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Tumor Biology
Published in: Tumor Biology 6/2014

01-06-2014 | Research Article

APE1 Asp148Glu polymorphism and lung cancer susceptibility

Authors: Liyun Cai, Yingjv Fu, Yuanyue Zhang

Published in: Tumor Biology | Issue 6/2014

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Abstract

Apurinic/apyrimidinic endonuclease 1 (APE1) is a key enzyme in base excision repair (BER) pathway for the removal of many oxidized and alkylated bases. Single-nucleotide polymorphisms of the APE1gene have been demonstrated to be involved in carcinogenesis. However, the association between APE1 Asp148Glu polymorphism and lung cancer risk remains inconclusive. To derive a precise estimate for this association, we carried out an updated meta-analysis by pooling data thus far published. The pooled odds ratio (OR) with 95 % confidence interval (95 % CI) was calculated to assess the role of APE1 Asp148Glu polymorphism in lung carcinogenesis. The pooled ORs suggested that variant genotypes of APE1 Asp148Glu were modestly associated with an elevated risk of lung cancer (GluGlu vs. AspAsp, OR = 1.22, 95 % CI 1.01–1.48, P = 0.038; GluGlu vs. AspAsp + AspGlu, OR = 1.19, 95 % CI 1.02–1.39, P = 0.023). The relationship was also observed in studies conducted among Asians, but not Caucasians. Sensitivity analysis further confirmed the findings. The meta-analysis shows that the polymorphism of APE1 Asp148Glu exerts risk effect on lung cancer development.
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Metadata
Title
APE1 Asp148Glu polymorphism and lung cancer susceptibility
Authors
Liyun Cai
Yingjv Fu
Yuanyue Zhang
Publication date
01-06-2014
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 6/2014
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-014-1681-y

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