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01-02-2016 | Original Article

Association of the functional BCL-2 rs2279115 genetic variant and small cell lung cancer

Authors: Xinyu Yang, Feng Gao, Fei Ma, Yanli Ren, Hongwei Chen, Xue Liang, Sichong Han, Xiangyu Xiong, Wenting Pan, Changchun Zhou, Liqing Zhou, Ming Yang

Published in: Tumor Biology | Issue 2/2016

Abstract

As a well-known oncogene, B cell lymphoma-2 (BCL-2) can promote cancer cell survival through preventing their apoptosis. Several functional BCL-2 single nucleotide polymorphisms (SNPs), such as rs2279115, rs1801018, and rs1564483, have been identified and might contribute to cancer susceptibility. However, the involvement of these SNPs in small cell lung cancer (SCLC) was still unclear. As a result, we investigated associations between these three genetic variants and SCLC risk in a case-control design. Genotypes were determined in two independent case-control sets consisted of 520 SCLC patients and 1040 controls from two medical centers. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated utilizing unconditional logistic regression. We found that only BCL-2 rs2279115 genetic variant significantly contributed to decreased SCLC risk in Chinese Han populations, with the rs2279115 A allele as the protective allele. Stratified analyses of association between BCL2 rs2279115 SNP and SCLC risk indicated that the functional polymorphism was only significantly associated with decreased risk of the limited stage SCLC but not the extensive stage disease. Our results indicate that the BCL-2 rs2279115 genetic variant was associated with SCLC risk in Chinese populations and support the hypothesis that SNPs in regulatory regions of oncogenes might contribute to cancer susceptibility.

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Title: Association of the functional BCL-2 rs2279115 genetic variant and small cell lung cancer
Authors: Xinyu Yang
Feng Gao
Fei Ma
Yanli Ren
Hongwei Chen
Xue Liang
Sichong Han
Xiangyu Xiong
Wenting Pan
Changchun Zhou
Liqing Zhou
Ming Yang
Publication date: 01-02-2016
Publisher: Springer Netherlands
Published in: Tumor Biology / Issue 2/2016
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-015-3934-9

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