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01-11-2014 | Research Article

Association between the XRCC1 Arg194Trp polymorphism and risk of cancer: evidence from 201 case–control studies

Authors: Yan-Zhong Feng, Yi-Ling Liu, Xiao-Feng He, Wu Wei, Xu-Liang Shen, Dao-Lin Xie

Published in: Tumor Biology | Issue 11/2014

Abstract

The Arg194Trp polymorphism in the X-ray cross-complementing group 1 (XRCC1) had been implicated in cancer susceptibility. The previous published data on the association between XRCC1 Arg194Trp polymorphism and cancer risk remained controversial. Hence, we performed a meta-analysis to investigate the association between cancer susceptibility and XRCC1 Arg194Trp (59,227 cases and 81,587 controls from 201 studies) polymorphism in different inheritance models. We used odds ratios with 95 % confidence intervals to assess the strength of the association. Overall, significantly increased cancer risk was found (recessive model: (odds ration [OR] = 1.18, 95 % confidence interval [CI] = 1.09–1.27; homozygous model: OR = 1.21, 95 % CI = 1.10–1.33; additive model: OR = 1.05, 95 % CI = 1.01–1.09) when all eligible studies were pooled into the meta-analysis. In further stratified and sensitivity analyses, significantly increased glioma risk was found among Asians, significantly decreased lung cancer risk was found among Caucasians, and significant increased breast cancer risk was found among hospital-based studies. In summary, this meta-analysis suggests that Arg194Trp polymorphism may be associated with increased breast cancer risk, Arg194Trp polymorphism is associated with increased glioma risk among Asians, and Arg194Trp polymorphism is associated with decreased lung cancer risk among Caucasians. In addition, our work also points out the importance of new studies for Arg194Trp association in some cancer types, such as gastric, pancreatic, prostate, and nasopharyngeal cancers, where at least some of the covariates responsible for heterogeneity could be controlled, to obtain a more conclusive understanding about the function of the XRCC1 Arg194Trp polymorphism in cancer development (I ² > 75 %).

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Title: Association between the XRCC1 Arg194Trp polymorphism and risk of cancer: evidence from 201 case–control studies
Authors: Yan-Zhong Feng
Yi-Ling Liu
Xiao-Feng He
Wu Wei
Xu-Liang Shen
Dao-Lin Xie
Publication date: 01-11-2014
Publisher: Springer Netherlands
Published in: Tumor Biology / Issue 11/2014
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-014-2326-x

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