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Tumor Biology
Published in: Tumor Biology 5/2014

01-05-2014 | Research Article

Sprouty4 interferes with cell proliferation and migration of breast cancer-derived cell lines

Authors: Vanita Vanas, Elsa Mühlbacher, Rosana Kral, Hedwig Sutterlüty-Fall

Published in: Tumor Biology | Issue 5/2014

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Abstract

Sprouty proteins are modulators of mitogen-induced signal transduction processes and therefore can influence the process of cancerogenesis. In particular, Sprouty2 has been shown to have an important role in cancer development of many tumor entities including breast cancer. In this report, we investigated the role of Sprouty4 in breast cancer-derived cell lines. We have found that ectopic Sprouty4 expression inhibits cell proliferation of breast cancer cell lines independently of their endogenous expression levels. Corroborating Sprouty4 downregulation causes accelerated growth. Furthermore, we demonstrate that an increase in Sprouty4 content interferes with serum-induced activation of mitogen-activated protein kinase pathway. Additionally, Sprouty4 expression negatively influences cell migration. These data suggest that Sprouty4 is a possible candidate for a tumor suppressor in breast cancer.
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Metadata
Title
Sprouty4 interferes with cell proliferation and migration of breast cancer-derived cell lines
Authors
Vanita Vanas
Elsa Mühlbacher
Rosana Kral
Hedwig Sutterlüty-Fall
Publication date
01-05-2014
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 5/2014
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-013-1587-0

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