Skip to main content
Top
Published in: Insights into Imaging 6/2015

Open Access 01-12-2015 | Pictorial Review

Hepatic tuberculosis: a multimodality imaging review

Authors: Chandan Kakkar, Ashwin M. Polnaya, Prakashini Koteshwara, S. Smiti, K. V. Rajagopal, Ankur Arora

Published in: Insights into Imaging | Issue 6/2015

Login to get access

Abstract

Objectives

We aim to illustrate the multimodal imaging spectrum of hepatic involvement in tuberculosis (TB). Whilst disseminated tuberculosis on imaging typically manifests as multiple small nodular lesions scattered in the liver parenchyma, isolated hepatic tuberculosis remains a rare and intriguing entity.

Methods

Indubitably, imaging is the mainstay for detection of tubercular hepatic lesions which display a broad spectrum of imaging manifestations on different modalities. While sonography and computed tomography (CT) findings have been described in some detail, there is a paucity of literature on magnetic resonance imaging (MRI) features. Due to a significant overlap with other commoner and similar appearing hepatic lesions, hepatic tuberculosis is often either misdiagnosed or labelled as indeterminate lesions. This article is a compendium of cases highlighting the spectrum of imaging patterns that can be encountered in patients with isolated primary hepatic tuberculosis as well as disseminated (secondary) disease. Rare patterns of primary disease such as tubercular cholangitis, hypervascular liver masses, and those with vascular complications are also illustrated and discussed.

Conclusions

Imaging plays a valuable role in the detection of tubercular hepatic lesions. Also, imaging can be helpful in their characterisation and for assessing associated complications.

Teaching points

Hepatic TB has myriad imaging manifestations and is often confounded with neoplastic lesions.
Imaging patterns include miliary TB, macronodular TB, serohepatic TB and tubercular cholangitis.
Concurrent splenic, nodal or pulmonary involvements are helpful pointers towards the diagnosis.
Miliary calcifications along the bile ducts are characteristic of tubercular cholangitis.
Histological/microbiological confirmation is often necessary to confirm the diagnosis.
Literature
2.
go back to reference Kakkar, Koteshwara P, Polnaya AM, Rajagopal K et al (2011) Imaging patterns of hepuberculosis on MDCT: Can we predict the diagnosis? Available on the Electronic Poster Online System (EPOS) of the European Society of Radiology. doi: 10.1594/ecr2011/C-0873 Kakkar, Koteshwara P, Polnaya AM, Rajagopal K et al (2011) Imaging patterns of hepuberculosis on MDCT: Can we predict the diagnosis? Available on the Electronic Poster Online System (EPOS) of the European Society of Radiology. doi: 10.​1594/​ecr2011/​C-0873
3.
4.
go back to reference World Health Organization (2011) WHO Report: Global tuberculosis control? WHO, Geneva World Health Organization (2011) WHO Report: Global tuberculosis control? WHO, Geneva
5.
go back to reference Raviglione MC, Snider DE, Kochi A (1995) Global epidemiology of tuberculosis: morbidity and mortality of a worldwide epidemic. JAMA 273:220–226CrossRefPubMed Raviglione MC, Snider DE, Kochi A (1995) Global epidemiology of tuberculosis: morbidity and mortality of a worldwide epidemic. JAMA 273:220–226CrossRefPubMed
6.
go back to reference Tan TC, Cheung AY, Wan WY et al (1997) Tuberculoma of the liver presenting as a hyperechoic mass on ultrasound. Br J Radiol 70:1293–1295CrossRefPubMed Tan TC, Cheung AY, Wan WY et al (1997) Tuberculoma of the liver presenting as a hyperechoic mass on ultrasound. Br J Radiol 70:1293–1295CrossRefPubMed
7.
go back to reference Chan HS, Pang J (1989) Isolated giant tuberculomata of the liver detected by computed tomography. Gastrointest Radiol 14:305–307CrossRefPubMed Chan HS, Pang J (1989) Isolated giant tuberculomata of the liver detected by computed tomography. Gastrointest Radiol 14:305–307CrossRefPubMed
8.
go back to reference Kawamori Y, Matsui O, Kitagawa K, Kadoya M et al (1992) Macronodular tuberculoma of the liver: CT and MR findings. AJR Am J Roentgenol 158(2):311–313CrossRefPubMed Kawamori Y, Matsui O, Kitagawa K, Kadoya M et al (1992) Macronodular tuberculoma of the liver: CT and MR findings. AJR Am J Roentgenol 158(2):311–313CrossRefPubMed
10.
go back to reference Levine C (1990) Primary macronodular hepatic tuberculosis: US and CT appearances. Gastrointest Radiol 15:307–309CrossRefPubMed Levine C (1990) Primary macronodular hepatic tuberculosis: US and CT appearances. Gastrointest Radiol 15:307–309CrossRefPubMed
12.
go back to reference Brauner M, Buffard MD et al (1989) Sonography and computed tomography of macroscopic tuberculosis of the liver. J Clin Ultrasound 17:563–568CrossRefPubMed Brauner M, Buffard MD et al (1989) Sonography and computed tomography of macroscopic tuberculosis of the liver. J Clin Ultrasound 17:563–568CrossRefPubMed
13.
go back to reference Epstein BM, Leibowitz CB (1987) Ultrasonographic and computed tomographic appearance of focal tuberculosis of the liver. S Afr Med J 71:461–462PubMed Epstein BM, Leibowitz CB (1987) Ultrasonographic and computed tomographic appearance of focal tuberculosis of the liver. S Afr Med J 71:461–462PubMed
14.
go back to reference Hersch C (1964) Tuberculosis of the liver. A study of 200 cases. S Afr Med J 38:857–863PubMed Hersch C (1964) Tuberculosis of the liver. A study of 200 cases. S Afr Med J 38:857–863PubMed
15.
go back to reference Gallinger S, Strasberg SM, Marcus HI et al (1986) Local hepatic tuberculosis, the cause of a painful hepatic mass: case report and review of literature. Can J Surg 29:451–452PubMed Gallinger S, Strasberg SM, Marcus HI et al (1986) Local hepatic tuberculosis, the cause of a painful hepatic mass: case report and review of literature. Can J Surg 29:451–452PubMed
16.
go back to reference Essop AR, Posen JA, Hodkinson JH et al (1984) Tuberculous hepatitis. A clinical review of 96 cases. Q J Med 53:465–477PubMed Essop AR, Posen JA, Hodkinson JH et al (1984) Tuberculous hepatitis. A clinical review of 96 cases. Q J Med 53:465–477PubMed
17.
18.
go back to reference Jain R, Sawhney S, Gupta RG et al (1998) Sonographic appearances and percutaneous management of primary tuberculous liver abscess. J Clin Ultrasound 27:159–163CrossRef Jain R, Sawhney S, Gupta RG et al (1998) Sonographic appearances and percutaneous management of primary tuberculous liver abscess. J Clin Ultrasound 27:159–163CrossRef
19.
go back to reference Chen HC, Chao YC, Shyu RY et al (2003) Isolated tuberculous liver abscesses with multiple hyperechoic masses on ultrasound: a case report and review of the literature. Liver Int 23:346–350CrossRefPubMed Chen HC, Chao YC, Shyu RY et al (2003) Isolated tuberculous liver abscesses with multiple hyperechoic masses on ultrasound: a case report and review of the literature. Liver Int 23:346–350CrossRefPubMed
20.
go back to reference Harisinghani MG, McLoud TC, Shepherd JA, Ko JP et al (2000) Tuberculosis from head to toe. Radiographics 20:449–470CrossRefPubMed Harisinghani MG, McLoud TC, Shepherd JA, Ko JP et al (2000) Tuberculosis from head to toe. Radiographics 20:449–470CrossRefPubMed
21.
go back to reference Oliva A, Duarte B, Jonasson O et al (1990) The nodular form of local hepatic tuberculosis. A review. J Clin Gastroenterol 12:166–173CrossRefPubMed Oliva A, Duarte B, Jonasson O et al (1990) The nodular form of local hepatic tuberculosis. A review. J Clin Gastroenterol 12:166–173CrossRefPubMed
22.
go back to reference Malde HM, Chadha D (1993) The “cluster” sign in macronodular hepatic tuberculosis: CT features. J Comput Assist Tomogr 17:159–161CrossRefPubMed Malde HM, Chadha D (1993) The “cluster” sign in macronodular hepatic tuberculosis: CT features. J Comput Assist Tomogr 17:159–161CrossRefPubMed
23.
go back to reference Cao BS, Li XL, Li N et al (2010) The nodular form of hepatic tuberculosis: contrast-enhanced ultrasonographic findings with pathologic correlation. J Ultrasound Med 29:881–888PubMed Cao BS, Li XL, Li N et al (2010) The nodular form of hepatic tuberculosis: contrast-enhanced ultrasonographic findings with pathologic correlation. J Ultrasound Med 29:881–888PubMed
24.
go back to reference Stoupis C, Taylor HM, Paley MR et al (1998) The Rocky liver: radiologic-pathologic correlation of calcified hepatic masses. Radiographics 18:675–685CrossRefPubMed Stoupis C, Taylor HM, Paley MR et al (1998) The Rocky liver: radiologic-pathologic correlation of calcified hepatic masses. Radiographics 18:675–685CrossRefPubMed
25.
go back to reference Wilde CC, Kueh YK (1991) Case report: Tuberculous hepatic and splenic abscess. Clin Radiol 43:215–216CrossRefPubMed Wilde CC, Kueh YK (1991) Case report: Tuberculous hepatic and splenic abscess. Clin Radiol 43:215–216CrossRefPubMed
26.
go back to reference Gupta G, Nijhawan S, Katiyar P et al (2011) Primary tubercular liver abscess rupture leading to parietal wall abscess: a rare disease with a rare complication. J Postgrad Med 57:350–352CrossRefPubMed Gupta G, Nijhawan S, Katiyar P et al (2011) Primary tubercular liver abscess rupture leading to parietal wall abscess: a rare disease with a rare complication. J Postgrad Med 57:350–352CrossRefPubMed
27.
go back to reference Venkatesh SK, Tan LK, Siew EP et al (2005) Macronodular hepatic tuberculosis associated with portal vein thrombosis and portal hypertension. Australas Radiol 49:322–324CrossRefPubMed Venkatesh SK, Tan LK, Siew EP et al (2005) Macronodular hepatic tuberculosis associated with portal vein thrombosis and portal hypertension. Australas Radiol 49:322–324CrossRefPubMed
28.
go back to reference Chong VH, Lim KS (2010) Hepatobiliary tuberculosis. Singap Med J 51:744–751 Chong VH, Lim KS (2010) Hepatobiliary tuberculosis. Singap Med J 51:744–751
Metadata
Title
Hepatic tuberculosis: a multimodality imaging review
Authors
Chandan Kakkar
Ashwin M. Polnaya
Prakashini Koteshwara
S. Smiti
K. V. Rajagopal
Ankur Arora
Publication date
01-12-2015
Publisher
Springer Berlin Heidelberg
Published in
Insights into Imaging / Issue 6/2015
Electronic ISSN: 1869-4101
DOI
https://doi.org/10.1007/s13244-015-0440-y

Other articles of this Issue 6/2015

Insights into Imaging 6/2015 Go to the issue