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01-10-2014 | Review

Long noncoding RNA HOTAIR involvement in cancer

Authors: Yansheng Wu, Li Zhang, Yang Wang, Hui Li, Xiubao Ren, Feng Wei, Wenwen Yu, Xudong Wang, Lun Zhang, Jinpu Yu, Xishan Hao

Published in: Tumor Biology | Issue 10/2014

Abstract

Evidences have been provided that long noncoding RNAs (lncRNAs) act as key molecules in epigenetic regulation and are involved in the development process of cancer in recent studies. HOX transcript antisense RNA (HOTAIR), a long intergenic noncoding RNA (lincRNA), functions as a molecular scaffold to link and target two histone modification complexes PRC2 and LSD1, then reprograms chromatin states by couples histone H3K27 methylation and H3K4 demethylation for epigenetic gene silencing to promote cancer metastasis. HOTAIR, regarded as an oncogene, is pervasively overexpressed in most solid cancers and correlated with tumor invasion, progression, metastasis, and poor prognosis, and HOTAIR has been proven to play a critical role in most biological process of cancer and would be a potential new target in cancer therapy.

Ponting CP et al. Evolution and functions of long noncoding RNAs. Cell. 2009;136(4):629–41.CrossRefPubMed

Jeggari A et al. miRcode: a map of putative microRNA target sites in the long non-coding transcriptome. Bioinformatics. 2012;28(15):2062–3.PubMedCentralCrossRefPubMed

Jalali S et al. Systematic transcriptome wide analysis of lncRNA-miRNA interactions. PLoS One. 2013;8(2):e53823.PubMedCentralCrossRefPubMed

Lee JT. Epigenetic regulation by long noncoding RNAs. Science. 2012;338(6113):1435–9.CrossRefPubMed

Maruyama R, Suzuki H. Long noncoding RNA involvement in cancer. BMB Rep. 2012;45(11):604–11.PubMedCentralCrossRefPubMed

Kung JT et al. Long noncoding RNAs: past, present, and future. Genetics. 2013;193(3):651–69.PubMedCentralCrossRefPubMed

Mercer TR, Mattick JS. Structure and function of long noncoding RNAs in epigenetic regulation. Nat Struct Mol Biol. 2013;20(3):300–7.CrossRefPubMed

Gutschner T, Diederichs S. The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol. 2012;9(6):703–19.PubMedCentralCrossRefPubMed

Chu C et al. Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions. Mol Cell. 2011;44(4):667–78.PubMedCentralCrossRefPubMed

10.

Tsai MC et al. Long noncoding RNA as modular scaffold of histone modification complexes. Science. 2010;329(5992):689–93.PubMedCentralCrossRefPubMed

11.

Gupta RA et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 2010;464(7291):1071–6.PubMedCentralCrossRefPubMed

12.

Rinn JL et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell. 2007;129(7):1311–23.PubMedCentralCrossRefPubMed

13.

Schorderet P, Duboule D. Structural and functional differences in the long non-coding RNA HOTAIR in mouse and human. PLoS Genet. 2011;7(5):e1002071.PubMedCentralCrossRefPubMed

14.

He S et al. The sequence, structure and evolutionary features of HOTAIR in mammals. BMC Evol Biol. 2011;11:102.PubMedCentralCrossRefPubMed

15.

Ulitsky I, Bartel DP. lincRNAs: genomics, evolution, and mechanisms. Cell. 2013;154(1):26–46.PubMedCentralCrossRefPubMed

16.

Guttman M, Rinn JL. Modular regulatory principles of large non-coding RNAs. Nature. 2012;482(7385):339–46.PubMedCentralCrossRefPubMed

17.

Wang L et al. BRCA1 is a negative modulator of the PRC2 complex. EMBO J. 2013;32(11):1584–97.PubMedCentralCrossRefPubMed

18.

Kogo R et al. Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res. 2011;71(20):6320–6.CrossRefPubMed

19.

Kim K et al. HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene. 2013;32(13):1616–25.PubMedCentralCrossRefPubMed

20.

Chisholm KM et al. Detection of long non-coding RNA in archival tissue: correlation with polycomb protein expression in primary and metastatic breast carcinoma. PLoS One. 2012;7(10):e47998.PubMedCentralCrossRefPubMed

21.

Bhan A et al. Antisense transcript long noncoding RNA (lncRNA) HOTAIR is transcriptionally induced by estradiol. J Mol Biol. 2013;425(19):3707–22.PubMedCentralCrossRefPubMed

22.

Kuzmichev A et al. Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. Proc Natl Acad Sci U S A. 2005;102(6):1859–64.PubMedCentralCrossRefPubMed

23.

Sparmann A, van Lohuizen M. Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer. 2006;6(11):846–56.CrossRefPubMed

24.

Simon JA, Lange CA. Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat Res. 2008;647(1–2):21–9.CrossRefPubMed

25.

Kirmizis A et al. Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Genes Dev. 2004;18(13):1592–605.PubMedCentralCrossRefPubMed

26.

Zhuang Y et al. Induction of long intergenic non-coding RNA HOTAIR in lung cancer cells by type I collagen. J Hematol Oncol. 2013;6:35.PubMedCentralCrossRefPubMed

27.

Nakagawa T et al. Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer. Biochem Biophys Res Commun. 2013;436(2):319–24.CrossRefPubMed

28.

Ishibashi M et al. Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma. Oncol Rep. 2013;29(3):946–50.PubMed

29.

Geng YJ et al. Large intervening non-coding RNA HOTAIR is associated with hepatocellular carcinoma progression. J Int Med Res. 2011;39(6):2119–28.CrossRefPubMed

30.

Yang Z et al. Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann Surg Oncol. 2011;18(5):1243–50.CrossRefPubMed

31.

De Craene B, Berx G. Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer. 2013;13(2):97–110.CrossRefPubMed

32.

Xu ZY et al. Knockdown of long non-coding RNA HOTAIR suppresses tumor invasion and reverses epithelial-mesenchymal transition in gastric cancer. Int J Biol Sci. 2013;9(6):587–97.PubMedCentralCrossRefPubMed

33.

Hajjari M et al. Up-regulation of HOTAIR long non-coding RNA in human gastric adenocarcinoma tissues. Med Oncol. 2013;30(3):670.CrossRefPubMed

34.

Endo H et al. Enhanced expression of long non-coding RNA HOTAIR is associated with the development of gastric cancer. PLoS One. 2013;8(10):e77070.PubMedCentralCrossRefPubMed

35.

Niinuma T et al. Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors. Cancer Res. 2012;72(5):1126–36.CrossRefPubMed

36.

El-Naggar AK et al. Frequent loss of imprinting at the IGF2 and H19 genes in head and neck squamous carcinoma. Oncogene. 1999;18(50):7063–9.CrossRefPubMed

37.

Feng J et al. Expression of long non-coding ribonucleic acid metastasis-associated lung adenocarcinoma transcript-1 is correlated with progress and apoptosis of laryngeal squamous cell carcinoma. Head Neck Oncol. 2012;4(2):46.

38.

Nie Y et al. Long non-coding RNA HOTAIR is an independent prognostic marker for nasopharyngeal carcinoma progression and survival. Cancer Sci. 2013;104(4):458–64.CrossRefPubMed

39.

Tang L et al. Long noncoding RNA HOTAIR is associated with motility, invasion, and metastatic potential of metastatic melanoma. Biomed Res Int. 2013;2013:251098.PubMedCentralPubMed

40.

Chiyomaru T et al. Genistein inhibits prostate cancer cell growth by targeting miR-34a and oncogenic HOTAIR. PLoS One. 2013;8(8):e70372.PubMedCentralCrossRefPubMed

41.

Milhem MM et al. Correlation of MTDH/AEG-1 and HOTAIR expression with metastasis and response to treatment in sarcoma patients. J Cancer Sci Ther. 2011;S5:4.

42.

Lv XB et al. Long noncoding RNA HOTAIR is a prognostic marker for esophageal squamous cell carcinoma progression and survival. PLoS One. 2013;8(5):e63516.PubMedCentralCrossRefPubMed

43.

Liu XH et al. The long non-coding RNA HOTAIR indicates a poor prognosis and promotes metastasis in non-small cell lung cancer. BMC Cancer. 2013;13(1):464.PubMedCentralCrossRefPubMed

44.

Huang L, et al. Overexpression of long noncoding RNA HOTAIR predicts a poor prognosis in patients with cervical cancer. Arch Gynecol Obstet. 2014.

45.

Qiu JJ et al. Overexpression of long non-coding RNA HOTAIR predicts poor patient prognosis and promotes tumor metastasis in epithelial ovarian cancer. Gynecol Oncol. 2014;134(1):121–8.CrossRefPubMed

46.

Li D et al. Long intergenic noncoding RNA HOTAIR is overexpressed and regulates PTEN methylation in laryngeal squamous cell carcinoma. Am J Pathol. 2013;182(1):64–70.CrossRefPubMed

47.

Franco-Chuaire ML et al. Epithelial-mesenchymal transition (EMT): principles and clinical impact in cancer therapy. Invest Clin. 2013;54(2):186–205.PubMed

48.

Gao D et al. Microenvironmental regulation of epithelial-mesenchymal transitions in cancer. Cancer Res. 2012;72(19):4883–9.PubMedCentralCrossRefPubMed

49.

Alves CP, et al. The lincRNA HOTAIR is required for epithelial-to-mesenchymal transition and stemness maintenance of cancer cells lines. Stem Cells. 2013.

50.

Ma L et al. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature. 2007;449(7163):682–8.CrossRefPubMed

51.

Wan Y, Chang HY. HOTAIR: flight of noncoding RNAs in cancer metastasis. Cell Cycle. 2010;9(17):3391–2.PubMedCentralCrossRefPubMed

52.

Haenisch S, Cascorbi I. miRNAs as mediators of drug resistance. Epigenomics. 2012;4(4):369–81.CrossRefPubMed

53.

Chen J et al. Enhancer of zeste homolog 2 is overexpressed and contributes to epigenetic inactivation of p21 and phosphatase and tensin homolog in B-cell acute lymphoblastic leukemia. Exp Biol Med (Maywood). 2012;237(9):1110–6.CrossRef

54.

Cao W et al. EZH2 promotes malignant behaviors via cell cycle dysregulation and its mRNA level associates with prognosis of patient with non-small cell lung cancer. PLoS One. 2012;7(12):e52984.PubMedCentralCrossRefPubMed

Title: Long noncoding RNA HOTAIR involvement in cancer
Authors: Yansheng Wu
Li Zhang
Yang Wang
Hui Li
Xiubao Ren
Feng Wei
Wenwen Yu
Xudong Wang
Lun Zhang
Jinpu Yu
Xishan Hao
Publication date: 01-10-2014
Publisher: Springer Netherlands
Published in: Tumor Biology / Issue 10/2014
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-014-2523-7

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