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Tumor Biology
Published in: Tumor Biology 2/2014

01-02-2014 | RESEARCH ARTICLE

The Thr241Met polymorphism in the XRCC3 gene is associated with increased risk of cancer in Chinese mainland populations

Authors: Liang Du, Tianyuan Xiong, Qing He, Yayi Wang, Jiani Shen, Yuanling Peng, Qingyi Jia, Jiqiao Yang, Yonggang Zhang, Jin Huang

Published in: Tumor Biology | Issue 2/2014

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Abstract

The Thr241Met polymorphism in XRCC3 gene may affect the DNA repair pathways and be associated with the risk of cancer. However, the results of previous studies are inconsistent in Chinese mainland populations. The objective of this study is to investigate the association between the Thr241Met polymorphism in XRCC3 gene and risk of cancer for the Chinese Mainland populations by meta-analysis. We searched PubMed database, Embase database, CNKI database, and Wanfang database, and the last search was updated on July 24, 2013. Statistical analysis was performed using RevMan4.2 and Stata10.0 software. Finally, a total of 23 case–control studies in 23 articles were included. The results suggested a significant association between the Thr241Met polymorphism in XRCC3 gene and cancer risk in Chinese mainland populations (Met/Met + Thr/Met vs. Thr/Thr: OR = 1.25, 95 % CI = 1.02–1.54, P = 0.04). In the subgroup analyses by cancer types, significant associations were found in cervical cancer and nasopharyngeal cancer. The current meta-analysis suggested that the Thr241Met polymorphism in the XRCC3 gene may be a risk factor for cancer in Chinese mainland populations. In the future, more case–control studies are needed to validate these results.
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Metadata
Title
The Thr241Met polymorphism in the XRCC3 gene is associated with increased risk of cancer in Chinese mainland populations
Authors
Liang Du
Tianyuan Xiong
Qing He
Yayi Wang
Jiani Shen
Yuanling Peng
Qingyi Jia
Jiqiao Yang
Yonggang Zhang
Jin Huang
Publication date
01-02-2014
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 2/2014
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-013-1187-z

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