter function in rectal cancer patients. Int J Colorectal Dis 22(11):1311–1317 [Epub 2007 May 12]PubMedCrossRef
54.
go back to reference Giordano P, Efron J, Vernava AM 3rd, Weiss EG, Nogueras JJ, Wexner SD (2006) Strategies of follow-up for colorectal cancer: a survey of the American Society of Colon and Rectal Surgeons. Tech Coloproctol 10(3):199–207 [Epub 2006 Sep 20]PubMedCrossRef Giordano P, Efron J, Vernava AM 3rd, Weiss EG, Nogueras JJ, Wexner SD (2006) Strategies of follow-up for colorectal cancer: a survey of the American Society of Colon and Rectal Surgeons. Tech Coloproctol 10(3):199–207 [Epub 2006 Sep 20]PubMedCrossRef
55.
go back to reference Asteria CR, Gagliardi G, Pucciarelli S, Romano G, Infantino A, La Torre F, Tonelli F, Martin F, Pulica C, Ripetti V, Diana G, Amicucci G, Carlini M, Sommariva A, Vinciguerra G, Poddie DB, Amato A, Bassi R, Galleano R, Veronese E, Mancini S, Pescio G, Occelli GL, Bracchitta S, Castagnola M, Pontillo T, Cimmino G, Prati U, Vincenti R (2008) Anastomotic leaks after anterior resection for mid and low rectal cancer: survey of the Italian Society of Colorectal Surgery. Tech Coloproctol 12(2):103–110 [Epub 2008 Jun 10]PubMedCrossRef Asteria CR, Gagliardi G, Pucciarelli S, Romano G, Infantino A, La Torre F, Tonelli F, Martin F, Pulica C, Ripetti V, Diana G, Amicucci G, Carlini M, Sommariva A, Vinciguerra G, Poddie DB, Amato A, Bassi R, Galleano R, Veronese E, Mancini S, Pescio G, Occelli GL, Bracchitta S, Castagnola M, Pontillo T, Cimmino G, Prati U, Vincenti R (2008) Anastomotic leaks after anterior resection for mid and low rectal cancer: survey of the Italian Society of Colorectal Surgery. Tech Coloproctol 12(2):103–110 [Epub 2008 Jun 10]PubMedCrossRef
56.
go back to reference Ooi K, Frizelle F, Ong E, Faragher I (2012) Current practice in preoperative therapy and surgical management of locally advanced rectal cancer: A bi-national survey. Colorectal Dis 14(7):814–820 Ooi K, Frizelle F, Ong E, Faragher I (2012) Current practice in preoperative therapy and surgical management of locally advanced rectal cancer: A bi-national survey. Colorectal Dis 14(7):814–820
Metadata
Title
Management of distal rectal cancer: results from a national survey
Authors
G. Melotti
E. De Antoni
A. Habr-Gama
A. Minicozzi
Publication date
01-03-2013
Publisher
Springer Milan
Published in
Updates in Surgery / Issue 1/2013
Print ISSN: 2038-131X
Electronic ISSN: 2038-3312
DOI
https://doi.org/10.1007/s13304-012-0192-x

Other articles of this Issue 1/2013

Updates in Surgery 1/2013 Go to the issue