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Published in: Tumor Biology 4/2013

01-08-2013 | Review

MicroRNAs in osteosarcoma: diagnostic and therapeutic aspects

Authors: Jinglei Miao, Song Wu, Zhi Peng, Mousumi Tania, Chaoyue Zhang

Published in: Tumor Biology | Issue 4/2013

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Abstract

MicroRNAs (miRNAs) are small RNA molecules, which can interfere with the expression of several genes and act as gene regulator. miRNAs have been proved as a successful diagnostic and therapeutic tool in several cancers. In this review, the differential expression of miRNAs in osteosarcoma and their possibility to be used as diagnostic and therapeutic tools have been discussed. Osteosarcoma is the most common primary bone tumor that mainly affects children and adolescents. The current treatment of osteosarcoma remains difficult, and osteosarcoma causes many deaths because of its complex pathogenesis and resistance to conventional treatments. Several studies demonstrated that the differential expression patterns of miRNAs are a promising tool for the diagnosis and treatment of osteosarcoma. Although some aspect of the mechanism of action of miRNAs in controlling osteosarcoma has been identified (e.g., targeting the Notch signaling pathway), it is far beyond to the clear understanding of miRNA targets in osteosarcoma. Identification of the specific target of miRNAs may aid molecular targets for drug development and future relief of osteosarcoma.
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Metadata
Title
MicroRNAs in osteosarcoma: diagnostic and therapeutic aspects
Authors
Jinglei Miao
Song Wu
Zhi Peng
Mousumi Tania
Chaoyue Zhang
Publication date
01-08-2013
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 4/2013
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-013-0940-7

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